Upregulation of S100A8 in peripheral blood mononuclear cells from patients with depression treated with SSRIs: a pilot study [0.03%]
一项初步研究：五羟色胺再摄取抑制剂治疗抑郁症患者外周血单个核细胞中S100A8的上调
Concepción Gamboa-Sánchez,Enrique Becerril-Villanueva,Samantha Alvarez-Herrera et al.
Concepción Gamboa-Sánchez et al.
Background: Major depressive disorder (MDD) affects more than 350 million people worldwide, and there is currently no laboratory test to diagnose it. This pilot study aimed to identify potential biomarkers in peripheral b...
Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus [0.03%]
人胎儿肺假腺泡期和 canalicular 期系统性赖氨酸巴豆酰化蛋白质组分析
Wei Wang,Wei Shi,Yinglan Wang et al.
Wei Wang et al.
Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We c...
TMT quantitative proteomics reveals key proteins relevant to microRNA-1-mediated regulation in osteoarthritis [0.03%]
TMT定量蛋白组学揭示microRNA-1在骨关节炎中的作用机制
Pinpin Jiang,Dan Liang,Hang Wang et al.
Pinpin Jiang et al.
Osteoarthritis (OA) is the second-commonest arthritis, but pathogenic and regulatory mechanisms underlying OA remain incompletely understood. Here, we aimed to identify the mechanisms associated with microRNA-1 (miR-1) treatment of OA in ro...
Quantitative proteomics analysis reveals the key proteins related to semen quality in Niangya yaks [0.03%]
定量蛋白组学分析揭示尼雅雅牛精液品质相关关键蛋白质
Yaomei Wang,Yuchao Liu,Tingting Cao et al.
Yaomei Wang et al.
Background: Proteins related to sperm motility and sperm morphology have an important impact on sperm function such as metabolism, motility and fertilisation etc. An understanding of the key proteins related to semen qual...
Label-free quantitative proteomic analysis of serum exosomes in mice with thoracic aortic aneurysm [0.03%]
无标签定量蛋白质组学分析胸主动脉瘤小鼠血清外泌体蛋白质组成变化
Jia Xu,Jiacheng Liu,Yibai Qu et al.
Jia Xu et al.
Objective: Thoracic aortic aneurysm (TAA) is a cardiovascular disease with high morbidity and mortality. However, the causes and mechanisms of TAA are not fully understood. Serum exosomes from mice with TAA were used to e...
Integrated proteome and malonylome analyses reveal the potential meaning of TLN1 and ACTB in end-stage renal disease [0.03%]
整合蛋白质组和丙二酰化组分析揭示TLN1和ACTB在终末期肾病中的潜在意义
Ruqi Tan,Dandan Li,Nan Hu et al.
Ruqi Tan et al.
Background: End-stage renal disease (ESRD) is a condition that is characterized by the loss of kidney function. ESRD patients suffer from various endothelial dysfunctions, inflammation, and immune system defects. Lysine m...
Effects of µ-Conotoxin GIIIB on the cellular activity of mouse skeletal musculoblast: combined transcriptome and proteome analysis [0.03%]
µ-石房蛤毒素GIIIB对小鼠骨骼肌细胞活性的影响：转录组和蛋白质组联合分析
Han-Xi Wu,Pei-Min He,Rui Jia
Han-Xi Wu
µ-Conotoxin GIIIB (µ-CTX GIIIB) is a polypeptide containing three disulfide bridges, produced by the sea snail Conus geographus. This study was aimed to explored the cytotoxic effects of µ-CTX GIIIB on mouse skeletal musculoblast (Sol8)....
Proteomic analysis of neonatal mouse hearts shows PKA functions as a cardiomyocyte replication regulator [0.03%]
蛋白组分析新生小鼠心脏显示PKA作为心肌细胞复制调节因子的功能
Lizhi Hu,Minglu Liang,Qin Jiang et al.
Lizhi Hu et al.
The ability of the adult mammalian heart to regenerate can save the cardiac muscle from a loss of function caused by injury. Cardiomyocyte regeneration is a key aspect of research for the treatment of cardiovascular diseases. The mouse hear...
Proteomic analysis of ceftazidime and meropenem-exposed Pseudomonas aeruginosa ATCC 9027 [0.03%]
暴露于头孢他啶和美罗培南的恶臭假单胞菌ATCC 9027的蛋白质组学分析
Hong Loan Ngo,Thuc Quyen Huynh,Nguyen Bao Vy Tran et al.
Hong Loan Ngo et al.
Background: Pseudomonas aeruginosa is well known for its intrinsic ability to resist a wide range of antibiotics, thus complicates treatment. Thus, understanding the response of the pathogen to antibiotics is important fo...
Insight into the underlying molecular mechanism of dilated cardiomyopathy through integrative analysis of data mining, iTRAQ-PRM proteomics and bioinformatics [0.03%]
通过数据挖掘、iTRAQ-PRM蛋白质组学和生物信息学的综合分析探讨扩张型心肌病潜在分子机制
Hongli Xiong,Zhe Zheng,Congcong Zhao et al.
Hongli Xiong et al.
Background: DCM is a common cardiomyopathy worldwide, which is characterized by ventricular dilatation and systolic dysfunction. DCM is one of the most widespread diseases contributing to sudden death and heart failure. H...