A novel multifunctional nanocomposite hydrogel orchestrates the macrophage reprogramming-osteogenesis crosstalk to boost bone defect repair [0.03%]
一种新型多功能纳米复合水凝胶可调节巨噬细胞重编-骨发生交叉对话以促进骨缺损修复
Ying Wang,Yedan Chen,Tao Zhou et al.
Ying Wang et al.
Repairing bone defects is a complex cascade reaction process, as immune system regulation, vascular growth, and osteogenic differentiation are essential. Thus, developing a tissue-engineered biomaterial that caters to the complex healing pr...
Inflammation-targeted delivery of Urolithin A mitigates chemical- and immune checkpoint inhibitor-induced colitis [0.03%]
靶向递送备孕期孕妇补充叶酸与子代儿童期哮喘的关系：基于父母的队列研究
Sweta Ghosh,Rajbir Singh,Tanu Jain Goap et al.
Sweta Ghosh et al.
Inflammatory bowel disease (IBD) treatment often involves systemic administration of anti-inflammatory drugs or biologics such as anti-TNF-α antibodies. However, current drug therapies suffer from limited efficacy due to unresponsiveness a...
Reduced graphene oxide loaded with tetrahedral framework nucleic acids for combating orthodontically induced root resorption [0.03%]
四面体框架核酸负载还原氧化石墨烯结合牙齿矫正引起牙根吸收
Wenxiu Yuan,Maotuan Huang,Wenqian Chen et al.
Wenxiu Yuan et al.
Root resorption occurs outside the root or within the root canal. Regardless of its region, root resorption is irreversible and in severe cases, may even cause tooth loss. Clinically, the external surface root resorption is usually a side e...
Preferential activation of type I interferon-mediated antitumor inflammatory signaling by CuS/MnO2/diAMP nanoparticles enhances anti-PD-1 therapy for sporadic colorectal cancer [0.03%]
CuS/MnO2/二腺苷5′-甲基焦磷酸纳米颗粒优先激活I型干扰素介导的抗肿瘤炎症信号轴，增强抗PD-1疗法治疗偶发性结直肠癌的功效
Jinrong Peng,Qian Yang,Rong Lei et al.
Jinrong Peng et al.
Converting the "cold" tumor microenvironment (TME) to a "hot" milieu has become the prevailing approach for enhancing the response of immune-excluded/immunosuppressed colorectal cancer (CRC) patients to immune checkpoint blockade (ICB) ther...
Correction: Conformal immunomodulatory hydrogels for the treatment of otitis media [0.03%]
纠正：用于治疗中耳炎的共形免疫调节水凝胶
Yuefan Jin,Yueyi Shang,Cuiping Wu et al.
Yuefan Jin et al.
Published Erratum
Journal of nanobiotechnology. 2024 Nov 11;22(1):695. DOI:10.1186/s12951-024-02959-7 2024
Living photosynthetic microneedle patches for in situ oxygenation and postsurgical melanoma therapy [0.03%]
用于原位供氧和术后黑色素瘤治疗的活光合作用微针贴片
Jinxuan Jia,Xuhong Guo,Yuwei Wang et al.
Jinxuan Jia et al.
Surgical excision remains the principal treatment for melanoma, while tumor recurrence and delayed wound healing often occur due to the residual tumor cells and hypoxic microenvironment in the postoperative skin wounds. Herein, we present a...
Probiotic-derived extracellular vesicles alleviate AFB1-induced intestinal injury by modulating the gut microbiota and AHR activation [0.03%]
益生菌源性细胞外囊泡通过调节肠道微生物群和AHR活化缓解黄曲霉毒素B1致肠损伤
Jinyan Li,Mengdie Shi,Yubo Wang et al.
Jinyan Li et al.
Background: Aflatoxin B1 (AFB1) is a mycotoxin that widely found in the environment and mouldy foods. AFB1 initially targets the intestine, and AFB1-induced intestinal injury cannot be ignored. Lactobacillus amylovorus (L...
GelMA hydrogels reinforced by PCL@GelMA nanofibers and bioactive glass induce bone regeneration in critical size cranial defects [0.03%]
聚己内酯@明胶美徳海绵纳米纤维和生物活性玻璃增强的明胶美德海绵水凝胶促进颅骨缺损修复
Chenghao Yu,Jinli Chen,Tianrui Wang et al.
Chenghao Yu et al.
Background: The process of bone healing is complex and involves the participation of osteogenic stem cells, extracellular matrix, and angiogenesis. The advancement of bone regeneration materials provides a promising oppor...
Silver nanoparticle induced immunogenic cell death can improve immunotherapy [0.03%]
银纳米颗粒诱导的免疫原性细胞死亡可以改善免疫治疗
Ara Sargsian,Xanthippi Koutsoumpou,Hermon Girmatsion et al.
Ara Sargsian et al.
Cancer immunotherapy is often hindered by an immunosuppressive tumor microenvironment (TME). Various strategies are being evaluated to shift the TME from an immunologically 'cold' to 'hot' tumor and hereby improve current immune checkpoint ...
Nanocarriers for intracellular delivery of proteins in biomedical applications: strategies and recent advances [0.03%]
生物医学应用中的蛋白类药物细胞内递送纳米载体：策略与最新研究进展
Chuanda Zhu,Jing Mu,Ling Liang
Chuanda Zhu
Protein drugs are of great importance in maintaining the normal functioning of living organisms. Indeed, they have been instrumental in combating tumors and genetic diseases for decades. Among these pharmaceutical agents, those that target ...