Double-camouflaged tellurium nanoparticles for enhanced photothermal immunotherapy of tumor [0.03%]
用于增强肿瘤光热免疫治疗的双重伪装的碲纳米粒子
Chaoqing Li,Luyao Yang,Bin Zhang et al.
Chaoqing Li et al.
The photothermal conversion properties of tellurium (Te) nanoparticles have been extensively investigated, rendering them a promising candidate for tumor photothermal therapy. However, there is still room for improvement in the development ...
Nanomaterial-mediated host directed therapy of tuberculosis by manipulating macrophage autophagy [0.03%]
纳米材料介导的宿主导向结核病治疗及其对巨噬细胞自噬的调控作用研究
Yilin Liu,Jiajun Wang,Jiayi Yang et al.
Yilin Liu et al.
Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a major public health issue worldwide. Mtb has developed complicated strategies to inhibit the immunological clearance of host cells, which significantly prom...
Shiqi Han,Jianhua Zou,Fan Xiao et al.
Shiqi Han et al.
Ferroptosis, distinct from apoptosis, necrosis, and autophagy, is a unique type of cell death driven by iron-dependent phospholipid peroxidation. Since ferroptosis was defined in 2012, it has received widespread attention from researchers w...
Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice [0.03%]
口服给药飞燕草衍生的携带CX5461的类外泌体纳米囊泡可改善小鼠DSS诱导结肠炎
Manqi Zhang,Xichao Xu,Liqian Su et al.
Manqi Zhang et al.
Ulcerative colitis (UC) belongs to chronic inflammatory disease with a relapsing characterization. Conventional oral drugs of UC are restricted in clinical by premature degradation in the gastrointestinal tract, modest efficacy, and adverse...
Ultrasound-responsive nanocarriers with siRNA and Fe3O4 regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy [0.03%]
负载siRNA和Fe3O4的响应型纳米载体调节巨噬细胞极化及吞噬作用以增强非小细胞肺癌免疫治疗
Ming Li,Yuanyuan Li,Jun Zheng et al.
Ming Li et al.
The immunosuppressive tumor microenvironment (TME) significantly inhibits the effective anti-tumor immune response, greatly affecting the efficacy of immunotherapy. Most tumor-associated macrophages (TAMs) belong to the M2 phenotype, which ...
Biomimetic nanocarriers in cancer therapy: based on intercellular and cell-tumor microenvironment communication [0.03%]
仿生纳米载体在癌症治疗中的应用基于细胞间及细胞与肿瘤微环境的交流沟通
He Mengyuan,Li Aixue,Gu Yongwei et al.
He Mengyuan et al.
Inspired by the concept of "natural camouflage," biomimetic drug delivery systems have emerged to address the limitations of traditional synthetic nanocarriers, such as poor targeting, susceptibility to identification and clearance, inadequ...
Co-freezing localized CRISPR-Cas12a system enables rapid and sensitive nucleic acid analysis [0.03%]
共冷冻局部化CRISPR-Cas12a系统可实现快速灵敏的核酸检测
Lifeng Zhang,Shihua Luo,Wenbin Li et al.
Lifeng Zhang et al.
Rapid and sensitive nucleic acid detection is vital in disease diagnosis and therapeutic assessment. Herein, we propose a co-freezing localized CRISPR-Cas12a (CL-Cas12a) strategy for sensitive nucleic acid detection. The CL-Cas12a was obtai...
Personalized mRNA vaccines in glioblastoma therapy: from rational design to clinical trials [0.03%]
个性化mRNA疫苗在胶质母细胞瘤治疗中的应用：从理性设计到临床试验
Iman Karimi-Sani,Zahra Molavi,Samaneh Naderi et al.
Iman Karimi-Sani et al.
Glioblastomas (GBMs) are the most common and aggressive malignant brain tumors, presenting significant challenges for treatment due to their invasive nature and localization in critical brain regions. Standard treatment includes surgical re...
3D-printing hydrogel programmed released exosomes to restore aortic medial degeneration through inhibiting VSMC ferroptosis in aortic dissection [0.03%]
用于抑制主动脉夹层平滑肌细胞铁死亡从而通过程序化释放外泌体来修复主动脉中膜退行性变的3D打印水凝胶
Weitie Wang,Qing Liu,Qiwei Yang et al.
Weitie Wang et al.
Aortic dissection (AD) is a devastating disease with a high mortality rate. Exosomes derived from mesenchymal stem cells (exo-MSCs) offer a promising strategy to restore aortic medial degeneration and combat ferroptosis in AD. However, thei...
Targeted blood-brain barrier penetration and precise imaging of infiltrative glioblastoma margins using hybrid cell membrane-coated ICG liposomes [0.03%]
利用混合细胞膜包被的吲哚菁绿脂质体实现浸润性胶质母细胞瘤边界的靶向血脑屏障递送与精准成像
Ping Liu,Siyi Lan,Duyang Gao et al.
Ping Liu et al.
Surgical resection remains the primary treatment modality for glioblastoma (GBM); however, the infiltrative nature of GBM margins complicates achieving complete tumor removal. Additionally, the blood-brain barrier (BBB) poses a formidable c...