Potentiating dual-directional immunometabolic regulation with nanomedicine to enhance anti-tumor immunotherapy following incomplete photothermal ablation [0.03%]
利用纳米药物增强不完全光热消融后的抗肿瘤免疫治疗以调控双向免疫代谢反应
Qinqin Jiang,Bin Qiao,Jun Zheng et al.
Qinqin Jiang et al.
Photothermal therapy (PTT) is a promising cancer treatment method due to its ability to induce tumor-specific T cell responses and enhance therapeutic outcomes. However, incomplete PTT can leave residual tumors that often lead to new metast...
Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury [0.03%]
基于组学分析的巨噬细胞模拟纳米颗粒靶向功能外泌体微小RNA可缓解脓毒症引起的急性肺损伤
Guozhen Wang,Xiaoxin Ma,Weichang Huang et al.
Guozhen Wang et al.
Patients who suffer from sepsis typically experience acute lung injury (ALI). Extracellular vesicles (EVs) contain miRNAs, which are potentially involved in ALI. However, strategies to screen more effective EV-miRNAs as therapeutic targets ...
Nanoscale insights into hematology: super-resolved imaging on blood cell structure, function, and pathology [0.03%]
纳米血细胞结构、功能和病理学的超分辨成像研究
Jinghan Liu,Yuping Yolanda Tan,Wen Zheng et al.
Jinghan Liu et al.
Fluorescence nanoscopy, also known as super-resolution microscopy, has transcended the conventional resolution barriers and enabled visualization of biological samples at nanometric resolutions. A series of super-resolution techniques have ...
Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy [0.03%]
冷暴露引起的血小板外泌体通过抑制自噬减少骨量
Li-Min Lei,Fu-Xing-Zi Li,Xiao Lin et al.
Li-Min Lei et al.
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure to cold temperature (CT) decre...
Sonodynamic and sonomechanical effect on cellular stemness and extracellular physicochemical environment to potentiate chemotherapy [0.03%]
声动力和声机械效应调节细胞干性和微环境以增敏化疗抵抗干细胞的能力
Danli Sheng,Tianzhi Liu,Lang Qian et al.
Danli Sheng et al.
Background: Hypoxia-activated prodrug (HAP) is a promising candidate for highly tumor-specific chemotherapy. However, the oxygenation heterogeneity and dense extracellular matrix (ECM) of tumor, as well as the potential r...
Cargo-eliminated osteosarcoma-derived small extracellular vesicles mediating competitive cellular uptake for inhibiting pulmonary metastasis of osteosarcoma [0.03%]
无载荷骨肉瘤源小细胞外囊泡介导竞争性摄取抑制肺转移瘤生长
Shanyi Lin,Longqiang Shu,Yuhang Guo et al.
Shanyi Lin et al.
Osteosarcoma (OS) derived small extracellular vesicles (OS-sEVs) have been shown to induce the formation of cancer-associated fibroblasts (CAFs), characterized by elevated pro-inflammatory factor expression and enhanced migratory and contra...
A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy [0.03%]
牙周炎治疗新方向——基于生物材料的巨噬细胞免疫疗法
Shumin Peng,Haojie Fu,Rui Li et al.
Shumin Peng et al.
Periodontitis is a chronic inflammation caused by a bacterial infection and is intimately associated with an overactive immune response. Biomaterials are being utilized more frequently in periodontal therapy due to their designability and u...
Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform [0.03%]
一种多功能的抗氧及神经再生纳米平台修复脊髓损伤
Heng Zhou,Ziwei Li,Shuili Jing et al.
Heng Zhou et al.
Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of the cascade reaction, the effect of excessive reactive oxygen species (ROS) in the early and middle stages of SCI severely damage ne...
Multifunctional nano-in-micro delivery systems for targeted therapy in fundus neovascularization diseases [0.03%]
治疗视网膜新生血管疾病的纳米包裹微载体多功能靶向给药系统
Xin Liu,Keke Huang,Fuxiao Zhang et al.
Xin Liu et al.
Fundus neovascularization diseases are a series of blinding eye diseases that seriously impair vision worldwide. Currently, the means of treating these diseases in clinical practice are continuously evolving and have rapidly revolutionized ...
Laser-activated perfluorocarbon nanodroplets for intracerebral delivery and imaging via blood-brain barrier opening and contrast-enhanced imaging [0.03%]
用于血脑屏障开启和对比增强成像的激光激活全氟碳纳米液滴及输送和成像技术
Kristina A Hallam,Robert J Nikolai,Anamik Jhunjhunwala et al.
Kristina A Hallam et al.
Background: Ultrasound and photoacoustic (US/PA) imaging is a promising tool for in vivo visualization and assessment of drug delivery. However, the acoustic properties of the skull limit the practical application of US/P...