Integrated oral microgel system ameliorates renal fibrosis by hitchhiking co-delivery and targeted gut flora modulation [0.03%]
口腔微凝胶系统通过协同递送和靶向肠道菌群调节来改善肾纤维化
Yu Hou,Lin Zhu,Xiaofeng Ye et al.
Yu Hou et al.
Background: Renal fibrosis is a progressive process associated with chronic kidney disease (CKD), contributing to impaired kidney function. Active constituents in traditional Chinese herbs, such as emodin (EMO) and asiati...
Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses [0.03%]
针对致病性人冠状病毒（包括SARS-CoV-2）的治疗型纳米抗体
Yang Yang,Fang Li,Lanying Du
Yang Yang
Nanobodies, single-domain antibodies derived from variable domain of camelid or shark heavy-chain antibodies, have unique properties with small size, strong binding affinity, easy construction in versatile formats, high neutralizing activit...
Retraction Note: Copper-based metal-organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade [0.03%]
撤回 notice: 基于铜的金属有机框架通过局部剥夺雌激素和阻断血小板来阻止三阴性乳腺癌转移
Sijie Wang,Na Yin,Yongjuan Li et al.
Sijie Wang et al.
Retraction of Publication
Journal of nanobiotechnology. 2024 May 31;22(1):302. DOI:10.1186/s12951-024-02589-z 2024
M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2/NF-κB signaling axis [0.03%]
M1型巨噬细胞源性外泌体通过LCN2/NF-κB信号轴增强纤维环细胞衰老促进椎间盘退变
Chunyang Fan,Wei Wang,Zilin Yu et al.
Chunyang Fan et al.
Intervertebral disc degeneration (IVDD) is the primary factor contributing to low back pain (LBP). Unlike elderly patients, many young IVDD patients usually have a history of trauma or long-term abnormal stress, which may lead to local infl...
A quick and innovative pipeline for producing chondrocyte-homing peptide-modified extracellular vesicles by three-dimensional dynamic culture of hADSCs spheroids to modulate the fate of remaining ear chondrocytes in the M1 macrophage-infiltrated microenvironment [0.03%]
一种快速创新的制备软骨归巢肽修饰外泌体的流程：通过三维动态培养人耳脂肪干细胞球体，以调节M1巨噬细胞浸润微环境中残留软骨细胞的命运
Jianguo Chen,Enchong Zhang,Yingying Wan et al.
Jianguo Chen et al.
Background: Extracellular vesicles (EVs) derived from human adipose-derived mesenchymal stem cells (hADSCs) have shown great therapeutic potential in plastic and reconstructive surgery. However, the limited production and...
Glutathione-depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy [0.03%]
用于增强青黛素治疗急性髓系白血病的疗效的谷胱甘肽耗竭脂质体佐剂
Yi Liu,Xiaoning Wang,Hui Feng et al.
Yi Liu et al.
Background: Discrepancies in the utilization of reactive oxygen species (ROS) between cancer cells and their normal counterparts constitute a pivotal juncture for the precise treatment of cancer, delineating a noteworthy ...
Laser-activable murine ferritin nanocage for chemo-photothermal therapy of colorectal cancer [0.03%]
激光激活的小鼠铁蛋白纳米笼用于结直肠癌化疗和光热治疗
Jinmei Cheng,Jiaxin Li,Qilin Yu et al.
Jinmei Cheng et al.
Chemotherapy, as a conventional strategy for tumor therapy, often leads to unsatisfied therapeutic effect due to the multi-drug resistance and the serious side effects. Herein, we genetically engineered a thermal-responsive murine Ferritin ...
Exosome-derived circUPF2 enhances resistance to targeted therapy by redeploying ferroptosis sensitivity in hepatocellular carcinoma [0.03%]
肝细胞癌来源的外泌体环状circUPF2通过重新部署铁死亡敏感性增强对靶向治疗的耐药性
Feng-Lin Dong,Zong-Zhen Xu,Ying-Qiao Wang et al.
Feng-Lin Dong et al.
Background: Advanced hepatocellular carcinoma (HCC) can be treated with sorafenib, which is the primary choice for targeted therapy. Nevertheless, the effectiveness of sorafenib is greatly restricted due to resistance. Re...
A combination of a TLR7/8 agonist and an epigenetic inhibitor suppresses triple-negative breast cancer through triggering anti-tumor immune [0.03%]
TLR7/8激动剂和表观遗传抑制剂联用通过激活抗肿瘤免疫而抑制三阴性乳腺癌的作用及机制研究
Zhenzhen Jiang,Guangqing Cai,Haiting Liu et al.
Zhenzhen Jiang et al.
Background: Combination therapy involving immune checkpoint blockade (ICB) and other drugs is a potential strategy for converting immune-cold tumors into immune-hot tumors to benefit from immunotherapy. To achieve drug sy...
Efficient signal sequence of mRNA vaccines enhances the antigen expression to expand the immune protection against viral infection [0.03%]
高效的信使rna疫苗信号序列增强抗原表达以扩大对病毒感染的免疫防护能力
Yupei Zhang,Songhui Zhai,Hai Huang et al.
Yupei Zhang et al.
The signal sequence played a crucial role in the efficacy of mRNA vaccines against virus pandemic by influencing antigen translation. However, limited research had been conducted to compare and analyze the specific mechanisms involved. In t...