Organoids and organoid extracellular vesicles-based disease treatment strategies [0.03%]
基于类器官和类器官外泌体的疾病治疗策略
Guangyin Zhou,Ruiyang Li,Shihao Sheng et al.
Guangyin Zhou et al.
Organoids are "mini-organs" that self-organize and differentiate from stem cells under in vitro 3D culture conditions, mimicking the spatial structure and function of tissues in vivo. Extracellular vesicles (EVs) are nanoscale phospholipid ...
Cascade-catalysed nanocarrier degradation for regulating metabolism homeostasis and enhancing drug penetration on breast cancer [0.03%]
级联催化型纳米药物递送系统用于调节代谢稳态并增强乳腺癌治疗药物渗透性
Fang Zhang,Kai Cheng,Xiao-Shuai Zhang et al.
Fang Zhang et al.
The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy. Herein, an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed, which can dilate vessle and im...
A temperature-ultrasound sensitive nanoparticle delivery system for exploring central neuroinflammation mechanism in stroke-heart syndrome [0.03%]
一种温度-超声敏感的纳米颗粒递送系统用于探究中风心脏综合征中枢神经炎症机制
Mingzhou Jiang,Zhidong Zhu,Ziyu Zhou et al.
Mingzhou Jiang et al.
Background: Cardiovascular events secondary to stroke-collectively classified as stroke-heart syndrome-greatly impair the patient's prognosis, however its underlying mechanism has yet to be determined. To investigate the ...
Tetrahedral framework nucleic acids inhibit Aβ-mediated ferroptosis and ameliorate cognitive and synaptic impairments in Alzheimer's disease [0.03%]
四面体框架核酸抑制阿尔茨海默病中的Aβ介导的铁死亡及认知和突触损伤改善
Lu Tan,Jiazhao Xie,Chenqi Liao et al.
Lu Tan et al.
Background: Ferroptosis represents a nonapoptotic type of programmed cell death induced by excessive intracellular iron accumulation. Ferroptosis is an essential driver of the pathogenesis of Alzheimer's disease (AD). Tet...
IFITM1 is a host restriction factor that inhibits porcine epidemic diarrhea virus infection [0.03%]
IFITM1是抑制猪流行性腹泻病毒入侵的宿主限制因子
Jiahao Cheng,Jiayi He,Simeng Feng et al.
Jiahao Cheng et al.
Background: Porcine epidemic diarrhea virus (PEDV) infection and transmission pose a serious threat to the global swine industry. The search for a new host factor with anti-PEDV effect may be an effective potential target...
Recent advances of photoresponsive nanomaterials for diagnosis and treatment of acute kidney injury [0.03%]
用于急性肾损伤诊断和治疗的光响应纳米材料的研究进展
Shijie Yao,Yinan Wang,Xiaozhou Mou et al.
Shijie Yao et al.
Non-invasive imaging in the near-infrared region (NIR) offers enhanced tissue penetration, reduced spontaneous fluorescence of biological tissues, and improved signal-to-noise ratio (SNR), rendering it more suitable for in vivo deep tissue ...
A magnetic epitope-imprinted microsphere used for selective separation and rapid detection of SHV-type β-lactamases in bacteria: a novel strategy of antimicrobial resistance detection [0.03%]
一种用于选择性分离和快速检测细菌中SHV型β-内酰胺酶的磁性表位印迹微球：一种新的抗菌药物耐药性检测策略
Yusun Zhou,Kunqi Wang,Lele Li et al.
Yusun Zhou et al.
Background: The production of β-lactamases is the most prevalent resistance mechanism for β-lactam antibiotics in Gram-negative bacteria. Presently, over 4900 β-lactamases have been discovered, and they are categorized...
High-throughput synthesis and optimization of ionizable lipids through A3 coupling for efficient mRNA delivery [0.03%]
基于A3连接的手性离子化脂质的高通量合成和优化及其在mRNA递送中的应用
Jingjiao Li,Jie Hu,Danni Jin et al.
Jingjiao Li et al.
Background: The efficacy of mRNA-based vaccines and therapies relies on lipid nanoparticles (LNPs) as carriers to deliver mRNA into cells. The chemical structure of ionizable lipids (ILs) within LNPs is crucial in determi...
Retraction Note: A pH/enzyme dual responsive PMB spatiotemporal release hydrogel promoting chronic wound repair [0.03%]
撤稿说明：一种pH/酶双重响应的PMB时空释放水凝胶促进慢性伤口愈合
Lanlan Dong,Can Huang,Baohua Zhao et al.
Lanlan Dong et al.
Retraction of Publication
Journal of nanobiotechnology. 2024 Nov 5;22(1):675. DOI:10.1186/s12951-024-02960-0 2024
Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer [0.03%]
基于一氧化氮的多协同纳米药物：一种抗肿瘤新疗法
Yaqin Tang,Qiyu Li,Ziwei Zhou et al.
Yaqin Tang et al.
Gas therapy has emerged as a promising approach for treating cancer, with gases like NO, H2S, and CO showing positive effects. Among these, NO is considered a key gas molecule with significant potential in stopping cancer progression. Howev...