Apoptosis and cuproptosis Co-activated Copper-based metal-organic frameworks for cancer therapy [0.03%]
用于癌症治疗的凋亡和铜依赖性细胞死亡共激活的铜基金属有机框架
Kun Li,Leilei Wu,Han Wang et al.
Kun Li et al.
Lung cancer, predominantly non-small cell lung cancer (NSCLC), remains a significant global health challenge, with limited therapeutic options for patients with KRAS-mutated tumors. Herein, a copper-based metal-organic framework (Cu-MOF) wa...
A carbon dot nanozyme hydrogel enhances pulp regeneration activity by regulating oxidative stress in dental pulpitis [0.03%]
一种碳点纳米酶水凝胶通过调节牙髓炎中的氧化应激增强牙髓再生活性
Yingjuan Zhang,Xianxian Huang,Yicai Luo et al.
Yingjuan Zhang et al.
Preserving pulp viability and promoting pulp regeneration in pulpitis have attracted widespread attention. Restricted by the oxidative stress microenvironment of dental pulpitis, excessive reactive oxygen and nitrogen species (RONS) trigger...
Berberine and magnolol exert cooperative effects on ulcerative colitis in mice by self-assembling into carrier-free nanostructures [0.03%]
小分子自组装纳米结构协同治疗结肠炎研究
Yida Xu,Zhejie Chen,Wei Hao et al.
Yida Xu et al.
The risk of ulcerative colitis (UC) is increasing worldwide with limited success using classical drugs, which has underscored the development of novel agents. Recently, carrier-free molecular assembly has been proven to be an effective drug...
MiR-100-5p-rich small extracellular vesicles from activated neuron to aggravate microglial activation and neuronal activity after stroke [0.03%]
富集miR-100-5p的小细胞外囊泡通过活化神经元加剧卒中后的小胶质细胞活化和神经元活性
Danqing Xin,Tingting Li,Yijing Zhao et al.
Danqing Xin et al.
Ischemic stroke is a common cause of mortality and severe disability in human and currently lacks effective treatment. Neuronal activation and neuroinflammation are the major two causes of neuronal damage. However, little is known about the...
Tumor microenvironment-responsive manganese-based nano-modulator activate the cGAS-STING pathway to enhance innate immune system response [0.03%]
肿瘤微环境响应型锰基纳米调控剂激活cGAS-STING通路以增强先天免疫系统应答
Xiayi Liang,Duo Wang,Yuanquan Zhao et al.
Xiayi Liang et al.
Background: Manganese ions (Mn2+) combined with adjuvants capable of damaging and lysing tumor cells form an antitumor nano-modulator that enhances the immune efficacy of cancer therapy through the cascade activation of t...
Susu Xiao,Min Mu,Chenqian Feng et al.
Susu Xiao et al.
Adverse effects and multidrug resistance remain significant obstacles in conventional cancer therapy. Nanomedicines, with their intrinsic properties such as nano-sized dimensions and tunable surface characteristics, have the potential to mi...
Ferroptosis-inducing nanomedicine and targeted short peptide for synergistic treatment of hepatocellular carcinoma [0.03%]
用于肝细胞癌协同治疗的促铁死亡纳米药物和靶向短肽
Luyang Wang,Le Tong,Zecheng Xiong et al.
Luyang Wang et al.
The poor prognosis of hepatocellular carcinoma (HCC) is still an urgent challenge to be solved worldwide. Hence, assembling drugs and targeted short peptides together to construct a novel medicine delivery strategy is crucial for targeted a...
Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells [0.03%]
纳米硅酸盐通过激活牙周膜细胞的PI3K-AKT信号通路促进牙周再生潜力
Ziqin Chen,Nianqi Xiao,Lan Luo et al.
Ziqin Chen et al.
The recent development of nanobiomaterials has shed some light on the field of periodontal tissue regeneration. Laponite (LAP), an artificially synthesized two-dimensional (2D) disk-shaped nanosilicate, has garnered substantial attention in...
Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing [0.03%]
用于糖尿病伤口管理的内源性电场耦合Mxene海绵：止血、抗菌和促进愈合
Hai Zhou,Lianglong Chen,Chaoyang Huang et al.
Hai Zhou et al.
Improper management of diabetic wound effusion and disruption of the endogenous electric field can lead to passive healing of damaged tissue, affecting the process of tissue cascade repair. This study developed an extracellular matrix spong...
Aminolysis-mediated single-step surface functionalization of poly (butyl cyanoacrylate) microbubbles for ultrasound molecular imaging [0.03%]
基于氨基醇解的单步表面修饰聚氰基丙烯酸丁酯微泡制备用于超声分子成像的靶向造影剂
Junlin Chen,Bi Wang,Anshuman Dasgupta et al.
Junlin Chen et al.
Molecular ultrasound imaging with actively targeted microbubbles (MB) proved promising in preclinical studies but its clinical translation is limited. To achieve this, it is essential that the actively targeted MB can be produced with high ...