Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM [0.03%]
HAI-2缺陷型小鼠早期发生的丛状肠上皮病变与Matriptase介导的EpCAM裂解无关
Roman Szabo,Makiko Kawaguchi,Hiroaki Kataoka et al.
Roman Szabo et al.
Congenital tufting enteropathy (CTE) is a life-threatening intestinal disorder resulting from loss-of-function mutations in EPCAM and SPINT2. Mice deficient in Spint2, encoding the protease inhibitor HAI-2, develop CTE-like intestinal failu...
The maize preligule band is subdivided into distinct domains with contrasting cellular properties prior to ligule outgrowth [0.03%]
玉米叶片 ligule 形成前 preligule 带分为细胞特性截然不同的几个区域
Wesley R Neher,Carolyn G Rasmussen,Siobhan A Braybrook et al.
Wesley R Neher et al.
The maize ligule is an epidermis-derived structure that arises from the preligule band (PLB) at a boundary between the blade and sheath. A hinge-like auricle also develops immediately distal to the ligule and contributes to blade angle. Her...
Emily Wong is an Associate Professor at the Victor Chang Cardiac Research Institute in Sydney, Australia, where she combines experimental and data science approaches to investigate the role of the non-coding genome in development, disease a...
Wnt7b expressed by hypertrophic chondrocytes is a stimulatory factor for endochondral ossification that is regulated by Smad4 activity [0.03%]
由软骨细胞表达的Wnt7b是通过Smad4活性调节的膜内化骨因子
Sho Tsukamoto,Mai Kuratani,Shinya Tanaka et al.
Sho Tsukamoto et al.
Endochondral ossification contributes to longitudinal skeletal growth. Osteoblasts, which are bone-forming cells, appear close to terminally differentiated hypertrophic chondrocytes during endochondral ossification. We established mice with...
kcnj13 regulates pigment cell shapes in zebrafish and has diverged by cis-regulatory evolution between Danio species [0.03%]
kcnj13通过顺式调控进化调节斑马鱼色素细胞的形态
Marco Podobnik,Ajeet P Singh,Zhenqiang Fu et al.
Marco Podobnik et al.
Teleost fish of the genus Danio are excellent models to study the genetic and cellular bases of pigment pattern variation in vertebrates. The two sister species Danio rerio and Danio aesculapii show divergent patterns of horizontal stripes ...
Correction: The HK5 and HK6 cytokinin receptors mediate diverse developmental pathways in rice [0.03%]
订正：HK5和HK6细胞分裂素受体在水稻中介导多种发育途径
Christian A Burr,Jinjing Sun,Maria V Yamburenko et al.
Christian A Burr et al.
Published Erratum
Development (Cambridge, England). 2023 Aug 1;150(15):dev202221. DOI:10.1242/dev.202221 2023
Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance [0.03%]
系统分析Frazzled受体互作蛋白组鉴定出此前未被报道的轴突导向调节因子
Yixin Zang,Greg J Bashaw
Yixin Zang
The Netrin receptor Dcc and its Drosophila homolog Frazzled play crucial roles in diverse developmental process, including axon guidance. In Drosophila, Fra regulates midline axon guidance through a Netrin-dependent and a Netrin-independent...
Xiaohu Huang,Yulong Fu,Hangnoh Lee et al.
Xiaohu Huang et al.
Drosophila is an important model for studying heart development and disease. Yet, single-cell transcriptomic data of its developing heart have not been performed. Here, we report single-cell profiling of the entire fly heart using ∼3000 Ha...
Conserved chamber-specific polyploidy maintains heart function in Drosophila [0.03%]
果蝇中保守的心室特异性多倍体维持心功能
Archan Chakraborty,Nora G Peterson,Juliet S King et al.
Archan Chakraborty et al.
Developmentally programmed polyploidy (whole-genome duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, in both Drosophila larvae and human organ donors, we reveal distinct ...
Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues [0.03%]
胃肠样衍生的原始生殖细胞样细胞在整合组织中动态发育
Christopher B Cooke,Christopher Barrington,Peter Baillie-Benson et al.
Christopher B Cooke et al.
Primordial germ cells (PGCs) are the early embryonic precursors of gametes - sperm and egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells exposed to signalling cocktails and aggregated into large emb...