Single-cell organogenesis captures complex breast tissue formation in 3D [0.03%]
单细胞器官发生术可捕获三维复杂乳腺组织形成过程
Gat Rauner,Nicole C Traugh,Colin J Trepicchio et al.
Gat Rauner et al.
Current breast organoid models, primarily based on self-assembly, face limitations in accurately mimicking the complex stages of tissue development, notably in replicating detailed tissue architectures and cellular diversity. Here, we demon...
KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration [0.03%]
KLF7通过神经发生和Draxin介导的神经元迁移调控海马发育
Yitong Liu,Wentong Hong,Yuyan Zhou et al.
Yitong Liu et al.
The hippocampus, a brain region that is crucial for cognitive learning, memory and emotional regulation, undergoes its primary development during embryonic and early postnatal stages. Krüppel-like factor 7 (KLF7), a transcription factor as...
Generative model for the first cell fate bifurcation in mammalian development [0.03%]
哺乳动物发育中第一个细胞命运分化的生成模型
Maria Avdeeva,Madeleine Chalifoux,Bradley Joyce et al.
Maria Avdeeva et al.
The first cell fate bifurcation in mammalian development directs cells toward either the trophectoderm (TE) or inner cell mass (ICM) compartments in preimplantation embryos. This decision is regulated by the subcellular localization of a tr...
EMG1 cooperates with GRHL3 in β-catenin-mediated surface ectoderm differentiation to regulate neural tube closure [0.03%]
EMG1与GRHL3在β-连环蛋白介导的表皮分化中协同作用以调节神经管闭合
Chiharu Kimura-Yoshida,Kyoko Mochida,Chihiro Matsuno et al.
Chiharu Kimura-Yoshida et al.
Grainyhead-like transcription factor 3 (GRHL3) directs surface ectoderm differentiation under the control of the canonical Wnt/β-catenin pathway. However, the molecular mechanisms that control nuclear GRHL3 expression through β-catenin ar...
Chee Kiang (Ethan) Ewe is an EMBO Postdoctoral Fellow working in the lab of Oded Rechavi at Tel Aviv University, Israel. Here he studies how small RNAs regulate gene expression and, more specifically, how these enable epigenetic inheritance...
Lionel Christiaen
Lionel Christiaen
Pathway to Independence - an interview with Joaquín Navajas Acedo [0.03%]
走向独立——对Joaquín Navajas Acedo的采访
Joaquín Navajas Acedo is a Postdoc in the lab of Dr Alexander Schier in Biozentrum at the University of Basel, Switzerland. He is interested in how the nervous system evolves and develops at the single-cell level. Joaquín is part of the t...
Anzy Miller, former Sir Henry Wellcome Postdoctoral Fellow supported by Nancy Papalopulu (The University of Manchester, UK), is interested in the mechanisms involved in the generation of human pancreatic endocrine cells. Anzy is part of the...
Giulia Paci is a Postdoctoral Fellow at the Laboratory for Molecular Cell Biology at University College London, UK, supported by Yanlan Mao and Buzz Baum, who is interested in how developmental programmes respond to and buffer mechanical st...
From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms [0.03%]
从基因到模式：解读发育调控机制的五个关键动力学概念
Usha Kadiyala,David Sprinzak,Nicholas A M Monk et al.
Usha Kadiyala et al.
Developmental biology seeks to unravel the intricate regulatory mechanisms orchestrating the transformation of a single cell into a complex, multicellular organism. Dynamical systems theory provides a powerful quantitative, visual and intui...