Multiple intersecting pathways are involved in CPEB1 phosphorylation and regulation of translation during mouse oocyte meiosis [0.03%]
多种交叉途径涉及CPEB1在小鼠卵母细胞减数分裂中的磷酸化及对翻译的调节
Chisato Kunitomi,Mayra Romero,Enrico Maria Daldello et al.
Chisato Kunitomi et al.
The RNA-binding protein cytoplasmic polyadenylation element binding 1 (CPEB1) plays a fundamental role in regulating mRNA translation in oocytes. However, the specifics of how and which protein kinase cascades modulate CPEB1 activity are st...
A mathematical framework for measuring and tuning tempo in developmental gene regulatory networks [0.03%]
发育基因调控网络中节奏测量和调整的数学框架
Charlotte L Manser,Ruben Perez-Carrasco
Charlotte L Manser
Embryo development is a dynamic process governed by the regulation of timing and sequences of gene expression, which control the proper growth of the organism. Although many genetic programmes coordinating these sequences are common across ...
Bridget Elaine LaMonica Ostrem,Nuria Domínguez-Iturza,Jeffrey A Stogsdill et al.
Bridget Elaine LaMonica Ostrem et al.
In utero infection and maternal inflammation can adversely impact fetal brain development. Maternal systemic illness, even in the absence of direct fetal brain infection, is associated with an increased risk of neuropsychiatric disorders in...
The people behind the papers - Bridget Ostrem, Nuria Domínguez-Iturza and Paola Arlotta [0.03%]
论文背后的人——布里奇特·奥斯特姆、努里亚·多明格斯-伊图尔萨和保拉·阿尔洛塔
Maternal immune activation can affect the development of embryos, but the underlying mechanisms have been unclear. In a new study, Bridget Ostrem and colleagues show that embryonic microglia detect maternal inflammation, resulting in transc...
Local Ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila [0.03%]
损伤上皮局部合成蜕皮激素以延缓发育并促进果蝇再生
Douglas Terry,Colby Schweibenz,Kenneth Moberg
Douglas Terry
Regenerative ability often declines as animals mature past embryonic and juvenile stages, suggesting that regeneration requires redirection of growth pathways that promote developmental growth. Intriguingly, the Drosophila larval epithelia ...
Rikke Hoegsberg Agerskov,Pia Nyeng
Rikke Hoegsberg Agerskov
Published Erratum
Development (Cambridge, England). 2024 May 15;151(10):dev203018. DOI:10.1242/dev.203018 2024
Endothelial HIF2α suppresses retinal angiogenesis in neonatal mice by upregulating NOTCH signaling [0.03%]
内皮细胞HIF2α通过上调NOTCH信号通路抑制新生小鼠视网膜血管生成
Li-Juan Duan,Yida Jiang,Guo-Hua Fong
Li-Juan Duan
Prolyl hydroxylase domain (PHD) proteins are oxygen sensors that use intracellular oxygen as a substrate to hydroxylate hypoxia-inducible factor (HIF) α proteins, routing them for polyubiquitylation and proteasomal degradation. Typically, ...
Arthur Boutillon,Samhita P Banavar,Otger Campàs
Arthur Boutillon
Living organisms have the ability to self-shape into complex structures appropriate for their function. The genetic and molecular mechanisms that enable cells to do this have been extensively studied in several model and non-model organisms...
The people behind the papers - Jingjing Sun and Angelike Stathopoulos [0.03%]
论文背后的人——孙京京和Angelique Stathopoulos博士
Collective migration of caudal visceral mesoderm (CVM) cells in Drosophila embryos helps form the longitudinal muscles of the larval gut. In their study, Angelike Stathopoulos and colleagues reveal that cell division coordinates two gene ex...
Heterogeneous identity, stiffness and growth characterise the shoot apex of Arabidopsis stem cell mutants [0.03%]
异质性身份，硬度和生长表征了拟南芥干细胞突变体的 shoots apices
Léa Rambaud-Lavigne,Aritra Chatterjee,Simone Bovio et al.
Léa Rambaud-Lavigne et al.
Stem cell homeostasis in the shoot apical meristem involves a core regulatory feedback loop between the signalling peptide CLAVATA3 (CLV3), produced in stem cells, and the transcription factor WUSCHEL, expressed in the underlying organising...