Michael R Williamson,Sanjana Murali,Benjamin Deneen
Michael R Williamson
Proper development of the central nervous system (CNS) depends on astrocytes, which are the most abundant glial cells in the CNS. Here, we provide an overview of astrocyte ontogeny and morphogenesis, highlighting mechanisms that regulate as...
Differential regulation of eye specification in Drosophila by Polycomb Group (PcG) epigenetic repressors [0.03%]
Polycomb组(PcG)表观遗传抑制因子在果蝇中通过不同方式调节眼发育
Haley E Brown,Claude Jean-Guillaume,Brandon P Weasner et al.
Haley E Brown et al.
During metazoan development, chromatin plasticity and genetic regulation are tightly connected to establish proper tissue fate and patterning. Drosophila imaginal discs are excellent models to study these processes as both genetic and mecha...
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate both excitatory and inhibitory synaptic transmissions in vertebrates. In their work, Yanmei Tao and colleagues show that distinct FGF-FGFR combinations regulate the forma...
Natalie Dye is group leader at the Mechanobiology Institute (MBI), Singapore. She is interested in using the Drosophila wing and human organoid systems to understand how cell dynamics are coordinated in time and space to build complex 3D ti...
Epithelial-mesenchymal interface guides cell shapes and axis elongation in embryonic explants [0.03%]
上皮-间充质界面引导胚胎移植体的细胞形态和轴延长
Katia Barrett,Shalabh Anand,Virginie Thome et al.
Katia Barrett et al.
The spatial arrangement of tissues during development establishes regions of tissue-tissue interactions. While such interactions are prominent during gastrulation and organogenesis, how they guide morphogenesis remains unclear. Here, using ...
Sex-converted testis soma acquires female-specific behaviors and alters XY germline identity [0.03%]
性别转换的睾丸体细胞获得雌性特异性行为并改变XY生殖细胞身份
Tiffany V Roach,Sneh Harsh,Rajiv Sainath et al.
Tiffany V Roach et al.
Establishment and maintenance of cellular sex identity is essential for reproduction. Sex identity of somatic and germline cells must correspond for sperm or oocytes to be produced, with mismatched identity causing infertility in all organi...
Deciphering the role of cis-regulatory elements and TFAP2C in the activation of zygotic Sox2 expression in mouse preimplantation embryos [0.03%]
解读顺式调控元件和TFAP2C在小鼠植入前胚胎合子Sox2表达激活中的作用
Jaehwan Kim,Chad S Driscoll,Lijia Li et al.
Jaehwan Kim et al.
Cell-fate decisions in preimplantation embryos require the coordinated expression of pluripotency and lineage-specific transcription factors. SOX2 represents the first pluripotency regulator whose expression is restricted to the inside cell...
Fbxw7 regulates N1ICD and Sox9 perdurance during pancreas development to ensure proper cell lineage allocation and segregation [0.03%]
Fbxw7通过调节N1ICD和Sox9的持续存在来确保胰腺发育过程中适当的细胞系分配和分离
Diana Wichmann Graff,Emilie Liv Bang-Jensen,Anuska la Rosa Egeskov-Madsen et al.
Diana Wichmann Graff et al.
In the developing pancreas, Notch signaling first maintains multipotent progenitor cells (MPCs), suppressing early endocrine differentiation then promotes their adoption of a duct/endocrine-bipotent progenitor (BP) fate at the expense of No...
Evolution of a novel left-right asymmetry in organ size by co-option of a tissue rotation process [0.03%]
器官大小的新型左右不对称性通过组织旋转过程的征用而进化而来
Bénédicte M Lefèvre,Marine Delvigne,Aurélie Camprodon et al.
Bénédicte M Lefèvre et al.
Left-right asymmetries have repeatedly evolved in diverse animals and affect the position, shape or size of specific organs. How novel left-right asymmetries arise remains unknown. Here, we examined Drosophila pachea, where males have evolv...
Hoxb genes determine the timing of cell ingression by regulating cell surface fluctuations during zebrafish gastrulation [0.03%]
霍索因子基因通过调节斑马鱼原肠运动过程中细胞表面的波动来决定细胞迁入的时间点
Yuuta Moriyama,Toshiyuki Mitsui,Carl-Philipp Heisenberg
Yuuta Moriyama
During embryonic development, cell behaviors need to be tightly regulated in time and space. Yet how the temporal and spatial regulations of cell behaviors are interconnected during embryonic development remains elusive. To address this, we...