Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment [0.03%]
外泌体靶向乙肝病毒-宿主相互作用重塑肝脏免疫微环境
Xiaojing Wu,Junqi Niu,Ying Shi
Xiaojing Wu
Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due to its hepatotropism, the hepatitis B virus (HBV) cannot infect other cells. The mechanisms underlying...
NK-92 cells labeled with Fe3O4-PEG-CD56/Avastin@Ce6 nanoprobes for the targeted treatment and noninvasive therapeutic evaluation of breast cancer [0.03%]
Fe3O4-PEG-CD56/阿瓦斯汀@Ce6纳米探针标记的NK-92细胞在乳腺癌靶向治疗及非侵入性疗效评估中的应用
Jingge Lian,Meng Li,Meng Duan et al.
Jingge Lian et al.
Adoptive cellular immunotherapy as a promising and alternative cancer therapy platform is critical for future clinical applications. Natural killer (NK) cells have attracted attention as an important type of innate immune regulatory cells t...
Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy [0.03%]
骨靶向钙镁纳米递药平台调控炎性微环境促进骨形成治疗骨质疏松症
Zhenzhen Weng,Jing Ye,Changxiong Cai et al.
Zhenzhen Weng et al.
Osteoporosis is the most common bone metabolic disease that affects the health of middle-aged and elderly people, which is hallmarked by imbalanced bone remodeling and a deteriorating immune microenvironment. Magnesium and calcium are pivot...
Differential reinforcement of cGAS-STING pathway-involved immunotherapy by biomineralized bacterial outer membrane-sensitized EBRT and RNT [0.03%]
由生物矿化细菌外膜敏化的EBRT和RNT差异化增强cGAS-STING通路相关免疫疗法
Mengling Shen,Li Guo,Hengyu Zhang et al.
Mengling Shen et al.
Radiotherapy (RT), including external beam radiation therapy (EBRT) and radionuclide therapy (RNT), realizes physical killing of local tumors and activates systemic anti-tumor immunity. However, these effects need to be further strengthened...
Dual-mode nanoprobe strategy integrating ultrasound and near-infrared light for targeted and synergistic arterial thrombolysis [0.03%]
一种双模式纳米探针策略，集成超声和近红外光用于靶向协同溶栓治疗动脉血栓
Zhiwen Wang,Nan Jiang,Zhixin Jiang et al.
Zhiwen Wang et al.
Efficient thrombolysis in time is crucial for prognostic improvement of patients with acute arterial thromboembolic disease, while limitations and complications still exist in conventional thrombolytic treatment methods. Herein, our study s...
Recent progress of iron-based nanomaterials in gene delivery and tumor gene therapy [0.03%]
铁基纳米材料在基因递送和肿瘤基因治疗领域最新研究进展
Ya Gong,Xiaoyan Hu,Ming Chen et al.
Ya Gong et al.
Gene therapy aims to modify or manipulate gene expression and change the biological characteristics of living cells to achieve the purpose of treating diseases. The safe, efficient, and stable expression of exogenous genes in cells is cruci...
Development of 225Ac-doped biocompatible nanoparticles for targeted alpha therapy [0.03%]
用于靶向α治疗的掺杂225Ac的生物相容性纳米颗粒的发展
Miguel Toro-González,Ngozi Akingbesote,Amber Bible et al.
Miguel Toro-González et al.
Targeted alpha therapy (TAT) relies on chemical affinity or active targeting using radioimmunoconjugates as strategies to deliver α-emitting radionuclides to cancerous tissue. These strategies can be affected by transmetalation of the pare...
Adjuvants for cancer mRNA vaccines in the era of nanotechnology: strategies, applications, and future directions [0.03%]
纳米技术时代的癌症mRNA疫苗佐剂：策略、应用和未来方向
Lei-Ming Cao,Yi-Fu Yu,Zi-Zhan Li et al.
Lei-Ming Cao et al.
Research into mRNA vaccines is advancing rapidly, with proven efficacy against coronavirus disease 2019 and promising therapeutic potential against a variety of solid tumors. Adjuvants, critical components of mRNA vaccines, significantly en...
Improving dermal fibroblast-to-epidermis communications and aging wound repair through extracellular vesicle-mediated delivery of Gstm2 mRNA [0.03%]
通过细胞外囊泡介导的Gstm2 mRNA递送改善真皮成纤维细胞到表皮的通信及衰老伤口修复
Haiyan Wu,Zuochao Yao,Hongkun Li et al.
Haiyan Wu et al.
Skin aging is characterized by the disruption of skin homeostasis and impaired skin injury repair. Treatment of aging skin has long been limited by the unclear intervention targets and delivery techniques. Engineering extracellular vesicles...
Oral administration of probiotic spore ghosts for efficient attenuation of radiation-induced intestinal injury [0.03%]
口服给予芽孢益生菌高效缓解放射性肠损伤的作用及机制研究
Cuixia Zheng,Mengya Niu,Yueyue Kong et al.
Cuixia Zheng et al.
Radiation-induced intestinal injury is the most common side effect during radiotherapy of abdominal or pelvic solid tumors, significantly impacting patients' quality of life and even resulting in poor prognosis. Until now, oral application ...