Dynamic changes in chromatin accessibility during cell fate specification at the neural plate border [0.03%]
神经板边缘细胞命运决定过程中的染色质可及性动态变化
Eva Hamrud,Jacob Leese,Alexandre P Thiery et al.
Eva Hamrud et al.
During development, dynamic changes in gene expression and chromatin architecture drive the transition from progenitors to specialised cell types. Here we use single cell ATAC sequencing (scATAC-seq) to investigate changes in chromatin acce...
Six3/6 acts downstream of canonical Wnt signaling to regulate anterior neural border-derived sensory organ formation in ascidian embryos [0.03%]
六3/6作用于刺Ascidiacea胚细胞的canonical Wnt信号传导下游以调节前神经界衍生的感觉器官形成
Agnès Roure,Rafath Chowdhury,Sébastien Darras
Agnès Roure
Three protruding papillae at the anteriormost region of the ascidian Ciona intestinalis larva constitute an adhesive, mechano- and chemo-sensory organ, the palps, essential for settlement and metamorphosis. The palps derive from the anterio...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems [0.03%]
多功能Gateway诱导克隆多片段拼接(MAGIC)体系：脊椎动物模型系统中使用的灵活组装工具箱
William B Gillespie rd,Yuwen Zhang,Oscar E Ruiz et al.
William B Gillespie rd et al.
Here, we present MultiSite Assembly of Gateway Induced Clones (MAGIC), which leverages Gateway-based recombinatorial cloning technology for rapid, modular assembly of plasmids to facilitate transgenesis in cells and vertebrate animal models...
Nikolas Claussen,Fridtjof Brauns,Sebastian J Streichan
Nikolas Claussen
In morphogenesis, biology uses physics to sculpt organs. Understanding this fascinating process requires interdisciplinary collaboration. We highlight recent work in the 'physics of development', with a focus on the interplay between quanti...
Ben Scheres
Ben Scheres
Despite tremendous progress since the birth of the field in the mid-1980s, plant developmental biologists have not yet deciphered the life cycle of plants at a level that one could expect from the relatively uncomplicated plant body plan. P...
TMO5 regulates PIN1 polarity convergence and organogenesis downstream of MONOPTEROS in the Arabidopsis shoot [0.03%]
拟南芥中MONOPTEROS下游的TMO5调节PIN1极性汇聚及器官发生
Abdul Kareem,Carolyn Ohno,Marcus G Heisler
Abdul Kareem
Plants continuously produce lateral organs, such as leaves and flowers, from the shoot apical meristem (SAM). This process is guided by the accumulation of the plant hormone auxin and the polar localization of the efflux protein PIN-FORMED1...
Pair-rule-like transcription patterns during neural tube closure in a proto-vertebrate [0.03%]
原脊椎动物神经管闭合过程中的成对规则转录模式
Gabrielle Östlund-Sholars,Laurence A Lemaire,Michael S Levine
Gabrielle Östlund-Sholars
Neural tube closure (NTC) is a conserved morphogenetic process in chordates in which the neural plate folds and fuses to form a closed neural tube. While the mechanical forces and signaling pathways governing NTC have been characterized in ...
The mouse neonatal small intestine is regionally specialized for protein absorption and transepithelial transport [0.03%]
小鼠新生儿肠吸收和转运蛋白具有区域特异性
Carina L Block,Laura Childers,Abby L Cortez et al.
Carina L Block et al.
In neonates, gastric protein digestion is limited, requiring specialized mechanisms for intestinal protein absorption. While neonatal enterocytes are thought to mediate endocytosis, degradation, and transcytosis of dietary proteins, whether...
The people behind the papers - Kirsty Uttley, Hannah Jüllig and Hannah Long [0.03%]
论文背后的人——Kirsty Uttley、Hannah Jüllig 和 Hannah Long
Deletions in EC1.45, a non-coding element upstream of SOX2, cause craniofacial developmental differences. In their study, Hannah Long and colleagues study the contribution of this enhancer to facial variation and evolution by investigating ...
Neanderthal-derived variants increase SOX9 enhancer activity in craniofacial progenitors that shape jaw development [0.03%]
尼安德特人遗传变异增强SOX9在塑造颌骨发育的颅面祖细胞中的作用
Kirsty Uttley,Hannah J Jüllig,Carlo De Angelis et al.
Kirsty Uttley et al.
Human facial appearance is a highly variable morphological trait, with both rare and common genetic variants shaping craniofacial morphology between individuals and in disease. Deletions encompassing an enhancer cluster 1.45 megabases upstr...