A nanoscale visual exploration of the pathogenic effects of bacterial extracellular vesicles on host cells [0.03%]
细菌外泌体感染宿主细胞致病性的纳米视觉探索
Minjae Kang,Min Jeong Kim,Dokyung Jeong et al.
Minjae Kang et al.
Background: Bacterial extracellular vesicles (EVs) are pivotal mediators of intercellular communication and influence host cell biology, thereby contributing to the pathogenesis of infections. Despite their significance, ...
Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis [0.03%]
透明质酸包被的聚肽纳米凝胶增强Tacrolimus治疗类风湿性关节炎的靶向分布与疗效研究
Yuhuan Li,Xin Wang,Yu Gao et al.
Yuhuan Li et al.
Rheumatoid arthritis (RA) involves chronic inflammation, oxidative stress, and complex immune cell interactions, leading to joint destruction. Traditional treatments are often limited by off-target effects and systemic toxicity. This study ...
GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor [0.03%]
一种基于PD-1抑制的增效光免疫疗法协同响应型聚合物胶束化制剂，用于激发强烈抗结肠肿瘤免疫力
Chenlu Huang,Xinyu Yang,Huidong Li et al.
Chenlu Huang et al.
Phototherapy is a promising antitumor modality, which consists of photothermal therapy (PTT) and photodynamic therapy (PDT). However, the efficacy of phototherapy is dramatically hampered by local hypoxia in tumors, overexpression of indole...
Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis [0.03%]
用于改善溃疡性结肠炎的肠道平衡的口服仿生金属酚纳米酶具有四重保障
Yuanyuan Zhu,Xiaoling Huang,Zhichao Deng et al.
Yuanyuan Zhu et al.
Background: Ulcerative colitis (UC) is defined by persistent inflammatory processes within the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in their ability to address oxidative...
Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics [0.03%]
年轻的小细胞外囊泡通过重塑Drp1易位介导的线粒体动力学来逆转复制性衰老
Yingying Peng,Tingting Zhao,Shuxuan Rong et al.
Yingying Peng et al.
Background: Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials. In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal s...
Apoptotic vesicles (apoVs) derived from fibroblast-converted hepatocyte-like cells effectively ameliorate liver fibrosis [0.03%]
由成纤维细胞转化的肝细胞样细胞来源的凋亡小体有效改善肝纤维化
Zhi Zhong,Xiu-Liang Cui,Kun-Jiang Tan et al.
Zhi Zhong et al.
Liver fibrosis is a serious global health issue for which effective treatment remains elusive. Chemical-induced hepatocyte-like cells (ciHeps) have emerged as an appealing source for cell transplantation therapy, although they present sever...
Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway [0.03%]
超声波触发压电聚醚醚酮促进骨发生的作用及机制研究
Yue Li,Yingying Fan,Siyu Zhao et al.
Yue Li et al.
Maxillofacial bone defects can severely impact quality of life by impairing physiological functions such as chewing, breathing, swallowing, and pronunciation. Polyether ether ketone (PEEK) is commonly used for the repair of maxillofacial de...
Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis [0.03%]
TCOF1/FLVCR1介导的线粒体稳态调节物可缓解衰老相关骨老化表型
Yan Qu,Bowen Meng,Simin Cai et al.
Yan Qu et al.
Over 50 billion cells undergo apoptosis each day in an adult human to maintain tissue homeostasis by eliminating damaged or unwanted cells. Apoptotic deficiency can lead to age-related diseases with reduced apoptotic metabolites. However, w...
Nanoparticle LDH enhances RNAi efficiency of dsRNA in piercing-sucking pests by promoting dsRNA stability and transport in plants [0.03%]
纳米LDH促进植物介导双链rna的稳定性及传输从而提高刺吸式害虫的RNA干扰效率
Xiaoqin Cheng,Qi Zhou,Jiedan Xiao et al.
Xiaoqin Cheng et al.
Piercing-sucking pests are the most notorious group of pests for global agriculture. RNAi-mediated crop protection by foliar application is a promising approach in field trials. However, the effect of this approach on piercing-sucking pests...
Enhanced osteogenic differentiation in 3D hydrogel scaffold via macrophage mitochondrial transfer [0.03%]
巨噬细胞线粒体转移促进三维水凝胶支架中的成骨分化
Shui Qiu,Lili Cao,Dingding Xiang et al.
Shui Qiu et al.
To assess the efficacy of a novel 3D biomimetic hydrogel scaffold with immunomodulatory properties in promoting fracture healing. Immunomodulatory scaffolds were used in cell experiments, osteotomy mice treatment, and single-cell transcript...