To explore the molecular mechanism of IRF7 involved in acute kidney injury in sepsis based on proteomics [0.03%]
基于蛋白质组学探究IRF7在脓毒症急性肾损伤中的分子机制
Li Xiang,Ma Wanli,Song Jiannan et al.
Li Xiang et al.
Background: Acute kidney injury is a common complication of sepsis, and its mechanism is very complicated. The purpose of this study was to investigate the mechanism of key differentially expressed proteins and their rela...
Mass-spectrometry based metabolomics: an overview of workflows, strategies, data analysis and applications [0.03%]
基于质谱的代谢组学概述：工作流程、策略、数据分析及应用
Kosar Hajnajafi,Mohammad Askandar Iqbal
Kosar Hajnajafi
Background: Metabolomics, a burgeoning field within systems biology, focuses on the comprehensive study of small molecules present in biological systems. Mass spectrometry (MS) has emerged as a powerful tool for metabolom...
Plasma proteome analysis of rheumatic patients reveals differences in fingerprints based on cardiovascular history: a pilot study [0.03%]
风湿病患者血浆蛋白质组分析发现基于心血管史的“指纹”差异——一项初步研究
Romy Hansildaar,Max van Velzen,Eduard W J van der Vossen et al.
Romy Hansildaar et al.
The risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is much higher than that in the general population. As its etiology is not fully understood, we performed a pilot study using a shotgun proteomic approach t...
Identification of noval diagnostic biomarker for HFpEF based on proteomics and machine learning [0.03%]
基于蛋白质组学和机器学习的心力衰竭新型诊断生物标志物识别研究
Muyashaer Abudurexiti,Salamaiti Aimaier,Nuerdun Wupuer et al.
Muyashaer Abudurexiti et al.
Background: Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome that currently lacks effective biomarkers for early diagnosis and treatment. This study seeks to identify new potential biomarkers f...
Identification of proteome-wide and functional analysis of lysine crotonylation in multiple organs of the human fetus [0.03%]
人类胎儿多器官蛋白质组范围内的赖氨酸月桂酰化的鉴定及功能分析
Lingyu Huang,Huaizhou Chen,Qiang Yan et al.
Lingyu Huang et al.
Lysine crotonylation (Kcr) is a novel post-translational modification that is important in functional studies. However, our understanding of Kcr in the developing human fetus brain, heart, kidney, liver, and lung remains restricted. In this...
MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF/BDNF-Trkb signaling pathway [0.03%]
microRNA-18a-长链非编码RNA NONRATG-022419靶向PRG-1通过调节NGF/BDNF-TrkB信号通路调控糖尿病引起的认知障碍
Qiong Xiang,Hu Lin,Jia-Sheng Tao et al.
Qiong Xiang et al.
Background: Diabetic encephalopathy (DE) is considered as one of the complications of diabetes,which is associated with cognitive impairment in the pathological process of development. Up to now, phospholipid phosphatase ...
Metabolism-related proteins as biomarkers for predicting prognosis in polycystic ovary syndrome [0.03%]
代谢相关蛋白作为预测多囊卵巢综合征预后的生物标志物
Nan Ding,Ruifang Wang,Peili Wang et al.
Nan Ding et al.
Objective: The study aimed to explore the role of metabolism-related proteins and their correlation with clinical data in predicting the prognosis of polycystic ovary syndrome (PCOS). ...
LC-MS-based quantitation of proteomic changes induced by Norcantharidin in MTB-Treated macrophages [0.03%]
基于LC-MS的定量技术研究雷公藤内酯醇处理巨噬细胞引起的蛋白质组变化
Yi-Lin Wu,Yuan-Ting Li,Gan-Bin Liu et al.
Yi-Lin Wu et al.
Tuberculosis drug resistance contributes to the spread of tuberculosis. Immunotherapy is an effective strategy for treating tuberculosis, with the regulation of macrophage-mediated anti-tuberculosis immunity being crucial. Norcantharidin (N...
Identification of mRNA biomarkers in extremely early hypertensive intracerebral hemorrhage (HICH) [0.03%]
极早期高血压脑出血患者血浆mRNA标志物的筛选与验证
Haidong Gao,Jian Zhang,Xinjun Wang et al.
Haidong Gao et al.
Introduction: Hypertensive intracerebral hemorrhage (HICH) stands out as a critical complication of primary hypertension. Consequently, investigating messenger RNA (mRNA) biomarkers becomes imperative, offering potential ...
Multi-targeted olink proteomics analyses of cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage [0.03%]
多目标寡联蛋白组学分析颅内动脉瘤性蛛网膜下腔出血患者的脑脊液蛋白质表达变化
Rui Ding,Liquan Wu,Shanshan Wei et al.
Rui Ding et al.
Background: The complexity of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) may require the simultaneous analysis of variant types of protein biomarkers to describe it more accurately. In...