The people behind the papers - Hannah Schrader Dear, Nicole Franks and Benjamin Allen [0.03%]
论文背后的人——汉娜·施拉德、妮可·弗兰克斯和本杰明·艾伦
There has been a lack of experimental tools to visualise endogenous GLI proteins - the transcriptional effectors of the Hedgehog signalling pathway. In a new study, Allen and colleagues present a homozygous reporter mouse line in which each...
Distinct Roles of Atf3, Zfp711, and Bcl6b in Early Embryonic Hematopoietic and Endothelial Lineage Specification [0.03%]
Atf3、Zfp711和Bcl6b在早期胚胎造血和内皮谱系决定中的不同作用
Ridvan Cetin,Giulia Picco,Jente van Staalduinen et al.
Ridvan Cetin et al.
Hematopoiesis occurs in three consecutive overlapping waves in mammals, regulated by transcription factors. We investigated the role of three relatively poorly studied transcription factors in early embryonic hematopoietic development at si...
CD43, but not CD41 or GPI-80, marks first definitive haematopoietic stem cells in the human embryo [0.03%]
CD43而非CD41或GPI-80标记了人类胚胎中第一个明确的造血干细胞
A Ivanovs,S Rybtsov,N Nnadi et al.
A Ivanovs et al.
During mammalian embryonic development, haematopoietic stem cells (HSCs) first emerge in the aorta-gonad-mesonephros (AGM) region. Human definitive HSCs emerge in low numbers and reside within the VE-CAD+CD45+ population consisting of 500-1...
Twinfilin modulates tissue contractility through capping protein uncapping in C. elegans [0.03%]
秀丽隐杆线虫利用twinfilin通过去帽蛋白结合调控组织收缩力
Anupreet Saini,Shir Kreizman,Ekram Towsif et al.
Anupreet Saini et al.
The actin cytoskeleton is dynamically remodelled by conserved regulators to control cell and tissue mechanics. Although many of these proteins are well studied, their roles in driving tissue-specific contractility remains unclear. Twinfilin...
In preprints: cell type-specific gene regulation through the lens of echinoderms [0.03%]
图解海星基因表达的细胞类型特异性调控
Periklis Paganos,Maria Ina Arnone
Periklis Paganos
DILP8 serves as a mature follicle sensor to prevent excessive accumulation of mature follicles in Drosophila ovaries and oocyte aging [0.03%]
DILP8作为卵母细胞成熟的传感器防止果蝇卵巢中成熟卵母细胞的过度积累和卵母细胞衰老
Rebecca Oramas,Katarina Yacuk,Stella E Cho et al.
Rebecca Oramas et al.
Excessive mature follicle accumulation in ovaries harms oocyte health and offspring viability. The mechanism by which females count mature follicles in their ovaries remains a mystery. Recent work demonstrated that Drosophila insulin-like p...
Genomic resources for the scuttle fly Megaselia abdita: A model organism for comparative developmental studies in flies [0.03%]
应用于苍蝇发育比较研究的模式生物Megaselia abdita翅膀芜生蝇基因组资源
Ayse Tenger-Trolander,Ezra Amiri,Valentino Gantz et al.
Ayse Tenger-Trolander et al.
The order Diptera (true flies) holds promise as a model taxon in evolutionary developmental biology due to the inclusion of the model organism, Drosophila melanogaster, and the ability to cost-effectively rear many species in laboratories. ...
SOX2-driven enhancer landscapes define the transcriptional architecture of retinogenesis [0.03%]
SOX2激活的增强子景观定义了视网膜生成的转录组学架构
Fuyun Bian,Kimiasadat Golestaneh,Emily Davis et al.
Fuyun Bian et al.
Retinal neurogenesis is mediated by the coordinated activities of a complex gene regulatory network (GRN) of transcription factors (TFs) in multipotent retinal progenitor cells (RPCs). How this GRN mechanistically guides neural competence r...
José E García-Arrarás,Chunyi Li,Tania Rozario et al.
José E García-Arrarás et al.
The ability of organisms to replace and regenerate anatomical structures following their loss or damage has piqued the curiosity of biologists for centuries. In addition to Development's 'Model systems for regeneration' collection, which in...
Meritxell Huch,Mansi Srivastava,Alex Eve
Meritxell Huch