Tumor-specific enhanced NIR-II photoacoustic imaging via photothermal and low-pH coactivated AuNR@PNIPAM-VAA nanogel [0.03%]
一种通过光热和低pH协同激活的金纳米棒@聚N-异丙基丙烯酰胺-vaa纳米凝胶用于肿瘤特异性近红外二区成像
Xiaodong Sun,Yujie Li,Xiaowan Liu et al.
Xiaodong Sun et al.
Background: Properly designed second near-infrared (NIR-II) nanoplatform that is responsive tumor microenvironment can intelligently distinguish between normal and cancerous tissues to achieve better targeting efficiency....
Dual depletion of myeloid-derived suppressor cells and tumor cells with self-assembled gemcitabine-celecoxib nano-twin drug for cancer chemoimmunotherapy [0.03%]
自组装吉西他滨/塞来昔布纳米双药协同诱导髓系源抑制细胞和肿瘤细胞双重凋亡用于癌症化疗免疫治疗研究
Xiaojie Zhang,Qiangwei Liang,Yongjin Cao et al.
Xiaojie Zhang et al.
Myeloid-derived suppressor cells (MDSCs) have played a significant role in facilitating tumor immune escape and inducing an immunosuppressive tumor microenvironment. Eliminating MDSCs and tumor cells remains a major challenge in cancer immu...
Accelerated full-thickness skin wound tissue regeneration by self-crosslinked chitosan hydrogel films reinforced by oxidized CNC-AgNPs stabilized Pickering emulsion for quercetin delivery [0.03%]
氧化CNC-AgNPs稳定Pickering乳液增强的自交联壳聚糖水凝胶薄膜促进富集槲皮素加速全层皮肤伤口组织再生
Garima Sharma,Jomon George Joy,Ashish Ranjan Sharma et al.
Garima Sharma et al.
Background: The non-toxic self-crosslinked hydrogel films designed from biocompatible materials allow for controlled drug release and have gathered remarkable attention from healthcare professionals as wound dressing mate...
Strategic disruption of cancer's powerhouse: precise nanomedicine targeting of mitochondrial metabolism [0.03%]
战略性干扰癌症的能量工厂：精准的纳米医学靶向线粒体代谢
Pei Lin,Ye Lu,Jiarong Zheng et al.
Pei Lin et al.
Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as the hub of oxidative metabolism where sugars, fats, and amino acids are ultimately oxidized to release energy. This crucial function fuels a variety ...
Boosting the sonodynamic performance of CoBiMn-layered double hydroxide nanoparticles via tumor microenvironment regulation for ultrasound imaging-guided sonodynamic therapy [0.03%]
通过调节肿瘤微环境增强钴 Birnessite 锰水滑石纳米粒子的声动力学性能用于超声成像引导的声动力治疗
Shuqing Yang,Tingting Hu,Gareth R Williams et al.
Shuqing Yang et al.
Sonodynamic therapy (SDT), a promising strategy for cancer treatment with the ability for deep tissue penetration, has received widespread attention in recent years. Sonosensitizers with intrinsic characteristics for tumor-specific curative...
3D nanofiber scaffolds from 2D electrospun membranes boost cell penetration and positive host response for regenerative medicine [0.03%]
用于再生医学的三维纳米纤维支架可增强细胞穿透和宿主正向反应二维静电纺丝膜
Lingfei Xiao,Huifan Liu,Huayi Huang et al.
Lingfei Xiao et al.
The ideal tissue engineering scaffold should facilitate rapid cell infiltration and provide an optimal immune microenvironment during interactions with the host. Electrospinning can produce two-dimensional (2D) membranes mimicking the extra...
NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging [0.03%]
近红外线触发的聚多巴胺包覆的二氧化铈纳米酶通过增强ROS清除来改善急性肺损伤
Mingjing Yin,Doudou Lei,Yalan Liu et al.
Mingjing Yin et al.
Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) and inflammatory factors levels in the lung. Multiple evidences suggest that nanozyme with divers...
Mussel-inspired immunomodulatory and osteoinductive dual-functional hydroxyapatite nanoplatform for promoting bone regeneration [0.03%]
一种促进骨再生的基于羟基磷灰石的仿贻贝壳多级纳米复合材料免疫调控及成骨双功能平台
Danlei Qin,Yifan Zhao,Rui Cheng et al.
Danlei Qin et al.
Simultaneously modulating the inflammatory microenvironment and promoting local bone regeneration is one of the main challenges in treating bone defects. In recent years, osteoimmunology has revealed that the immune system plays an essentia...
Recent advances in the use of extracellular vesicles from adipose-derived stem cells for regenerative medical therapeutics [0.03%]
近期来自脂肪源性干细胞的细胞外囊泡用于再生医疗治疗的研究进展
Song Yang,Yiran Sun,Chenchen Yan
Song Yang
Adipose-derived stem cells (ADSCs) are a subset of mesenchymal stem cells (MSCs) isolated from adipose tissue. They possess remarkable properties, including multipotency, self-renewal, and easy clinical availability. ADSCs are also capable ...
ZNPs reduce epidermal mechanical strain resistance by promoting desmosomal cadherin endocytosis via mTORC1-TFEB-BLOC1S3 axis [0.03%]
锌指蛋白通过mTORC1-TFEB-BLOC1S3轴促进盘状大肠杆菌内吞作用，从而降低表皮机械抗张力抵抗力
Xuan Lai,Menglei Wang,Zhen Zhang et al.
Xuan Lai et al.
Zinc oxide nanoparticles (ZNPs) are widely used in sunscreens and nanomedicines, and it was recently confirmed that ZNPs can penetrate stratum corneum into deep epidermis. Therefore, it is necessary to determine the impact of ZNPs on epider...