A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs [0.03%]
一种新型球形GelMA-HAMA水凝胶，内含APET×2多肽和CFIm25靶向sgRNA，用于调制免疫微环境和椎间盘髓核再生
Xiao-Jun Yu,Yuan-Ting Zhao,Haimiti Abudouaini et al.
Xiao-Jun Yu et al.
Methods: Single-cell transcriptomics and high-throughput transcriptomics were used to screen factors significantly correlated with intervertebral disc degeneration (IDD). Expression changes of CFIm25 were determined via R...
Preparation and effects of functionalized liposomes targeting breast cancer tumors using chemotherapy, phototherapy, and immunotherapy [0.03%]
用于乳腺癌肿瘤的化疗、光动力治疗和免疫治疗的功能化脂质体的制备及其效果研究
Bowen Zeng,Lina Pian,Yanhong Liu et al.
Bowen Zeng et al.
Breast cancer therapy has significantly advanced by targeting the programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway. BMS-202 (a smallmolecule PD-L1 inhibitor) induces PD-L1 dimerization to block PD-1/PD-L1 interact...
ACYP2 functions as an innovative nano-therapeutic target to impede the progression of hepatocellular carcinoma by inhibiting the activity of TERT and the KCNN4/ERK pathway [0.03%]
ACYP2作为抗肝癌纳米治疗靶点通过抑制TERT活性及KCNN4/ERK通路发挥抑瘤作用
Yixuan Wu,Hongyi Bao,Jinran Wu et al.
Yixuan Wu et al.
An increasing body of evidence suggests that acylphosphatase-2 (ACYP2) polymorphisms are correlated with an increased susceptibility to a range of malignancies. Nevertheless, its potential functions, molecular mechanisms in hepatocellular c...
Fei Guo,Yizhan Wu,Jiangwei Liu
Fei Guo
Objective: The exacerbation of extreme high-temperature events due to global climate change poses a significant challenge to public health, particularly impacting the central nervous system through heat stroke. This study...
Ellagic acid-enhanced biocompatibility and bioactivity in multilayer core-shell gold nanoparticles for ameliorating myocardial infarction injury [0.03%]
ellagic酸增强的多层核壳型金纳米颗粒的生物相容性和生物活性可改善心肌梗死损伤
Xina Yu,Jie Wang,Tiantian Wang et al.
Xina Yu et al.
Background: Myocardial infarction (MI) is the main contributor to most cardiovascular diseases (CVDs), and the available post-treatment clinical therapeutic options are limited. The development of nanoscale drug delivery ...
Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis [0.03%]
TNF-α预处理的IPFP-MSCs来源的工程外泌体可提高骨关节炎治疗效果及分泌量
Jiangyi Wu,Jinhui Wu,Wei Xiang et al.
Jiangyi Wu et al.
Background: The pathogenesis of osteoarthritis (OA) involves the progressive degradation of articular cartilage. Exosomes derived from mesenchymal stem cells (MSC-EXOs) have been shown to mitigate joint pathological injur...
Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA [0.03%]
脂质纳米颗粒(LNPs)大小、表面电荷和PEG化脂质对肌肉内递送mRNA的影响
Weiwen Kong,Yuning Wei,Zirong Dong et al.
Weiwen Kong et al.
Lipid nanoparticles (LNPs) are currently the most commonly used non-viral gene delivery system. Their physiochemical attributes, encompassing size, charge and surface modifications, significantly affect their behaviors both in vivo and in v...
Non-viral approaches in CAR-NK cell engineering: connecting natural killer cell biology and gene delivery [0.03%]
非病毒型CAR-NK细胞工程方法：衔接自然杀伤细胞生物学与基因传递
Emma M McErlean,Helen O McCarthy
Emma M McErlean
Natural Killer (NK) cells are exciting candidates for cancer immunotherapy with potent innate cytotoxicity and distinct advantages over T cells for Chimeric Antigen Receptor (CAR) therapy. Concerns regarding the safety, cost, and scalabilit...
Rationally designed catalytic nanoplatform for enhanced chemoimmunotherapy via deploying endogenous plus exogenous copper and remodeling tumor microenvironment [0.03%]
通过部署内源性加上外源性铜和重塑肿瘤微环境来增强化学免疫治疗的合理设计催化纳米平台
Daxi Sun,Liting Yu,Gang Wang et al.
Daxi Sun et al.
Chemodynamic therapy represents a novel tumor therapeutic modality via triggering catalytic reactions in tumors to yield highly toxic reactive oxygen species (ROS). Nevertheless, low efficiency catalytic ability, potential systemic toxicity...
GelMA loaded with exosomes from human minor salivary gland organoids enhances wound healing by inducing macrophage polarization [0.03%]
人源小唾液腺类器官衍生的外泌体修饰明胶美得舒水凝胶通过诱导巨噬细胞极化促进伤口愈合
Jiaying Qian,Enhang Lu,Haibo Xiang et al.
Jiaying Qian et al.
Non-healing skin wounds pose significant clinical challenges, with biologic products like exosomes showing promise for wound healing. Saliva and saliva-derived exosomes, known to accelerate wound repair, yet their extraction is difficult du...