Engineering fluorescent reporters in human pluripotent stem cells and strategies for live imaging human neurogenesis [0.03%]
人多能干细胞工程荧光报告基因及活体成像观察人类神经发生的新策略
Alwyn Dady,Lindsay Davidson,Nicolas Loyer et al.
Alwyn Dady et al.
Investigation of cell behaviour and cell biological processes underlying human development is facilitated by creation of fluorescent reporters in human pluripotent stem cells, which can be differentiated into cell types of choice. Here we r...
A PDZ-RapGEF promotes synaptic development in C. elegans through a Rap/Rac signaling pathway [0.03%]
PDZ-RapGEF通过Rap/Rac信号通路促进线虫突触发育
Reagan Lamb,Michael Scales,Julie Watkins et al.
Reagan Lamb et al.
Small G proteins coordinate the development of nerve terminals. The activity of G proteins is finely tuned by GTPase regulatory proteins. Previously, we observed that PXF-1, a Caenorhabditis elegans GTPase regulatory protein, is required fo...
Myocardin-related transcription factor regulates actomyosin contractility and apical junction remodeling during vertebrate neural tube closure [0.03%]
肌钙素相关转录因子调节脊椎动物神经管闭合过程中的肌动蛋白-myosin收缩性和顶侧连接重塑
Keiji Itoh,Olga Ossipova,Sergei Y Sokol
Keiji Itoh
Myocardin-related transcription factor A (Mrtfa), also known as megakaryoblastic leukemia protein (Mkl1/MAL), associates with serum response factor (Srf) to regulate transcription in response to actin dynamics, however, the functions of Mrt...
The people behind the papers - Bénédicte Marie Lefèvre and Michael Lang [0.03%]
论文背后的作者-Bénédicte Marie Lefèvre和Michael Lang
Bilaterians with overall left-right symmetric external bodies often have internal organs that display left-right asymmetry. In a new study, Michael Lang and colleagues study the male genitalia of Drosophila pachea to investigate how left-ri...
Amruta Tendolkar,Mayssa H Mokalled
Amruta Tendolkar
Vertebrates exhibit a range of regenerative capacities following spinal cord injury. At one end of the spectrum are chief regenerators, including teleost fish and urodele amphibians. At the other end, most mammalian species exhibit limited ...
Drosophila imaginal discs serve as great models to study chromatin plasticity and regulation. In their work, Justin Kumar and colleagues reveal that distinct Polycomb Group proteins use different molecular mechanisms to repress eye-to-wing ...
Caenorhabditis elegans LET-381 and DMD-4 control development of the mesodermal HMC endothelial cell [0.03%]
线虫LET-381和DMD-4控制肌细胞瘤细胞的发育
Nikolaos Stefanakis,Jasmine Xi,Jessica Jiang et al.
Nikolaos Stefanakis et al.
Endothelial cells form the inner layer of blood vessels and play key roles in circulatory system development and function. A variety of endothelial cell types have been described through gene expression and transcriptome studies; nonetheles...
Correction: Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel [0.03%]
关于论文“使用光固化水凝胶控制微环境的人多能干细胞空间细胞命运重编程”的更正
Zhe Wang,Akira Numada,Fumi Wagai et al.
Zhe Wang et al.
Published Erratum
Development (Cambridge, England). 2025 Jul 15;152(14):dev205058. DOI:10.1242/dev.205058 2025
A FLOE-related protein regulates the 2-dimensional to 3-dimensional growth transition in the moss Physcomitrium patens [0.03%]
轮藻相关蛋白调节苔藓植物Physcomitrium patens从二维到三维生长的转变
Zoe Weeks,Gargi Chaturvedi,Emily Day et al.
Zoe Weeks et al.
The colonization of the land by plants coincided with the evolution of 3-dimensional (3D) growth; the acquisition of apical cells with the capacity to rotate the plane of cell division. The moss Physcomitrium patens has recently been develo...
Jeffrey Farrell is an Earl Stadtman Investigator at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), USA, where he heads the Unit on Cell Specification and Differentiation. Jeff's group combines s...