The people behind the papers - Yuuta Moriyama and Carl-Philipp Heisenberg [0.03%]
Cell访谈：Moriyama和Heisenberg教授
The temporal and spatial expression of Hox genes has been implicated in the establishment of the body plan. In their work, Yuuta Moriyama and colleagues find that spatiotemporally ordered expression of Hoxb genes regulates dynamic cell surf...
Achaete-Scute homolog 1 (ASCL1) is a proneural transcriptional regulator that modulates both cell proliferation and differentiation of neuroblasts (immature nerve cells) during development. In their study, Anna Philpott and colleagues show ...
H3K36me3 Modification by SETD2 is Essential for Col11a2 and Sema3e Transcription to Maintain Dentinogenesis in Mice [0.03%]
组蛋白甲基转移酶SETD2介导的H3K36me3修饰对维持小鼠牙本质形成的Col11a2和Sema3e转录起关键作用
Jiaxin Niu,Jing Fu,Hao Feng et al.
Jiaxin Niu et al.
Dentin is a major mineralized component of teeth generated by odontoblasts. Several types of histone methylation have been reported to play important roles in odontoblast differentiation and dentinogenesis. However, the role of methylation ...
Radhika Padma,Manivannan Subramanian,Anuradha Venkatakrishnan Chimata et al.
Radhika Padma et al.
During development, regulation of gene-expression is key to cellular homeostasis. Gene-expression regulation by non-coding RNAs (ncRNA) involves prevention of mRNAs accumulation or block translation of their target gene. In a forward geneti...
Dong Feng,Yanhan Dong,Yiran Song et al.
Dong Feng et al.
Recent findings have highlighted the complex role of inflammation in zebrafish heart regeneration, demonstrating that while inflammation is essential for initiating transient fibrosis and tissue repair, chronic inflammation, and unresolved ...
Regulatory innovation driven by redundant repressors; Role of klf2 for innovation of the Pmar1-HesC double-negative gate in echinoderms [0.03%]
冗余抑制子驱动的调控创新；Sp转录因子Klf2通过建立Pmar1-HesC二级负反馈回路实现新型转录网络构建及功能分化研究
Nina Levin,Natalia Gogoleva,Atsuko Yamazaki et al.
Nina Levin et al.
The diversity of organism morphology is heavily dependent on the evolution of the Gene regulatory networks (GRNs). However, the mechanistic basis in which change can be incorporated within these systems remains poorly understood. Evolution ...
Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently from mesothelial fate [0.03%]
动态WT1表达在原肠运动过程中独立于浆膜细胞命运决定腹膜平滑肌细胞命运
Suad H Alsukari,Huei Teng Ng,Lilly Lang et al.
Suad H Alsukari et al.
The Wilms' Tumour protein (WT1) was previously linked to the mesothelial and vascular smooth muscle cell (vSMC) lineage in the mouse intestine, with evidence suggesting that intestinal vSMCs arise from the mesothelium. Here, we report that ...
Distinct FGF-FGFR sets regulate inhibitory presynaptic differentiation from parvalbumin- and somatostatin-positive interneurons [0.03%]
不同的FGF-FGFR组调控来自蛋白帕瓦和Somatostatin阳性中间神经元的抑制性前突触分化
Zhengdong Wei,Shasha Zhang,Keke Bai et al.
Zhengdong Wei et al.
Twenty types of GABAergic interneurons form intricate networks to fine-tune neural circuits in the brain. Parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons, the two largest populations of neocortical interneurons, inn...
Embryonic cells differentiate into two distinct lineages - the trophectoderm (TE), which constitutes the outer blastocyst layer and develops into the placenta, and the inner cell mass, which forms the embryo proper - during early mammalian ...
Autism spectrum disorder and congenital heart disease can occur together, but the mechanisms underlying this co-morbidity are unclear. In a new study, Helen Willsey and colleagues study a group of genes that are associated with both autism ...