Application and measurement of tissue-scale tension to avian epithelia in vivo to study multiscale mechanics and inter-germ layer coupling [0.03%]
在体组织尺度张力在多尺度力学和胚层间的耦合中的应用及测量——以禽类上皮为例
Panagiotis Oikonomou,Lisa Calvary,Helena C Cirne et al.
Panagiotis Oikonomou et al.
As cross-disciplinary approaches drawing from mechanics have increasingly influenced our understanding of morphogenesis, tools to measure and perturb physical aspects of embryogenesis have expanded as well. However, it remains a challenge t...
Synovial joint cavitation during limb skeletogenesis entails Na/K-ATPase ion pump expression and osmoregulatory activity [0.03%]
肢骨骼发生过程中滑膜关节腔的形成涉及Na+/K+-ATP酶离子泵的表达及其渗透调节功能
Eiki Koyama,Lutian Yao,Cheri Saunders et al.
Eiki Koyama et al.
Limb synovial joints rely on a water/lubricant-filled cavity to sustain skeletal movement through life, but mechanisms generating the cavity within the primordial joint interzone during embryogenesis remain unclear. Because water accrual wo...
The mex-3 3´ untranslated region is essential for reproduction during temperature stress [0.03%]
_mex-3 3'UTR 在温度压力条件下的繁殖过程中必不可少_
Hannah E Brown,Haik V Varderesian,Oscar Lam et al.
Hannah E Brown et al.
Organisms must sense temperature and modify their physiology to survive environmental stress. Elevated temperature reduces fertility in most sexually reproducing organisms. Maternally supplied mRNAs are required for embryogenesis. They enco...
TOR signalling mediates the collective movement of Border cells in Drosophila oogenesis [0.03%]
Tor信号转导介导果蝇卵生成过程中边界细胞的集体运动现象
Sudipta Halder,Adhisree Sharma,Sayan Acharjee et al.
Sudipta Halder et al.
Collective cell migration is seen in various biological processes spanning embryonic development, organogenesis, wound healing and, unfortunately, cancer metastasis. Here, we have examined the role of the evolutionary conserved Target of Ra...
Christopher Forbes Graham FRS (1940-2025): outstanding developmental biologist and one of a kind [0.03%]
克里斯托弗·福布斯·格雷厄姆爵士(FRS 1940-2025)：杰出的发展生物学家，独一无二的一代宗师
Richard Gardner
Richard Gardner
Chris, as he was known universally, died on 22 May at the age of 84. He was a distinguished embryologist and reproductive physiologist whose kindness and erudition inspired many. He was born in Drumelzier in Scotland on 23 September 1940, a...
The people behind the papers - Danielle Spitzer and Iswar Hariharan [0.03%]
论文背后的科研工作者——Danielle Spitzer和Iswar Hariharan教授
Neighbouring cells have a huge influence on one another in the developing epithelia, but the role of cell-cell adhesion molecules in context-dependent neighbour interactions remains unclear. In a new study, Spitzer and colleagues investigat...
Building and rebuilding complex tissues: strategic visions from a research-led workshop [0.03%]
构建和重建复杂组织：以研究为主导的工作会议的战略愿景
N Sumru Bayin,Benjamin Steventon,Mekayla Storer
N Sumru Bayin
How complex tissues develop and regenerate post-injury is one of the most fascinating and important processes in biology. Recent technical advances that enable the generation of a quantitative understanding of these processes have the poten...
Adhesion strength, cell packing density, and cell surface buckling in pericellular matrix-mediated tissue cohesion [0.03%]
细胞外基质介导的组织凝聚力中的黏附强度、细胞堆积密度和细胞表面起皱现象
Rudolf Winklbauer,Olivia Luu,Debanjan Barua et al.
Rudolf Winklbauer et al.
Pericellular matrix-mediated cell-cell adhesion in Xenopus gastrula tissues is characterized by a spectrum of narrow and wide cell contacts that alternate with the non-adhesive surfaces of the interstitial space. Here we show, first, that k...
A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration [0.03%]
阈值水平的JNK通过JAK/STAT激活损伤反应性增强子以促进组织再生
John W Quinn,Mariah C Lee,Chloe Van Hazel et al.
John W Quinn et al.
Tissue regeneration requires precise activation and coordination of genes, many of which are reused from development. While key factors have been identified, how their expression is initiated and spatially regulated after injury remains unc...
Pyruvate dehydrogenase E1 subunit alpha 2 (PDHA2) is a testis-specific mitochondrial protein involved in energy metabolism and spermatogenesis. In their study, Keisuke Shimada and colleagues show that PDHA2 is crucial for normal spermatogen...