Ultrasound targeted microbubble destruction assisted exosomal delivery of siHmox1 effectively inhibits doxorubicin-induced cardiomyocyte ferroptosis [0.03%]
超声微泡辅助溶酶体递送siHmox1有效抑制多柔比星致心肌细胞铁死亡
Jianmei Chen,Shuo Qiu,Yang Liu et al.
Jianmei Chen et al.
Ferroptosis, triggered by iron overload and excessive lipid peroxidation, plays a pivotal role in the progression of DOX-induced cardiomyopathy (DIC), and thus limits the use of doxorubicin (DOX) in clinic. Here, we further showed that card...
Temporal and spatial resolution of magnetosome degradation at the subcellular level in a 3D lung carcinoma model [0.03%]
三维肺癌模型中亚细胞水平磁小体降解的时间和空间分辨率
Alicia G Gubieda,Lucía Gandarias,Mihály Pósfai et al.
Alicia G Gubieda et al.
Magnetic nanoparticles offer many exciting possibilities in biomedicine, from cell imaging to cancer treatment. One of the currently researched nanoparticles are magnetosomes, magnetite nanoparticles of high chemical purity synthesized by m...
Multi-omics analysis of Au@Pt nanozyme for the modulation of glucose and lipid metabolism [0.03%]
基于Au@Pt纳米酶的糖脂代谢调控多组学研究
Yanan Wang,Qi Zhang,Minrui Kan et al.
Yanan Wang et al.
Au@Pt nanozyme, a bimetallic core-shell structure Au and Pt nanoparticle, has attracted significant attention due to its excellent catalytic activity and stability. Here, we propose that Au@Pt improves glucose tolerance and reduces TG after...
Macrophage-derived extracellular vesicles represent a promising endogenous iron-chelating therapy for iron overload and cardiac injury in myocardial infarction [0.03%]
巨噬细胞源外泌体代表了一种有前景的内源性铁螯合疗法，可治疗心肌梗死中铁过载和心脏损伤
Dong Guo,Xue Yang,Rui Yu et al.
Dong Guo et al.
Background: Cardiac iron overload and ferroptosis greatly contribute to the poor prognosis of myocardial infarction (MI). Iron chelator is one of the most promising strategies for scavenging excessive iron and alleviating...
Solid-state electron-mediated z-scheme heterostructured semiconductor nanomaterials induce dual programmed cell death for melanoma therapy [0.03%]
固态电子介导的z型半导体纳米材料诱导黑色素瘤治疗中的双重程序性细胞死亡
Yiping Ren,Yun Wang,Cheng Chen et al.
Yiping Ren et al.
The programmed cell death (PCD) pathway removes functionally insignificant, infection-prone, or potentially tumorigenic cells, underscoring its important role in maintaining the stability of the internal environment and warding off cancer a...
Nanomaterial-integrated injectable hydrogels for craniofacial bone reconstruction [0.03%]
用于颅面骨重建的纳米材料整合注射式水凝胶
Yong Xia,Zihan Chen,Zebin Zheng et al.
Yong Xia et al.
The complex anatomy and biology of craniofacial bones pose difficulties in their effective and precise reconstruction. Injectable hydrogels (IHs) with water-swollen networks are emerging as a shape-adaptive alternative for noninvasively reb...
Insights into the prospects of nanobiomaterials in the treatment of cardiac arrhythmia [0.03%]
纳米生物材料在治疗心脏心律失常中的前景展望
Dingkun Lu,Xiaohan Fan
Dingkun Lu
Cardiac arrhythmia, a disorder of abnormal electrical activity of the heart that disturbs the rhythm of the heart, thereby affecting its normal function, is one of the leading causes of death from heart disease worldwide and causes millions...
Titanium nanoparticles released from orthopedic implants induce muscle fibrosis via activation of SNAI2 [0.03%]
钛纳米颗粒通过激活SNAI2诱导肌肉纤维化
Gengming Zhang,Linhua Deng,Zhongjing Jiang et al.
Gengming Zhang et al.
Titanium alloys represent the prevailing material employed in orthopedic implants, which are present in millions of patients worldwide. The prolonged presence of these implants in the human body has raised concerns about possible health eff...
DNA hydrogels and their derivatives in biomedical engineering applications [0.03%]
用于生物医学工程应用的DNA水凝胶及其衍生物
Rui Wu,Wenting Li,Pu Yang et al.
Rui Wu et al.
Deoxyribonucleotide (DNA) is uniquely programmable and biocompatible, and exhibits unique appeal as a biomaterial as it can be precisely designed and programmed to construct arbitrary shapes. DNA hydrogels are polymer networks comprising cr...
GAPDH-Silence Microsphere via Reprogramming Macrophage Metabolism and eradicating Bacteria for Diabetic infection bone regeneration [0.03%]
基于重编程巨噬细胞代谢和杀菌的GAPDH-Silence微球促进糖尿病感染骨再生
Jiale Jin,Xiaowei Xia,Chengxin Ruan et al.
Jiale Jin et al.
Macrophage metabolism dysregulation, which is exacerbated by persistent stimulation in infectious and inflammatory diseases, such as diabetic infectious bone defects (DIBD), eventually leads to the failure of bone repair. Here, we have deve...