S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis [0.03%]
来源于间充质干细胞经S-RBD修饰和miR-486-5p工程化的外泌体通过抑制铁死亡改善放射性肺损伤及长期肺纤维化
Wei-Yuan Zhang,Li Wen,Li Du et al.
Wei-Yuan Zhang et al.
Background: Radiation-induced lung injury (RILI) is associated with alveolar epithelial cell death and secondary fibrosis in injured lung. Mesenchymal stem cell (MSC)-derived exosomes have regenerative effect against lung...
Asim Mushtaq,Muhammad Zubair Iqbal,Jianbin Tang et al.
Asim Mushtaq et al.
Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments to address this significant medical and societal challenge. In recent years, X-ray-in...
Multifunctional nanoplatform with near-infrared triggered nitric-oxide release for enhanced tumor ferroptosis [0.03%]
具有近红外触发一氧化氮释放的多功能纳米平台促进肿瘤铁死亡增强效应
Min Wang,Zhuangli Zhang,Qianqian Li et al.
Min Wang et al.
Ferroptosis has emerged as a promising strategy for cancer treatment. Nevertheless, the efficiency of ferroptosis-mediated therapy remains a challenge due to high glutathione (GSH) levels and insufficient endogenous hydrogen peroxide in the...
Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration [0.03%]
靶向骨关节炎中的FAP阳性软骨细胞：一种新的脂质纳米颗粒siRNA方法，以减轻软骨退变
Xiang Zhao,Jieming Lin,Mingyang Liu et al.
Xiang Zhao et al.
Background: Osteoarthritis (OA) is a common joint disease that leads to chronic pain and functional limitations. Recent research has revealed soluble fibroblast activation protein (FAP) secreted from OA synovium could deg...
Islet cell spheroids produced by a thermally sensitive scaffold: a new diabetes treatment [0.03%]
由热敏支架产生的胰岛细胞聚合体：一种新的糖尿病治疗方法
Xueting Yao,Zehua Gong,Wenyan Yin et al.
Xueting Yao et al.
The primary issues in treating type 1 diabetes mellitus (T1DM) through the transplantation of healthy islets or islet β-cells are graft rejection and a lack of available donors. Currently, the majority of approaches use cell encapsulation ...
AuCePt porous hollow cascade nanozymes targeted delivery of disulfiram for alleviating hepatic insulin resistance [0.03%]
负载戒酒硫的AuCePt多级中空纳米酶协同改善肝脏胰岛素抵抗作用研究
Huawei Shen,Yafei Fu,Feifei Liu et al.
Huawei Shen et al.
As the pathophysiological basis of type 2 diabetes mellitus (T2DM), insulin resistance (IR) is closely related to oxidative stress (OS) and inflammation, while nanozymes have a good therapeutic effect on inflammation and OS by scavenging re...
Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5 [0.03%]
巨噬细胞凋亡小体通过递送miR-143-3p靶向Igfbp5促进牙周炎骨吸收
Junhong Xiao,Yifei Deng,Jirong Xie et al.
Junhong Xiao et al.
Abstrct: BACKGROUND: Apoptotic vesicles (ApoVs), which are extracellular vesicles released by apoptotic cells, have been reported to exhibit substantial therapeutic potential for inflammatory diseases and tissue regenerat...
Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years [0.03%]
纳米抗体的发现：过去五年里应用和潜力的全面回顾
Elena Alexander,Kam W Leong
Elena Alexander
Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies found in the Camelidae family as well as cartilaginous fish. Their unique structural and functional properties, such as their small size, the ability to be...
m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia [0.03%]
circHIF1α通过与IGF2BP3蛋白KH结构域结合介导DNA损伤及G1/S期阻滞抵抗菌血症细菌感染的新机制研究
Jiang Yu,Yidan Gao,Fei Liu et al.
Jiang Yu et al.
Background: Animal and human health are seriously threatened by bacterial infections, which can lead to bacteremia and extremely high rates of morbidity and mortality. Recently, there have been reports indicating the invo...
Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration [0.03%]
用于气管粘膜再生的具有组织粘附、抗菌和促血管生成性能的铜氢磷酸盐纳米片功能化水凝胶
Pengli Wang,Erji Gao,Tao Wang et al.
Pengli Wang et al.
Timely and effective interventions after tracheal mucosal injury are lack in clinical practices, which elevate the risks of airway infection, tracheal cartilage deterioration, and even asphyxiated death. Herein, we proposed a biomaterial-ba...