Targeting SUMOylation with an injectable nanocomposite hydrogel to optimize radiofrequency ablation therapy for hepatocellular carcinoma [0.03%]
一种用于优化肝细胞癌射频消融治疗的可注射型纳米复合水凝胶以靶向SUMO化
Junfeng Liu,Xi Li,Jiawen Chen et al.
Junfeng Liu et al.
Background: Incomplete radiofrequency ablation (iRFA) in hepatocellular carcinoma (HCC) often leads to local recurrence and distant metastasis of the residual tumor. This is closely linked to the development of a tumor im...
Single-cell RNA transcriptomic reveal the mechanism of MSC derived small extracellular vesicles against DKD fibrosis [0.03%]
单细胞RNA测序揭示MSC来源的小胞外囊泡抗DKD纤维化机制
Cheng Ji,Jiahui Zhang,Hui Shi et al.
Cheng Ji et al.
Diabetic kidney disease (DKD), a chronic kidney disease, is characterized by progressive fibrosis caused due to persistent hyperglycemia. The development of fibrosis in DKD determines the patient prognosis, but no particularly effective tre...
3D stem-like spheroids-on-a-chip for personalized combinatorial drug testing in oral cancer [0.03%]
用于口腔癌个性化组合药物筛查的三维癌症干细胞类器官芯片技术
Viraj Mehta,Sukanya Vilikkathala Sudhakaran,Vijaykumar Nellore et al.
Viraj Mehta et al.
Background: Functional drug testing (FDT) with patient-derived tumor cells in microfluidic devices is gaining popularity. However, the majority of previously reported microfluidic devices for FDT were limited by at least ...
Xinqing Hao,Shiming Wang,Liang Wang et al.
Xinqing Hao et al.
Recently, the significant benefits of cancer immunotherapy for most cancers have been demonstrated in clinical and preclinical studies. However, the efficacy of these immunotherapies for gliomas is limited, owing to restricted drug delivery...
Advances in nanomaterial-targeted treatment of acute lung injury after burns [0.03%]
纳米材料靶向治疗烧伤后急性肺损伤的研究进展
Shuo Zhang,Xinyu Zhao,Yuhao Xue et al.
Shuo Zhang et al.
Acute lung injury (ALI) is a common complication in patients with severe burns and has a complex pathogenesis and high morbidity and mortality rates. A variety of drugs have been identified in the clinic for the treatment of ALI, but they h...
Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration [0.03%]
高效抑炎和修复基质软骨再生的细胞系外泌体细胞免费策略治疗骨关节炎研究
Kai Feng,Feng Wang,Hongfang Chen et al.
Kai Feng et al.
Osteoarthritis (OA) is a common degenerative joint disease which currently lacks of effective agents. It is therefore urgent and necessary to seek an effective approach that can inhibit inflammation and promote cartilage matrix homeostasis....
Engineering nanoparticles-enabled tumor-associated macrophages repolarization and phagocytosis restoration for enhanced cancer immunotherapy [0.03%]
利用工程化纳米颗粒重编程肿瘤相关巨噬细胞以增强癌症免疫治疗
Yonghua Gong,Wenyue Gao,Jinyang Zhang et al.
Yonghua Gong et al.
Tumor-associated macrophages (TAMs) are pivotal within the immunosuppressive tumor microenvironment (TME), and recently, have attracted intensive attention for cancer treatment. However, concurrently to promote TAMs repolarization and phago...
Chiral MoS2@BC fibrous membranes selectively promote peripheral nerve regeneration [0.03%]
手性MoS2@BC纤维膜可促进外周神经选择性再生
Mengru Li,Xiao Li,Yaowei Lv et al.
Mengru Li et al.
Background: Molybdenum disulfide (MoS2) has excellent physical and chemical properties. Further, chiral MoS2 (CMS) exhibits excellent chiroptical and enantioselective effects, and the enantioselective properties of CMS ha...
Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives [0.03%]
纳米材料相关血红蛋白氧载体研究（以脂质体和纳米胶囊为重点）：现状与未来展望
Kai Zhu,Lijun Wang,Yao Xiao et al.
Kai Zhu et al.
Oxygen is necessary for life and plays a key pivotal in maintaining normal physiological functions and treat of diseases. Hemoglobin-based oxygen carriers (HBOCs) have been studied and developed as a replacement for red blood cells (RBCs) i...
Peiying Huang,Qinglai Tang,Mengmeng Li et al.
Peiying Huang et al.
Manganese (Mn) is widely recognized owing to its low cost, non-toxic nature, and versatile oxidation states, leading to the emergence of various Mn-based nanomaterials with applications across diverse fields, particularly in tumor diagnosis...