Epigenetic age and fertility timeline: testing an epigenetic clock to forecast in vitro fertilization success rate [0.03%]
表观遗传时钟在体外受精成功率预测中的应用研究
Davide Marinello,Marco Reschini,Giorgia Di Stefano et al.
Davide Marinello et al.
Background: In the field of in vitro fertilization (IVF), the search for reliable success predictors is ongoing, with novel biomarkers gaining increasing attention. Epigenetic clocks, mathematical models based on DNA meth...
Observational Study
Reproductive biology and endocrinology : RB&E. 2025 Jul 14;23(1):99. DOI:10.1186/s12958-025-01429-5 2025
Polycystic ovary syndrome and excessive body weight impact independently and synergically on fertility treatment outcomes [0.03%]
多囊卵巢综合征和过重独立且协同影响生育治疗结局
Emídio Vale-Fernandes,Mafalda V Moreira,Raquel L Bernardino et al.
Emídio Vale-Fernandes et al.
Background: Polycystic ovary syndrome (PCOS) and obesity can both disrupt reproductive function. However, the extent to which obesity contributes to PCOS manifestations is not very clear. This study aimed to disentangle t...
Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats [0.03%]
出生后的早期雄激素作用决定成年雌性而非雄性大鼠下丘脑中雄激素和雌激素受体的表达
Rocío García-Úbeda,Jose Manuel Fernandez-Garcia,Ulises Primo et al.
Rocío García-Úbeda et al.
Gonadal steroids are involved in the organization and programming of several neural systems. The main objective of this study was to determine whether androgen activity in the early postnatal stage influenced the long-term expression of and...
Energy imbalance in oPOI ovarian granulosa cells is linked to reduced glucose bioavailability and metabolism [0.03%]
能量失衡与卵泡颗粒细胞中葡萄糖可用性和代谢降低有关
Weronika Marynowicz,Paulina Głód,Dawid Maduzia et al.
Weronika Marynowicz et al.
Background: Premature ovarian insufficiency (POI), affecting approximately 1% of women under 40, is associated with impaired fertility. Occult POI (oPOI), an initiating form, is more challenging to detect but still allows...
The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and network meta-analysis [0.03%]
营养补充剂改善女性多囊卵巢综合征有效性的系统评价和网状Meta分析
Guanhua Zhao,Yuxin Fan,Ruixia Li et al.
Guanhua Zhao et al.
Background: Nutritional supplements are known to ameliorate polycystic ovary syndrome (PCOS) and have been shown to modulate endocrine and metabolic markers, oxidative stress markers and inflammatory biomarkers in patient...
Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51-mediated homologous recombination [0.03%]
雷帕霉素通过促进Rad51介导的同源重组减少体外成熟卵母细胞的DNA损伤
Qiyu Yang,Ying Chen,Jiayu Huang et al.
Qiyu Yang et al.
Background: The quality of in vitro matured (IVM) oocytes remains inferior to that of in vivo matured oocytes, likely due to DNA damage induced by the in vitro environment. Although rapamycin has been shown to improve the...
A dual-drug strategy to enhance the function of cryopreserved ovaries by promoting revascularization and inhibiting follicle over-activation [0.03%]
一种通过促进再血管化和抑制卵泡过度激活来增强冷冻卵巢功能的双药策略
Lingyu Li,Jian Yang,Longzhong Jia et al.
Lingyu Li et al.
Background: Ovarian tissue cryopreservation and transplantation (OTCT) is a promising approach for fertility preservation. However, significant follicle loss after transplantation challenges long-term reproductive recover...
Short-term impact of tirzepatide on metabolic hypogonadism and body composition in patients with obesity: a controlled pilot study [0.03%]
tirzepatide对肥胖患者代谢性低性腺功能和体质成分的短期影响：一项控制试点研究
Sandro La Vignera,Rossella Cannarella,Vincenzo Garofalo et al.
Sandro La Vignera et al.
Background: Tirzepatide (TZP), a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has recently been introduced in Italy for the treatment of obesity. Obesity is...
BEZ235-Mediated PI3K/mTOR dual inhibition improves ovarian follicle survival in a preclinical model [0.03%]
PI3K/mTOR双重抑制剂BEZ235改善卵巢卵泡存活的临床前模型研究
Jules Bindels,Laëtitia Bernet,Marlyne Squatrito et al.
Jules Bindels et al.
Background: Follicular loss after ovarian tissue cryopreservation and autotransplantation (OTCTP) remains a major challenge due to follicle activation and ischemia. We evaluated BEZ235, a dual PI3K/mTOR inhibitor, as a st...
A multidisciplinary approach to weight management and reproductive care: a retrospective cohort study on weight loss through personalized and patient-centered care [0.03%]
多学科方法进行体重管理和生殖保健：基于个性化和以患者为中心的护理实现减重的回顾性队列研究
Samantha Schon,Jocelyn Spizman,Daria Stelmak et al.
Samantha Schon et al.
Background: Obesity is a highly prevalent chronic disease with a significant and complex impact on reproduction. National guidelines recommend weight loss prior to pregnancy for patients with obesity to mitigate complicat...