Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury [0.03%]
负载miR-146a的IMTP修饰乳外泌体靶向递送通过抑制NF-κB信号途径发挥心肌缺血再灌注损伤的心脏保护作用
Wan-Ting Meng,Jing Zhu,Ya-Chao Wang et al.
Wan-Ting Meng et al.
Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium. This phenomenon is known as myocardial ischemia-reperfusion injury ...
Xinyu Zhao,Zenghong Chen,Shuo Zhang et al.
Xinyu Zhao et al.
Metal-organic frameworks (MOFs) are metal-organic skeleton compounds composed of self-assembled metal ions or clusters and organic ligands. MOF materials often have porous structures, high specific surface areas, uniform and adjustable pore...
Cardiac-derived extracellular vesicles improve mitochondrial function to protect the heart against ischemia/reperfusion injury by delivering ATP5a1 [0.03%]
心脏来源的细胞外囊泡通过递送ATP5a1改善线粒体功能以保护心脏免受缺血再灌注损伤的影响
Xuan Liu,Qingshu Meng,Shanshan Shi et al.
Xuan Liu et al.
Background: Numerous studies have confirmed the involvement of extracellular vesicles (EVs) in various physiological processes, including cellular death and tissue damage. Recently, we reported that EVs derived from ische...
Recent advances in gene delivery nanoplatforms based on spherical nucleic acids [0.03%]
基于球形核酸的基因递送纳米平台最新研究进展
Nazila Valatabar,Fatemeh Oroojalian,Mina Kazemzadeh et al.
Nazila Valatabar et al.
Gene therapy is a therapeutic option for mitigating diseases that do not respond well to pharmacological therapy. This type of therapy allows for correcting altered and defective genes by transferring nucleic acids to target cells. Notably,...
Melt-electrowriting-enabled anisotropic scaffolds loaded with valve interstitial cells for heart valve tissue Engineering [0.03%]
基于熔融电写的载心阀间质细胞各向异性支架用于心脏瓣膜组织工程
Chao Xu,Kun Yang,Yin Xu et al.
Chao Xu et al.
Tissue engineered heart valves (TEHVs) demonstrates the potential for tissue growth and remodel, offering particular benefit for pediatric patients. A significant challenge in designing functional TEHV lies in replicating the anisotropic me...
Muhammad Babar Khawar,Ali Afzal,Yue Si et al.
Muhammad Babar Khawar et al.
Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing challenges like immunogenicity, reduced toxicity, and improved safet...
Photosynthetic bacteria-based whole-cell inorganic-biohybrid system for multimodal enhanced tumor radiotherapy [0.03%]
一种基于光合细菌的无机-生物混合系统用于多模态肿瘤增强放疗
Shiyuan Hua,Jun Zhao,Lin Li et al.
Shiyuan Hua et al.
The whole-cell inorganic-biohybrid systems show special functions and wide potential in biomedical application owing to the exceptional interactions between microbes and inorganic materials. However, the hybrid systems are still in stage of...
Controlled synthesized of ternary Cu-Co-Ni-S sulfides nanoporous network structure on carbon fiber paper: a superior catalytic electrode for highly-sensitive glucose sensing [0.03%]
在碳纤维纸上合成三元Cu-Co-Ni-S硫化物纳米多孔网络结构：用于高灵敏葡萄糖传感的优异电催化剂
Yuanyuan Li,Yi Duan,Jiangtao Lin et al.
Yuanyuan Li et al.
Background: Efficient monitoring of glucose concentration in the human body necessitates the utilization of electrochemically active sensing materials in nonenzymatic glucose sensors. However, prevailing limitations such ...
Activation of the Wnt/β-catenin signalling pathway enhances exosome production by hucMSCs and improves their capability to promote diabetic wound healing [0.03%]
Wnt/β-catenin信号通路的激活可增强人脐带间充质干细胞源外泌体的生成并提高其促进糖尿病创面修复的功能
Liming Wang,Jun Chen,Jia Song et al.
Liming Wang et al.
Background: The use of stem cell-derived exosomes (Exos) as therapeutic vehicles is receiving increasing attention. Exosome administration has several advantages over cell transplantation, thus making exosomes promising c...
Advanced gene nanocarriers/scaffolds in nonviral-mediated delivery system for tissue regeneration and repair [0.03%]
高级基因纳米载体/支架在非病毒介导的递送系统中的应用促进组织再生和修复
Wanheng Zhang,Yan Hou,Shiyi Yin et al.
Wanheng Zhang et al.
Tissue regeneration technology has been rapidly developed and widely applied in tissue engineering and repair. Compared with traditional approaches like surgical treatment, the rising gene therapy is able to have a durable effect on tissue ...