Peter K Dearden
Peter K Dearden
Polyphenisms, the production of two or more discrete phenotypes from a single genome, are a remarkable reflection of the flexibility of developmental mechanisms. Examples of polyphenisms include castes in eusocial insects, and winged versus...
In vivo transition in chromatin accessibility during differentiation of deep-layer excitatory neurons in the neocortex [0.03%]
新皮层深层兴奋性神经元分化过程中染色质可及性转变的体内研究
Seishin Sakai,Yurie Maeda,Mai Saeki et al.
Seishin Sakai et al.
During neuronal differentiation, gene transcription patterns change in response to both intrinsic and extrinsic cues. Chromatin regulation at regulatory elements plays a key role in this process. However, how chromatin accessibility evolves...
Single-cell and in situ spatial analyses reveal the diversity of newly born hematopoietic stem cells and of their niches [0.03%]
单细胞和空间转录组分析揭示新生造血干细胞及其生态位的多样性
Léa Torcq,Catherine Vivier,Sandrine Schmutz et al.
Léa Torcq et al.
Hematopoietic stem cells (HSCs) and more committed progenitors (collectively referred to as HSPCs) emerge from vessels during development, via Endothelial-to-Hematopoietic Transition (EHT). Recently, using the zebrafish embryo, we showed th...
Migration of Kupffer's vesicle derived cells is essential for tail morphogenesis in zebrafish embryos [0.03%]
基底外胚层来源的细胞迁移对斑马鱼胚胎尾部形态建成是必不可少的
Jelmer Hoeksma,Jeroen den Hertog
Jelmer Hoeksma
A phenotypic screen of fungal filtrates on developing zebrafish embryos identified metabolites from the fungus Ceratocystis populicola to induce ectopic tail formation, including a split notochord and a duplicated caudal fin. Chemical analy...
The people behind the papers - Jonas Malkmus, Rushikesh Sheth and Rolf Zeller [0.03%]
论文背后的人——琼纳斯·马尔库斯、rushikesh sheth和rolf zeller
Establishing the digit-interdigit patterning in the developing limb bud requires complex signalling inputs. In a new paper in Development, Malkmus et al. use WNT inhibition and a combination of image-based and molecular tools to uncover the...
The people behind the papers - Sarah Soliman and Zara Weinberg [0.03%]
论文背后的人——Sarah Soliman 和Zara Weinberg
Tools built in synthetic biology can recapitulate developmental processes through spatial and temporal control of cellular behaviour, allowing researchers to study the principles of developmental biology. In this new study, Sarah Soliman, Z...
Regulatory feedback between VEGF and ERK pathways controls tip-cell expression during sea urchin skeletogenesis [0.03%]
vegf和erk途径之间的调节反馈控制海胆骨骼发生过程中的尖细胞表达
Tovah Nehrer,Tsvia Gildor,Majed Layous et al.
Tovah Nehrer et al.
The sea urchin skeletogenic gene regulatory network (GRN) shows high similarity to the GRN that controls vertebrate vascularization, suggesting that sea urchin biomineralization evolved through co-option of an ancestral tubulogenesis GRN. D...
Dynamic BMP signaling regulates sclerotome induction and lineage diversification in zebrafish [0.03%]
动态BMP信号转导调节斑马鱼肌腱细胞诱导及谱系分化
Linjun Xie,Roger C Ma,Katrinka M Kocha et al.
Linjun Xie et al.
The sclerotome is an embryonic structure that gives rise to various supportive tissues, including the axial skeleton and connective tissues. Despite its significance, the mechanisms underlying sclerotome induction and diversification during...
Morphogen gradients are regulated by porous media characteristics of the developing tissue [0.03%]
形态发生素梯度受发育组织多孔介质特性调控
Justina Stark,Rohit Krishnan Harish,Ivo F Sbalzarini et al.
Justina Stark et al.
Long-range morphogen gradients have been proposed to form by morphogen diffusion from a localized source to distributed sinks in the target tissue. The role of the complex tissue geometry in this process is, however, less well understood an...
Correction: Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish [0.03%]
订正：刺鼠囊素C通过条纹细胞间信号诱导斑马鱼造血干细胞分化命运决定
Yukino Wada,Hikaru Tsukatani,Chihiro Kuroda et al.
Yukino Wada et al.
Published Erratum
Development (Cambridge, England). 2025 May 15;152(10):dev204947. DOI:10.1242/dev.204947 2025