Alex Hughes is an Associate Professor of Bioengineering at the University of Pennsylvania, USA, using in vitro organoid models of the developing human kidney to study organogenesis from an engineering perspective. This year, Alex is a Guest...
Mohammad N Taheri,Yuda Xiang,Mo R Ebrahimkhani
Mohammad N Taheri
In embryos, intrinsic and extrinsic signals cooperatively shape cellular decisions to form tissues and organs. Developmental engineering seeks to harness insights into the molecular mechanisms governing embryonic development and leverage pl...
Homologous recombination is essential for DNA damage-induced regeneration of Drosophila testis germline stem cells [0.03%]
同源重组对DNA损伤诱发的果蝇睾丸生殖干细胞再生是必不可少的
Jasmine R Grey,Salman Hasan,Janelle Bellot et al.
Jasmine R Grey et al.
Germline stem cells (GSCs) from mammals to insects preferentially survive ionizing radiation but the underlying mechanisms are not well understood. Here we use the Drosophila testis to study the responses of GSCs to DNA damage in an intact ...
The cloacal outgrowth orchestrates co-development of the bladder and umbilical arteries [0.03%]
泄殖腔突起协调膀胱和脐动脉的共发育
Xing Ye,Liguang Xia,Xianfa Yang et al.
Xing Ye et al.
The urinary bladder is an innovation of eutherian mammals to manage liquid wastes. However, bladder development and its' embryonic function remain poorly understood. Here, we report that in both humans and mice the bladder emerges from the ...
Ecdysone Receptor autonomously controls germ cell differentiation in the Drosophila ovary [0.03%]
节俭素受体在果蝇卵巢中自主控制生殖细胞分化
Lauren E Jung,Alexandria I Warren,Changhong Yin et al.
Lauren E Jung et al.
The steroid hormone ecdysone controls Drosophila ovarian germline stem cell (GSC) maintenance and germ cell differentiation. Prior studies demonstrated that ecdysone regulates germ cell differentiation non-autonomously via the nuclear recep...
Regulation of Hippo signaling by Atrophin in the developing Drosophila wing [0.03%]
Atrophin介导的果蝇翅发育过程中Hippo信号通路的调节机制研究
Deimante Mikalauskaite,Cordelia Rauskolb,Tom Lehan et al.
Deimante Mikalauskaite et al.
Organ development is directed through integration of signaling networks and their transcriptional programs. Investigation of connections between Hippo signaling and the transcriptional co-repressor Atrophin reveals that Atrophin modulates H...
Retinoic acid and FGF signaling interact to control elongation and lineage specification in a mouse gastruloid model [0.03%]
视黄酸和FGF信号相互作用控制小鼠原肠胚模型的延长和谱系分化
Mehmet Yildiz,Noëlle Dommann,Tugce Kardelen Hasdemir et al.
Mehmet Yildiz et al.
Axial elongation and cell fate decisions during early embryonic development are regulated by signaling gradients, such as Retinoic Acid (RA) and Fibroblast Growth Factor (FGF). To assess the role of RA in vitro, studies have relied on its d...
Réda M Zellag,Eric Cheng,Abigail R Gerhold et al.
Réda M Zellag et al.
Animal development is a complex process that requires the coordination of a plethora of pathways in space and time. In several species, the availability of tissue explants has provided a simplified context that facilitates mechanistic inves...
Nuclear Factor Y controls nutrient-adaptive epithelial growth by regulating mTOR in the Drosophila midgut [0.03%]
NF-Y通过在果蝇肠道中调节mTOR来控制营养适应性上皮细胞增殖
Tetiana Strutynska,Onur Deniz,Jaakko Mattila
Tetiana Strutynska
The intestinal epithelial lining is highly dynamic, with size and cellular composition adapting to nutrient status. This requires regulation of intestinal stem cell (ISC) proliferation and enterocyte (EC) size. How the intestinal absorptive...
Primordial germ cells differentially contribute to the germline in zebrafish [0.03%]
斑马鱼原配子体细胞差异性地贡献于生殖系细胞
Maya Pahima,Florence L Marlow
Maya Pahima
Primordial germ cells (PGCs) are the precursors of the germline and among the first cells to be specified during embryogenesis. Contrary to the common assumption that PGCs directly develop into germline stem cells (GSCs), recent data sugges...