Lineage-specific enhancer insertions regulate Prdm14 to drive the rapid transition from naïve to formative pluripotency in rodents [0.03%]
谱系特异性增强子插入通过调节PRDM14来驱动啮齿动物从原始态多能性向形成态多能性的快速转换
Kazumi Matsubara,Masaki Hirota,Kentaro Kajiwara et al.
Kazumi Matsubara et al.
The network of transcription factors is dynamically reorganized during the transition from naïve to formative pluripotency. In mice, Prdm14 is expressed in naïve pluripotent cells but rapidly downregulated upon exit from the naïve state....
Metaplastic Barrett's oesophagus represents reversion to a developmental-like epithelial cell state [0.03%]
代谢性巴雷特食管代表向发育-like上皮细胞状态的逆转
Syed Murtuza Baker,Aoibheann Mullan,Rachel E Jennings et al.
Syed Murtuza Baker et al.
In Barrett's oesophagus (BO), the precursor of oesophageal adenocarcinoma, the adult stratified squamous epithelium is replaced by a simple columnar phenotype. This has been considered metaplasia, i.e. the inappropriate conversion from one ...
The people behind the papers - Syed Murtuza Baker and Andy Sharrocks [0.03%]
论文背后的团队——穆尔图扎·巴克尔和安迪·夏罗克斯
Parallels between cancer and developmental states are being increasingly recognised as important. In a new study, Baker et al. use single-nucleus transcriptomic and chromatin profiling to assess cell states and gene regulatory networks in t...
ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket [0.03%]
双氧化酶产生的ROS调节螽斯腿再生过程中细胞增殖和血细胞迁移
Misa Okumura-Hirono,Tetsuya Bando,Yoshimasa Hamada et al.
Misa Okumura-Hirono et al.
Many animals regenerate lost body parts through several signalling pathways; however, the triggers that initiate regeneration remain unclear. In the present study, we focused on the role of reactive oxygen species (ROS) produced by the NADP...
Deletion of an enhancer that controls Wnt gene expression following tissue injury produces increased adipogenesis in regenerated muscle [0.03%]
删除控制组织损伤后Wnt基因表达的增强子会增加再生肌肉中的脂肪生成量
Catriona Y Logan,Xinhong Lim,Matt Fish et al.
Catriona Y Logan et al.
The capacity to detect and respond to injury is critical for the recovery and long-term survival of many organisms. Wnts are commonly induced by tissue damage but how they become activated transcriptionally is not well understood. Here, we ...
In preprints: folding from the top - apical forces drive eye cup formation [0.03%]
来自预印版：从上到下的折叠——顶点力驱动眼杯的形成
Adrián Pérez-Ramos,Paola Bovolenta
Adrián Pérez-Ramos
The people behind the paper - Robert Morabito and Benjamin Martin [0.03%]
论文背后的人-Robert Morabito和Benjamin Martin
Nervous system and mesodermal tissue development in vertebrate embryos rely on the formation of transient midline tissues - such as the floorplate, notochord and hypochord - by midline progenitor cells. In a comprehensive new study, Benjami...
Epidermal cell fusion promotes the transition from an embryonic to a larval transcriptome in C. elegans [0.03%]
C. elegans上皮细胞融合促进胚胎向幼虫转录组的转变
Owen H Funk,Daniel L Levy,David S Fay
Owen H Funk
Cell fusion is a fundamental process in the development of many multicellular organisms, but its precise role in gene regulation and differentiation remains largely unknown. The Caenorhabditis elegans epidermis, which comprises multiple syn...
Modulating the levels and activity of the retinal determination network Is sufficient to induce the specification of distinct tissue fates in Drosophila [0.03%]
调控视黄醛决定网络的水平和活性足以诱导果蝇特定组织的命运决定
Claude B Jean-Guillaume,Bonnie M Weasner,Justin P Kumar
Claude B Jean-Guillaume
A pair of eye-antennal discs give rise to most tissues that comprise the adult head of the fruit fly, Drosophila melanogaster, including a pair of compound eyes and a trio of simple eyes called ocelli. These two visual organs are anatomical...
Myc and Tor drive growth and cell competition in the regeneration blastema of Drosophila wing imaginal discs [0.03%]
Myc和Tor驱动果蝇翅芽盘再生blastema中的生长和细胞竞争
Felicity Ting-Yu Hsu,Rachel Smith-Bolton
Felicity Ting-Yu Hsu
During the regeneration of injured or lost tissues, the regeneration blastema serves as a hub for robust growth. Drosophila imaginal discs are a genetically tractable and simple model system for the study of regeneration and organization of...