MSC-microvesicles protect cartilage from degradation in early rheumatoid arthritis via immunoregulation [0.03%]
MSC微囊通过免疫调节在早期类风湿关节炎中保护软骨免于退化
Shixiong Wei,Rui-Juan Cheng,Sujia Li et al.
Shixiong Wei et al.
Objective: As research into preclinical rheumatoid arthritis (pre-RA) has advanced, a growing body of evidence suggests that abnormalities in RA-affected joint cartilage precede the onset of arthritis. Thus, early prevent...
Magnetic 3D macroporous MOF oriented urinary exosome metabolomics for early diagnosis of bladder cancer [0.03%]
磁性三维宏观孔MOFs用于尿外泌体代谢组学以实现膀胱癌的早期诊断
Yiqing Cao,Jianan Feng,Qiao Zhang et al.
Yiqing Cao et al.
Bladder cancer (BCa) exhibits the escalating incidence and mortality due to the untimely and inaccurate early diagnosis. Urinary exosome metabolites, carrying critical tumor cell information and directly related to bladder, emerge as promis...
Intestinal nanoparticle delivery and cellular response: a review of the bidirectional nanoparticle-cell interplay in mucosa based on physiochemical properties [0.03%]
肠道纳米药物递送及细胞响应：基于理化性质的双向纳米粒子-细胞相互作用在黏膜中的综述研究
Yu Wang,Yilei Mo,Yingwei Sun et al.
Yu Wang et al.
Orally administered nanocarriers play an important role in improving druggability, promoting intestinal absorption, and enhancing therapeutic applications for the treatment of local and systemic diseases. However, the delivering efficiency ...
Proton nanomodulators for enhanced Mn2+-mediated chemodynamic therapy of tumors via HCO3- regulation [0.03%]
通过调节HCO3-增强Mn2+介导的化疗动力学疗法的质子纳米调控剂
Peng Yang,Shaojie Liu,Zhuang Chen et al.
Peng Yang et al.
Background: Mn2+-mediated chemodynamic therapy (CDT) has been emerged as a promising cancer therapeutic modality that relies heavily on HCO3- level in the system. Although the physiological buffers (H2CO3/HCO3-) provide c...
Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection [0.03%]
用于治疗多重耐药细菌感染的抗菌肽自组装体系
Xuanxuan Ma,Na Yang,Ruoyu Mao et al.
Xuanxuan Ma et al.
The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application. He...
Losartan-based nanocomposite hydrogel overcomes chemo-immunotherapy resistance by remodeling tumor mechanical microenvironment [0.03%]
基于洛萨坦的纳米复合水凝胶通过重塑肿瘤机械微环境来克服化疗免疫治疗耐药性
Xiaodong Hou,Yuting Shen,Bin Huang et al.
Xiaodong Hou et al.
Preclinical studies demonstrating high cure rates with PD1/PD-L1 combinations have led to numerous clinical trials, but emerging results are disappointing. These combined immunotherapies are commonly employed for patients with refractory tu...
Magnetic vagus nerve stimulation ameliorates contrast-induced acute kidney injury by circulating plasma exosomal miR-365-3p [0.03%]
磁性迷走神经刺激通过循环血浆外泌体miR-365-3p改善对比剂介导的急性肾损伤
Tianyu Wu,Wenwu Zhu,Rui Duan et al.
Tianyu Wu et al.
Background: Contrast-induced acute kidney injury (CI-AKI) is manifested by a rapid decline in renal function occurring within 48-72 h in patients exposed to iodinated contrast media (CM). Although intravenous hydration is...
Magnetic targeting enhances the neuroprotective function of human mesenchymal stem cell-derived iron oxide exosomes by delivering miR-1228-5p [0.03%]
磁性靶向通过递送miR-1228-5p增强人间充质干细胞源铁氧体外泌体的神经保护功能
Wei-Jia Hu,Hong Wei,Li-Li Cai et al.
Wei-Jia Hu et al.
Background: Treating mitochondrial dysfunction is a promising approach for the treatment of post-stroke cognitive impairment (PSCI). HuMSC-derived exosomes (H-Ex) have shown powerful therapeutic effects in improving mitoc...
Macrophage membrane-functionalized manganese dioxide nanomedicine for synergistic treatment of atherosclerosis by mitigating inflammatory storms and promoting cholesterol efflux [0.03%]
用于缓解炎症风暴和促进胆固醇流出协同治疗动脉粥样硬化的巨噬细胞膜功能化锰 dioxide 纳米药物
Sijin Chen,Wenli Zhang,Chun Tang et al.
Sijin Chen et al.
Atherosclerosis (AS) poses a significant threat to human life and health. However, conventional antiatherogenic medications exhibit insufficient targeting precision and restricted therapeutic effectiveness. Moreover, during the progression ...
Engineering dendritic cell biomimetic membrane as a delivery system for tumor targeted therapy [0.03%]
工程化仿树突状细胞膜作为肿瘤靶向治疗的输送系统
Huiyang Liu,Yiming Lu,Jinbao Zong et al.
Huiyang Liu et al.
Targeted immunotherapies make substantial strides in clinical cancer care due to their ability to counteract the tumor's capacity to suppress immune responses. Advances in biomimetic technology with minimally immunogenic and highly targeted...