Evaluating the pro-survival potential of apoptotic bodies derived from 2D- and 3D- cultured adipose stem cells in ischaemic flaps [0.03%]
评估来自二维和三维培养的脂肪干细胞的凋亡体在缺血皮瓣中的促生存潜力
Gaoxiang Yu,Jian Ding,Ningning Yang et al.
Gaoxiang Yu et al.
In the realm of large-area trauma flap transplantation, averting ischaemic necrosis emerges as a pivotal concern. Several key mechanisms, including the promotion of angiogenesis, the inhibition of oxidative stress, the suppression of cell d...
A cascade nanosystem with "Triple-Linkage" effect for enhanced photothermal and activatable metal ion therapy for hepatocellular carcinoma [0.03%]
一种具有“三联效应”的级联纳米系统用于增强光热和可激活金属离子的肝细胞癌治疗
Shuo Yu,Huan Shen,Xi Chen et al.
Shuo Yu et al.
Due to the limitations of single-model tumor therapeutic strategies, multimodal combination therapy have become a more favorable option to enhance efficacy by compensating for its deficiencies. However, in nanomaterial-based multimodal ther...
Upconversion nanoparticles doped optical lens: let's see the near-infrared light [0.03%]
掺杂上转换纳米颗粒的光学透镜：让我们来看近红外光吧
Yulin Hu,Baoqi Xu,Wei Li et al.
Yulin Hu et al.
The human cannot detect light with a wavelength exceeding 700 nm, primarily due to limitations in the physiological structure of the human eye. However, in certain specific scenarios, the ability to detect near-infrared (NIR) light proves t...
Epithelium-derived exosomes promote silica nanoparticles-induced pulmonary fibroblast activation and collagen deposition via modulating fibrotic signaling pathways and their epigenetic regulations [0.03%]
上皮细胞源性外泌体通过调节纤维化信号通路及表观遗传调控促进二氧化硅纳米颗粒致肺成纤维细胞活化和胶原沉积
Yan Li,Hailin Xu,Ying Wang et al.
Yan Li et al.
Background: In the context of increasing exposure to silica nanoparticles (SiNPs) and ensuing respiratory health risks, emerging evidence has suggested that SiNPs can cause a series of pathological lung injuries, includin...
De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation [0.03%]
用于冷冻保存和移植的卵巢组织动态修复的从头设计纳米调节器
Min Jiang,Guo-Hui Zhang,Yuan Yu et al.
Min Jiang et al.
The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovarian tissue cryopreservation and...
Bacterial outer membrane vesicle-cancer cell hybrid membrane-coated nanoparticles for sonodynamic therapy in the treatment of breast cancer bone metastasis [0.03%]
用于乳腺癌骨转移声动力治疗的细菌外膜囊-癌细胞杂化膜包被纳米粒子
Jiahao Wang,Shuailong Liang,Sijie Chen et al.
Jiahao Wang et al.
Breast cancer bone metastasis is a terminal-stage disease and is typically treated with radiotherapy and chemotherapy, which causes severe side effects and limited effectiveness. To improve this, Sonodynamic therapy may be a more safe and e...
Liposome-lentivirus for miRNA therapy with molecular mechanism study [0.03%]
用于微小核糖核酸治疗的脂质体- lentiviruses及其分子机制研究
Fen Sun,Huaqing Chen,Xiaoyong Dai et al.
Fen Sun et al.
Background: Cancer stem cells (CSCs) play a vital role in the occurrence, maintenance, and recurrence of solid tumors. Although, miR-145-5p can inhibit CSCs survival, poor understanding of the underlying mechanisms hamper...
Attenuation of osteoarthritis progression via locoregional delivery of Klotho-expressing plasmid DNA and Tanshinon IIA through a stem cell-homing hydrogel [0.03%]
通过干细胞归巢水凝胶局部递送表达Klotho基因的质粒DNA和丹参素IIA缓释以缓解骨关节炎进展
Peng Wang,Zhibo Zhao,Ziyang Li et al.
Peng Wang et al.
Background: Osteoarthritis (OA) is an aging-related degenerative joint disorder marked by joint discomfort and rigidity. Senescent chondrocytes release pro-inflammatory cytokines and extracellular matrix-degrading protein...
pH/GSH dual-responsive nanoparticle for auto-amplified tumor therapy of breast cancer [0.03%]
用于自动放大的乳腺肿瘤治疗的pH/GSH双响应型纳米粒子
Shengnan Huang,Zhiling Xu,Weiwei Zhi et al.
Shengnan Huang et al.
Breast cancer remains a malignancy that poses a serious threat to human health worldwide. Chemotherapy is one of the most widely effective cancer treatments in clinical practice, but it has some drawbacks such as poor targeting, high toxici...
Magnetogenetics as a promising tool for controlling cellular signaling pathways [0.03%]
磁遗传学作为控制细胞信号转导通路的有力工具
Anastasiia A Latypova,Alexey V Yaremenko,Nadezhda A Pechnikova et al.
Anastasiia A Latypova et al.
Magnetogenetics emerges as a transformative approach for modulating cellular signaling pathways through the strategic application of magnetic fields and nanoparticles. This technique leverages the unique properties of magnetic nanoparticles...