Analysis of differential membrane proteins related to matrix stiffness-mediated metformin resistance in hepatocellular carcinoma cells [0.03%]
肝细胞癌细胞中与基质刚度介导的二甲双胍耐药相关的差异膜蛋白分析
Xiangyu Gao,Jiali Qian,Yang Zhang et al.
Xiangyu Gao et al.
Background: Our previous work shows that increased matrix stiffness not only alters malignant characteristics of hepatocellular carcinoma (HCC) cells, but also attenuates metformin efficacy in treating HCC cells. Here, we...
PRM-based quantitative proteomics analysis of altered HSP abundance in villi and decidua of patients with early missed abortion [0.03%]
基于PRM的定量蛋白质组学分析早期难免流产患者绒毛和蜕膜中热休克蛋白丰度变化
Xiao-Fang Chen,Xiao-Qing Chen,Hai-Lian Luo et al.
Xiao-Fang Chen et al.
Objective: In this study, we aimed to identify differentially expressed heat shock protein (HSP) profiles in the villi and decidua from patients with early missed abortion (EMA). ...
Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D [0.03%]
血清蛋白质组鉴定和验证两种新型动脉粥样硬化性主动脉瘤生物标志物：肌动蛋白结合蛋白profilin 1和补体因子D
Yusuke Murakami,Mitsuhiro Nishigori,Hiroaki Yagi et al.
Yusuke Murakami et al.
Background: Effective diagnostic biomarkers for aortic aneurysm (AA) that are detectable in blood tests are required because early detection and rupture risk assessment of AA can provide insights into medical therapy and ...
Altered levels of transthyretin in human cerebral microdialysate after subarachnoid haemorrhage using proteomics; a descriptive pilot study [0.03%]
蛋白质组学在蛛网膜下腔出血后人脑微透析液中转运蛋白水平变化的描述性初步研究
Fredrik Ginstman,Bijar Ghafouri,Peter Zsigmond
Fredrik Ginstman
Background: Subarachnoid haemorrhage (SAH) is one of the most severe forms of stroke in which delayed cerebral ischemia is one of the major complications. Neurointensive care aims at preventing and treating such complicat...
Data-independent acquisition-based mass spectrometry(DIA-MS) for quantitative analysis of patients with chronic hepatitis B [0.03%]
数据独立采集质谱法(DIA-MS)用于慢性乙型肝炎患者定量分析
Bo Wang,Qian Zhang,Lili Wu et al.
Bo Wang et al.
Chronic hepatitis B is a significant public health problem and complex pathologic process, and unraveling the underlying mechanisms and pathophysiology is of great significance. Data independent acquisition mass spectrometry (DIA-MS) is a l...
Purification and proteomic analysis of potent fibrinolytic enzymes extracted from Lumbricus rubellus [0.03%]
表强壮纤溶酶活性的环节蠕虫蛋白的纯化及质谱鉴定
Laurentia Stephani,Puji Rahayu,Debbie Retnoningrum et al.
Laurentia Stephani et al.
Background: Lumbrokinase derived from earthworms, Lumbricus rubellus is known to have fibrinolytic enzymes that have potential as therapeutic drugs due to its ability to dissolve fibrin. The current study is aimed to puri...
Proteomics identifies differentially expressed proteins in glioblastoma U87 cells treated with hederagenin [0.03%]
基于蛋白质组学的毛蕊异黄素诱导U87胶质瘤细胞分化的作用机制研究
Yesen Zhang,Yi Han,Yuchun Shang et al.
Yesen Zhang et al.
Objective: We investigated differentially expressed proteins (DEPs) in human glioblastoma U87 cells after treatment with hederagenin as a therapeutic screening mechanism and provided a theoretical basis for hederagenin in...
Proteomics profiling for the global and acetylated proteins of papillary thyroid cancers [0.03%]
乳头状甲状腺癌的整体及乙酰化蛋白质组学研究
Wei Wei,Yuezhang Wu,Dong-Dong Chen et al.
Wei Wei et al.
Background: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy cancer among the malignancies of thyroid. Despite of wide usages of proteomics in PTC, the profile of acetylated proteins in PTC remain...
Effects of Atractylodes lancea extracts on intestinal flora and serum metabolites in mice with intestinal dysbacteriosis [0.03%]
白鲜皮提取物对肠菌失调小鼠肠道微生物和血清代谢物的影响
BaiNian Zhang,Lan Bu,Hui Tian et al.
BaiNian Zhang et al.
Objective: This study aims to explore the effect of an extract of Atractylodes lancea (A. lancea) on antibiotics-induced intestinal tract disorder and the probable therapeutic mechanisms employed by this extract to amelio...
Proteomics analysis of methionine enkephalin upregulated macrophages against infection by the influenza-A virus [0.03%]
甲硫氨酸脑啡肽诱导巨噬细胞抗流感病毒蛋白组学研究
Wenrui Fu,Zifeng Xie,Mei Bai et al.
Wenrui Fu et al.
Macrophages have a vital role in phagocytosis and antiviral effect against invading influenza viruses. Previously, we found that methionine enkephalin (MENK) inhibited influenza virus infection by upregulating the "antiviral state" of macro...