Jiasheng Yuan,Huquan Zhu,Shixinyi Li et al.
Jiasheng Yuan et al.
Background: The urgent need for affordable and rapid detection methodologies for foodborne pathogens, particularly Escherichia coli (E. coli), highlights the importance of developing efficient and widely accessible diagno...
Modification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation [0.03%]
通过同轴静电纺纳米纤维膜对经阴道聚丙烯网片进行改性以减轻植入后的手术并发症
Tao Guo,Xuechun Hu,Zhe Du et al.
Tao Guo et al.
Background: Surgeries for treating pelvic organ prolapse involving the utilization of synthetic mesh have been associated with complications such as mesh erosion, postoperative pain, and dyspareunia. This work aimed to re...
Integrated triple signal amplification strategy for ultrasensitive electrochemical detection of gastric cancer-related microRNA utilizing MoS2-based nanozyme, hybridization chain reaction, and horseradish peroxidase [0.03%]
利用二硫化钼纳米酶、杂交链反应和辣根过氧化物酶的一体化三信号放大策略用于胃癌相关microRNA的超灵敏电化学检测
Jianfeng Ma,Qunyan Yao,Suo Lv et al.
Jianfeng Ma et al.
Early diagnosis and treatment of gastric cancer (GC) play a vital role in improving efficacy, reducing mortality and prolonging patients' lives. Given the importance of early detection of gastric cancer, an electrochemical biosensor was dev...
NIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy [0.03%]
基于负载小分子光敏剂的纳米粒子的近红外激活一氧化氮发生器用于协同光动力/气体治疗
Lili Fu,Yan Huang,Xin Shan et al.
Lili Fu et al.
Background: Therapeutic approaches that combine conventional photodynamic therapy (PDT) with gas therapy (GT) to sensitize PDT are an attractive strategy, but the molecular structure design of the complex lacks effective ...
Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3 [0.03%]
纳米放疗增强剂NBTXR3可放大质子治疗较光子治疗所达到的更强的抗肿瘤免疫反应
Yun Hu,Sébastien Paris,Narayan Sahoo et al.
Yun Hu et al.
Recent findings suggest that immunoradiotherapy (IRT), combining photon radiotherapy (XRT) or proton radiotherapy (PRT) with immune checkpoint blockade, can enhance systemic tumor control. However, the comparative efficacy of XRT and PRT in...
Magnesium metal-organic framework microneedles loaded with curcumin for accelerating oral ulcer healing [0.03%]
负载有姜黄素的镁金属有机骨架微针促进口腔溃疡修复
Junhui Liu,Zhipeng Zhang,Xiufei Lin et al.
Junhui Liu et al.
Oral ulcers are a common oral mucosal disease that seriously affect the quality of life. Traditional drug treatments have shown unsatisfactory efficacy and potential adverse reactions. In this study, curcumin-loaded multifunctional magnesiu...
A metal-organic nanoframework for efficient colorectal cancer immunotherapy by the cGAS-STING pathway activation and immune checkpoint blockade [0.03%]
一种金属有机纳米框架通过活化cGAS-STING途径和免疫检查点阻断进行高效的结直肠癌免疫治疗
Xiaodian Zhang,Hailong Tian,Yang Chen et al.
Xiaodian Zhang et al.
Immunotherapy has shown marked progress in promoting systemic anti-colorectal cancer (CRC) clinical effects. For further effectively sensitizing CRC to immunotherapy, we have engineered a pH-sensitive zeolitic imidazolate framework-8 (CS/NP...
Enzyme-armed nanocleaner provides superior detoxification against organophosphorus compounds via a dual-action mechanism [0.03%]
双管齐下机制使纳米清洁剂在酶的作用下高效降解有机磷化合物中毒素
Kang Qin,Fei Meng,Dianpeng Han et al.
Kang Qin et al.
By inhibiting acetylcholinesterase (AChE) activity, organophosphate compounds (OPs) can quickly cause severe injury to the nervous system and death, making it extremely difficult to rescue victims after OP exposure. However, it is quite cha...
Multiparametric profiling of HER2-enriched extracellular vesicles in breast cancer using Single Extracellular VEsicle Nanoscopy [0.03%]
基于单个细胞外囊泡纳米显微镜的乳腺癌HER2富集型细胞外囊泡多参数谱分析
Nan Jiang,Andras Saftics,Eugenia Romano et al.
Nan Jiang et al.
Background: Patients with HER2-positive breast cancer can significantly benefit from HER2-directed therapy - such as the monoclonal antibody trastuzumab. However, some patients can develop therapy resistance or change HER...
Lymph node metastasis diagnosis of postoperative OSCC patients by analyzing extracellular vesicles in drainage fluid based on microfluidic isolation [0.03%]
基于微流控隔离技术分析引流液中细胞外囊泡诊断术后OSCC患者淋巴结转移性病变
Zi-Zhan Li,Ze-Min Cai,Wen-Tao Zhu et al.
Zi-Zhan Li et al.
Lymph node metastasis (LNM) is a typical marker in oral squamous cell carcinoma (OSCC) indicating poor prognosis. Pathological examination by artificial image acquisition and analysis, as the main diagnostic method for LNM, often takes a we...