A risk score model based on TGF-β pathway-related genes predicts survival, tumor microenvironment and immunotherapy for liver hepatocellular carcinoma [0.03%]
基于TGF-β通路相关基因的风险评分模型预测肝细胞癌患者的生存情况、肿瘤微环境和免疫治疗反应
Jingsheng Liao,Qi Liu,Jingtang Chen et al.
Jingsheng Liao et al.
Background: Transforming growth factor-beta (TGF-β) signal is an important pathway involved in all stages of liver hepatocellular carcinoma (LIHC) initiation and progression. Therefore, targeting TGF- β pathway may be a...
Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis [0.03%]
利用蛋白质组学分析鉴定LPS诱导的ARDS细胞模型中与Na,K-ATP酶α1结合的不同蛋白
Xu-Peng Wen,Guo Long,Yue-Zhong Zhang et al.
Xu-Peng Wen et al.
Background: Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid, which is related to inflammatory cell infiltration, impaired tight junction of pul...
A novel nanobody as therapeutics target for EGFR-positive colorectal cancer therapy: exploring the effects of the nanobody on SW480 cells using proteomics approach [0.03%]
一种针对EGFR阳性结直肠癌治疗的新型纳米抗体药物：使用蛋白质组学方法探讨纳米抗体对SW480细胞的影响
Thomanai Lamtha,Sucheewin Krobthong,Yodying Yingchutrakul et al.
Thomanai Lamtha et al.
Background: The epidermal growth factor receptor (EGFR) overexpression is found in metastatic colorectal cancer (mCRC). Targeted molecular therapies such as monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKI...
Quantitative proteomic analysis of cerebrospinal fluid reveals CD163, A2M and full-length APP as potential diagnostic biomarkers of paediatric bacterial meningitis [0.03%]
定量分析脑脊液蛋白组发现CD163、A2M和全长APP是儿童细菌性脑膜炎潜在诊断生物标志物
Ting Luo,Sai Yang,Yan Chen et al.
Ting Luo et al.
Background: Bacterial meningitis (BM) is a life-threatening infectious disease of the central nervous system in infants and children. To date, no diagnostic methods for the early and precise diagnosis of paediatric BM hav...
Long noncoding RNA Ftx regulates the protein expression profile in HCT116 human colon cancer cells [0.03%]
长链非编码RNA Ftx调节HCT116人类结肠癌细胞蛋白质表达谱式
Ruzhen Jia,Lulu Song,Zhiqiang Fei et al.
Ruzhen Jia et al.
Background: The long noncoding RNA (lncRNA) five prime to Xist (Ftx) is involved in distant metastasis in colorectal cancer (CRC). This study aimed to investigate Ftx alteration-induced proteomic changes in the highly met...
TMT-based proteomics analysis of the cerebral cortex of TauT knockout rats [0.03%]
基于TMT的TauT基因敲除大鼠脑皮层蛋白质组学分析
Yiming Xia,Xiaoling Huang,Lidong Mo et al.
Yiming Xia et al.
Background: Taurine serves a variety of nutritional and physiological roles, and it is mostly transported in cells via taurine transporter (TauT). The effect of taurine transporter in cerebral cortex is still unknown. We ...
Integrative proteomic characterization of trace FFPE samples in early-stage gastrointestinal cancer [0.03%]
微量石蜡包埋样本的整合型蛋白质组鉴定在早期胃肠道肿瘤中的应用
Lingling Li,Hui Liu,Yan Li et al.
Lingling Li et al.
Background: The surveillance and therapy of early-stage cancer would be better for patients' prognosis. However, the extreme trace amount of tissue samples in different stages have limited in portraying the characterizati...
Predicting protein-protein interactions between banana and Fusarium oxysporum f. sp. cubense race 4 integrating sequence and domain homologous alignment and neural network verification [0.03%]
基于序列和结构同源比对及神经网络鉴别的香蕉与尖孢镰刀菌热带专化型4种族互作蛋白预测
Hui Fang,Cheng Zhong,Chunyan Tang
Hui Fang
Background: The pathogen of banana Fusarium oxysporum f. sp. cubense race 4(Foc4) infects almost all banana species, and it is the most destructive. The molecular mechanism of the interactions between Fusarium oxysporum a...
Identification and validation of serum autoantibodies in children with B-cell acute lymphoblastic leukemia by serological proteome analysis [0.03%]
基于血清蛋白质组分析鉴定并验证B细胞急性淋巴细胞白血病儿童患者血清自身抗体
Runhong Yu,Shiwei Yang,Yufeng Liu et al.
Runhong Yu et al.
Background: B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood. Even though significant progresses have been made in the treatment of B-ALL, some pediatric B-ALL have still poor prognos...
Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer's disease [0.03%]
基于血浆蛋白质的二维凝胶电泳及新型荧光探针技术在老年痴呆病血液标志物研究中的应用分析
Scott B Laffoon,James D Doecke,Anne M Roberts et al.
Scott B Laffoon et al.
Background: The Australian Imaging and Biomarker Lifestyle (AIBL) study of aging is designed to aid the discovery of biomarkers. The current study aimed to discover differentially expressed plasma proteins that could yiel...