The progress and future of the treatment of Candida albicans infections based on nanotechnology [0.03%]
基于纳米技术的白色念珠菌感染诊疗研究进展与展望
Yang Gao,Qinyan Cao,Yuyang Xiao et al.
Yang Gao et al.
Systemic infection with Candida albicans poses a significant risk for people with weakened immune systems and carries a mortality rate of up to 60%. However, current therapeutic options have several limitations, including increasing drug to...
The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species [0.03%]
基于调节活性氧的纳米酶在骨科的生物医学应用
Xiangcheng Gao,Jiejie Zhang,Yining Gong et al.
Xiangcheng Gao et al.
Nanozymes, a category of nanomaterials with enzyme-like activity, have garnered growing interest in various biomedical contexts. Notably, nanozymes that are capable of regulating reactive oxygen species levels by emulating antioxidant or pr...
Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model [0.03%]
人胎盘和脐带血来源的外泌体对帕金森病小鼠模型多巴胺能神经元损伤的保护作用及机制研究
Junjie Ye,Xiaodong Sun,Qi Jiang et al.
Junjie Ye et al.
Background: Umbilical cord blood (UCB) is a rich source of multifunctional stem cells characterized by low immunogenicity. Recent research in the fields of aging and regenerative medicine has revealed the potential of hum...
Transformable self-delivered supramolecular nanomaterials combined with anti-PD-1 antibodies alleviate tumor immunosuppression to treat breast cancer with bone metastasis [0.03%]
可变形自我递送的超分子纳米材料结合抗PD-1抗体缓解免疫抑制治疗骨转移性乳腺癌
Xueying Liu,Hao Wang,Zhaofeng Li et al.
Xueying Liu et al.
Breast cancer is the most common malignant tumor that threatens women's life and health, and metastasis often occurs in the advanced stage of breast cancer, leading to pathological bone destruction and seriously reducing patient quality of ...
A nanobody-guided multifunctional T cell engager promotes strong anti-tumor responses via synergistic immuno-photothermal effects [0.03%]
一种纳米抗体引导的多功能T细胞结合剂可通过协同免疫光热效应促进强大的抗肿瘤反应
Shenxia Xie,Wei Shi,Siliang Duan et al.
Shenxia Xie et al.
Background: T cell-based immunotherapies are facing great challenges in the recruitment and activation of tumor-specific T cells against solid tumors. Among which, utilizing nanobody (Nb) or nanobodies (Nbs) to construct ...
A mucoadhesive-to-penetrating nanomotors-in-hydrogel system for urothelium-oriented intravesical drug delivery [0.03%]
一种用于尿路上药的粘附渗透性纳米马达-水凝胶系统
Bin Zheng,Haibao Zhang,Jinxue Wang et al.
Bin Zheng et al.
Intravesical therapy (IT) is widely used to tackle various urological diseases. However, its clinical efficacy is decreased by the impermeability of various barriers presented on the bladder luminal surface, including the urinary mucus laye...
Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis [0.03%]
重组铁蛋白基纳米颗粒作为neo抗原载体显著抑制肿瘤生长和转移
Wei Zheng,Shixiong Li,Zhongliang Shi et al.
Wei Zheng et al.
Background: Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a va...
Circ_0001947 encapsulated by small extracellular vesicles promotes gastric cancer progression and anti-PD-1 resistance by modulating CD8+ T cell exhaustion [0.03%]
小细胞外囊泡封装的环状circ_0001947通过调节CD8⁺T细胞衰竭促进胃癌进展和抗PD-1耐药性
Bingyu Wang,Wenbo Liu,Mingming Zhang et al.
Bingyu Wang et al.
Background: While small extracellular vesicles (sEVs)-derived circular RNAs (circRNAs) have been emerged as significant players in cancer, the function and underlying mechanism of sEVs-derived circRNAs in anti-cancer immu...
Multi-therapeutic-activity selenium nanodot toward preventing brain injury and restoring neurobehavioral functions following hemorrhagic stroke [0.03%]
预防出血性中风后的脑损伤和恢复神经行为功能的多效活性硒纳米点
Yibin Zhang,Xiaoyu Wang,Xuegang Niu et al.
Yibin Zhang et al.
Intracerebral hemorrhage is a lethal cerebrovascular disease, and the inevitable secondary brain injury (SBI) is responsible for serious disability and death. Perfect therapeutic goal is to minimize SBI and restore neurobehavioral functions...
Seed priming with graphene oxide improves salinity tolerance and increases productivity of peanut through modulating multiple physiological processes [0.03%]
石墨烯氧化物种子处理通过调节多种生理过程提高盐渍条件下花生的耐盐性和产量潜力
Ning Yan,Junfeng Cao,Jie Wang et al.
Ning Yan et al.
Graphene oxide (GO), beyond its specialized industrial applications, is rapidly gaining prominence as a nanomaterial for modern agriculture. However, its specific effects on seed priming for salinity tolerance and yield formation in crops r...