Microenvironment-optimized gastrodin-functionalized scaffolds orchestrate asymmetric division of recruited stem cells in endogenous bone regeneration [0.03%]
微环境优化的石菖蒲素功能化支架调控内源性募集干细胞的不对称分裂以促进骨再生
Shilin Pan,Yao Li,Lu Wang et al.
Shilin Pan et al.
The regeneration of osteoporotic bone defects remains challenging as the critical stem cell function is impaired by inflammatory microenvironment. Synthetic materials that intrinsically direct osteo-differentiation versus self-renewal of re...
Endothelial cell-derived exosomes trigger a positive feedback loop in osteogenesis-angiogenesis coupling via up-regulating zinc finger and BTB domain containing 16 in bone marrow mesenchymal stem cell [0.03%]
内皮细胞来源的外泌体通过上调骨髓间充质干细胞ZBTB16在成骨-血管化偶联中触发正反馈调节机制
Lu Liu,Nan Zhou,Songning Fu et al.
Lu Liu et al.
The close spatial and temporal connection between osteogenesis and angiogenesis around type H vasculature is referred as "osteogenesis-angiogenesis coupling", which is one of the basic mechanisms of osteogenesis. Endothelial cells (ECs), bo...
Physical, biochemical, and biological characterization of olive-derived lipid nanovesicles for drug delivery applications [0.03%]
基于橄榄提取物的脂质纳米载体的物理、生化及生物学特性研究及其在药物递送领域的应用价值探讨
Zhu Zhao,Jerome Lacombe,Laurianne Simon et al.
Zhu Zhao et al.
Extracellular vesicles (EVs) have shown great promise as drug delivery system (DDS). However, their complex and costly production limit their development for clinical use. Interestingly, the plant kingdom can also produce EV-like nanovesicl...
Fluorescence sensor array for highly sensitive pattern recognition of biothiols in food based on tricolor upconversion luminescence metal-organic frameworks [0.03%]
一种基于三色上转换发光金属有机骨架的食品生物硫醇高灵敏模式识别荧光传感器阵列
Mingyuan Yin,Dongfang Qiu,Meiqi Wang et al.
Mingyuan Yin et al.
Fluorescence nanomaterial sensors have exhibited excellent application potential in biothiols analyses. The fluorescence sensor arrays constructed from upconversion luminescence metal-organic frameworks nanocomposites (LMOFs) can provide im...
Exploring the anti-inflammatory effects of curcumin encapsulated within ferritin nanocages: a comprehensive in vivo and in vitro study in Alzheimer's disease [0.03%]
体内体外全面研究：利用铁蛋白纳米颗粒递送姜黄素探究其抗炎效应在阿尔茨海默病中的作用
Carlo Morasso,Marta Truffi,Veronica Tinelli et al.
Carlo Morasso et al.
Background: The global demographic shift towards an aging population is generating a rise in neurodegenerative conditions, with Alzheimer's disease (AD) as the most prominent problem. In this landscape, the use of natural...
Lingli Wang,Jiawu Wan,Wenna He et al.
Lingli Wang et al.
Messenger RNA (mRNA) vaccines are a key technology in combating existing and emerging infectious diseases. However, improving the immunogenicity and durability of mRNA vaccines remains a challenge. To elicit optimal immune responses, integr...
Precision management of Fusarium fujikuroi in rice through seed coating with an enhanced nanopesticide using a tannic acid-ZnII formulation [0.03%]
一种使用单宁酸-锌(ii)制剂的改进型纳米杀菌剂包衣稻种精准防控枯萎病菌侵染水稻试验
Qizhen Zhang,Xin Shi,Tuqiang Gao et al.
Qizhen Zhang et al.
Seed coating with fungicides is a common practice in controlling seed-borne diseases, but conventional methods often result in high toxicity to plants and soil. In this study, a nanoparticle formulation was successfully developed using the ...
Xiaohan Ma,Yaxin Tian,Ren Yang et al.
Xiaohan Ma et al.
Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities in diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of na...
The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine [0.03%]
纳米医学中患者特异性变量在蛋白质冠形成和治疗效果中的作用
Ethan P Cisneros,Brinkley A Morse,Ani Savk et al.
Ethan P Cisneros et al.
Despite their potential, the adoption of nanotechnology in therapeutics remains limited, with only around eighty nanomedicines approved in the past 30 years. This disparity is partly due to the "one-size-fits-all" approach in medical design...
Enhanced antiviral defense against begomoviral infection in Nicotiana benthamiana through strategic utilization of fluorescent carbon quantum dots to activate plant immunity [0.03%]
通过战略性利用荧光碳量子点激活植物免疫来增强拟南芥对双生病毒感染的抗病毒防御机制
Tahir Farooq,Muhammad Dilshad Hussain,Yuan Wang et al.
Tahir Farooq et al.
Background: Owing to their unique physiochemical properties, low toxicity, antipathogenic effects and tunability, fluorescent carbon quantum dots (CQDs) represent a new generation of carbon-based nanomaterials. Despite th...