Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency [0.03%]
凋亡小体通过恢复miR-145a-5p缺陷来挽救受损间充质干细胞及其治疗骨质疏松症的潜力
Rong Zhang,Xiaodan Mu,Dawei Liu et al.
Rong Zhang et al.
Apoptotic vesicles (apoVs) play a vital role in various physiological and pathological conditions. However, we have yet to fully understand their precise biological effects in rescuing impaired mesenchymal stem cells (MSCs). Here, we proved...
A multifunctional composite scaffold responds to microenvironment and guides osteogenesis for the repair of infected bone defects [0.03%]
一种多功能复合支架响应微环境并引导成骨修复感染性骨缺损
Jiajia Sun,Haidi Zhu,Huan Wang et al.
Jiajia Sun et al.
Treating bone defect concomitant with microbial infection poses a formidable clinical challenge. Addressing this dilemma necessitates the implementation of biomaterials exhibiting dual capabilities in anti-bacteria and bone regeneration. Of...
Multifunctional carbomer based ferulic acid hydrogel promotes wound healing in radiation-induced skin injury by inactivating NLRP3 inflammasome [0.03%]
基于卡波姆的富马酸水凝胶通过灭活NLRP3炎性小体促进放射引起的皮肤损伤愈合
Congshu Huang,Chaoji Huangfu,Zhijie Bai et al.
Congshu Huang et al.
Background: Radiation-induced skin injury is a significant adverse reaction to radiotherapy. However, there is a lack of effective prevention and treatment methods for this complication. Ferulic acid (FA) has been identif...
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization [0.03%]
通过调节巨噬细胞极化治疗类风湿性关节炎的巨噬细胞膜伪装仿生纳米粒子
Renpeng Zhou,Song Xue,Yuanzhi Cheng et al.
Renpeng Zhou et al.
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic joint inflammation and cartilage damage. Current therapeutic strategies often result in side effects, necessitating the development of targeted and safe...
A new strategy of using low-dose caffeic acid carbon nanodots for high resistance to poorly differentiated human papillary thyroid cancer [0.03%]
一种低剂量咖啡酸碳点用于治疗分化不良的人乳头状甲状腺癌的新策略
Jingwei Xin,Meiwei Song,Xiangling Liu et al.
Jingwei Xin et al.
Thyroid cancer is one of the most common endocrine malignancies in clinical practice. Traditional surgery and radioactive iodine ablation have poor treatment results for poorly differentiated thyroid cancer, and there is a risk of metastasi...
Harnessing the nutriceutics in early-stage breast cancer: mechanisms, combinational therapy, and drug delivery [0.03%]
营养素在早期内乳腺癌中的作用：机制、联合治疗和药物递送
Pavithra Pradeep Prabhu,Barsha Mohanty,Cynthia Lizzie Lobo et al.
Pavithra Pradeep Prabhu et al.
Background: Breast cancer (BC) is a significant health challenge, ranking as the second leading cause of cancer-related death and the primary cause of mortality among women aged 45 to 55. Early detection is crucial for op...
Brain-on-a-chip: an emerging platform for studying the nanotechnology-biology interface for neurodegenerative disorders [0.03%]
神经系统变性疾病研究中新兴的纳米技术-生物学界面的研究平台：芯片式脑组织模型
Raquel O Rodrigues,Su-Ryon Shin,Manuel Bañobre-López
Raquel O Rodrigues
Neurological disorders have for a long time been a global challenge dismissed by drug companies, especially due to the low efficiency of most therapeutic compounds to cross the brain capillary wall, that forms the blood-brain barrier (BBB) ...
Correction: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy [0.03%]
纠正：冷暴露诱导的血浆外泌体通过抑制自噬减少骨量
Li-Min Lei,Fu-Xing-Zi Li,Xiao Lin et al.
Li-Min Lei et al.
Published Erratum
Journal of nanobiotechnology. 2024 Sep 18;22(1):572. DOI:10.1186/s12951-024-02834-5 2024
New insights into allergic rhinitis treatment: MSC nanovesicles targeting dendritic cells [0.03%]
过敏性鼻炎治疗新见解：靶向树突状细胞的间充质干细胞纳米囊泡
Jianyu Liu,Meiqun Wang,Xiaoyan Tian et al.
Jianyu Liu et al.
Allergic rhinitis (AR) is a condition with limited treatment options. This study investigates the potential use of mesenchymal stem cell (MSC) nanovesicles as a novel therapy for AR. Specifically, the study explores the underlying mechanism...
Thermosensitive hydrogel as a sustained release carrier for mesenchymal stem cell-derived extracellular vesicles in the treatment of intrauterine adhesion [0.03%]
温敏水凝胶作为间充质干细胞源外泌体治疗宫腔粘连的缓释载体
Shujun Yu,Xinru Zhang,Wenwen Li et al.
Shujun Yu et al.
Intrauterine adhesion (IUA), a prevalent etiology of female infertility, is attributed to endometrial damage. However, conventional therapeutic interventions for IUA are plagued by high recurrence rates. Human umbilical cord mesenchymal ste...