Miriam A Genuth,Dörthe Jülich,Andrew T Ton et al.
Miriam A Genuth et al.
Animal tissues exist within a continuum of fluid to solid states, and transitions between states are important for embryonic development, wound healing and cancer metastasis. Fluid to solid transitions are governed by the ratio of adhesive ...
The people behind the papers - Dhaval Gandhi and Jessica Treisman [0.03%]
论文背后的团队——访Dhaval Gandhi和Jessica Treisman女士
Specialised adhesion proteins, such as the Drosophila Sidekick (Sdk), are crucial components of the tricellular adherens junctions (tAJs) that hold three cells together, but how they become localised there remains an open question. In a new...
Hand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects [0.03%]
HAND1基因被HAND2替代后出现功能重叠以及脐膨出和心脏缺陷的独特病症模式
Beth A Firulli,Chloe A Ferguson,Corrie de Gier-de Vries et al.
Beth A Firulli et al.
The bHLH transcription factors HAND1 and HAND2 are expressed in partially overlapping patterns during development. Studies have established evidence for significant functional redundancy between HAND1 and HAND2. To test redundancy fully, we...
Nelfb promotes dermal white adipose tissue formation through RNA Polymerase II mediated adipogenic gene regulation [0.03%]
Nelfb通过RNA聚合酶II介导的促脂肪生成基因调控促进真皮白色脂肪组织形成
Samiksha Mahapatra,Julian Gomez,Uyanga Batzorig et al.
Samiksha Mahapatra et al.
Dermal white adipose tissue (dWAT) is critical for skin homeostasis, contributing to hair follicle regeneration, immune defense, and skin wound healing. dWAT is formed and maintained by the differentiation of adipocyte precursors found in t...
Gas1 regulates embryonic tongue muscle proliferation, differentiation, and maturation via alternative pathways to Hedgehog signaling [0.03%]
Gas1通过与Hh信号不同的途径调节胚胎舌肌的增殖、分化和成熟
Gabrielle C Audu,Sally Y Rohan,Archana Kumari
Gabrielle C Audu
Hedgehog (HH) signaling supports tongue and taste organ development. While tongue is highly muscular, the role of HH signaling in muscle growth remains poorly understood. We recently showed the expression of HH receptor Gas1 in postnatal li...
Automated, high-throughput in-situ hybridization of sea urchin (Lytechinus pictus) embryos [0.03%]
用于海胆（Lytechinus pictus）胚胎的自动化大规模原位杂交技术
Yoon Lee,Chloe Jenniches,Rachel Metry et al.
Yoon Lee et al.
Despite the reach of in situ hybridization (ISH) in developmental biology, it is rarely used at scale. The major bottleneck is the throughput of the assay, which relies upon labor-intensive manual steps. The goal of this study was to develo...
Differentially expressed fusogens specify myocyte states to drive myogenesis [0.03%]
差异表达的融合蛋白指定肌细胞状态以驱动肌细胞生成
Sarah Nahlé,Awais Javed,Loïck Joumier et al.
Sarah Nahlé et al.
During myogenesis, myocyte fusion leads to the formation of multinucleated muscle fibers but how exactly this process is initiated remains poorly understood. Here, we performed single-cell RNA sequencing on mouse somites from E9.5-11.5 embr...
Cytokinins control secondary cell wall formation in the inflorescence stem of Arabidopsis [0.03%]
细胞分裂素通过控制拟南芥花序茎中次生细胞壁的形成来调节植物生长
Vojtech Didi,Dominique Arnaud,Alesia Melnikava et al.
Vojtech Didi et al.
Spatiotemporal control over developmental programs is vital to all organisms. Here, we show that deficiency in cytokinin signaling or biosynthesis leads to early secondary cell wall (SCW) formation in Arabidopsis inflorescence stem that ass...
Enhanced RNA quality control maintains long-term regenerative ability in planarians [0.03%]
增强的RNA质量控制维持了涡虫长期的再生能力
Michael Zelko,Danyan Li,Sudheesh Allikka Parambil et al.
Michael Zelko et al.
Planarians have proficient regenerative abilities that persist undiminished throughout adulthood, mediated by their stem cells (neoblasts). It is unclear how planarians accomplish this, as most animals show age-related declines in health an...
The Drosophila Dpp/BMP signaling directly regulates dpp transcription for optimal ligand dosage [0.03%]
果蝇Dpp/BMP信号直接调节dpp转录以优化配体剂量
Yan Zhang,Ying Feng,Xiaolei Ye et al.
Yan Zhang et al.
Precise control of morphogen dosage in the source is essential for establishing developmental patterning and maintaining signaling stability. Here, we demonstrate that in Drosophila wing imaginal discs, the Dpp/BMP signaling modulates its l...