Time-series metabolomic analysis revealed altered metabolism of cynomolgus monkeys after injecting exosomes [0.03%]
时间序列代谢组分析揭示了注射外泌体后的食蟹猴代谢改变过程
Xinmei Hu,Cancan Wang,Yu Xiao et al.
Xinmei Hu et al.
Background: Recent years, exosomes have been increasing used to treat diseases, but there is little research on how exosomes affect the metabolism of the body after entering. Therefore, in this study, we discussed the cha...
Polydopamine(PDA)-coated diselenide-bridged mesoporous silica-based nanoplatform for neuroprotection by reducing oxidative stress and targeting neuroinflammation in intracerebral hemorrhage [0.03%]
聚多巴胺（PDA）涂层二硒代桥连介孔硅基纳米平台通过降低氧化应激和靶向神经炎症来保护颅内出血的神经元
Fangfang Zhou,Yongju He,Meiru Zhang et al.
Fangfang Zhou et al.
Oxidative stress (OS) and neuroinflammation are critical pathological processes in secondary brain injury (SBI) after intracerebral hemorrhage(ICH), and their intimate interactions initiate and aggravate brain damage. Thus, targeting oxidat...
Probiotics alleviate chronic ethanol exposure-induced anxiety-like behavior and hippocampal neuroinflammation in male mice through gut microbiota-derived extracellular vesicles [0.03%]
益生菌通过肠道微生物群衍生的细胞外囊泡缓解慢性酒精暴露引起的雄性小鼠类似焦虑的行为和海马神经炎症
Jiaxin Pei,Chaoxu Zhang,Qian Zhang et al.
Jiaxin Pei et al.
Background: Probiotics can colonize both the human and animal bodies and consist of active microorganisms that are beneficial to health. The use of probiotics has been shown to alleviate certain neurological diseases and ...
Radionuclide-labelled nanoparticles for cancer combination therapy: a review [0.03%]
放射核素标记的纳米颗粒在癌症联合治疗中的应用：综述
Na Sun,Tao Wang,Song Zhang
Na Sun
Radionuclide therapy (RT) is widely used to advanced local cancers. However, its therapeutic efficacy is limited to the radiation resistance of cancer cells. Combination therapy aims to circumvent tumor resistance, and the combination of RT...
ROS-responsive nanoparticles for bioimaging and treating acute lung injury by releasing dexamethasone and improving alveolar macrophage homeostasis [0.03%]
响应 ROS 的纳米颗粒通过释放地塞米松和改善肺泡巨噬细胞稳态用于生物成像及急性肺损伤治疗
Wenna Fan,Yongyao Tang,Yamin Liu et al.
Wenna Fan et al.
Background: Acute lung injury (ALI) triggers the activation of pulmonary macrophages, which in turn produce excessive amounts of reactive oxygen species (ROS). ...
Three-arm polyrotaxanes with multidirectional molecular motions as the nanocarrier for nitric oxide-enhanced photodynamic therapy against bacterial biofilms in septic arthritis [0.03%]
具有多方向分子运动的三臂聚轮烷作为硝化物增强光动力疗法载体用于败血性关节炎中细菌生物被膜的治疗
Shixin Liu,Yuanfang Jiang,Yu Zhang et al.
Shixin Liu et al.
Bacterial biofilms are one of the major contributors to the refractoriness of septic arthritis. Although nitric oxide (NO)-enhanced photodynamic (PDT) therapy has been involved in biofilm eradication, the anti-biofilm efficacy is usually hi...
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing [0.03%]
基于高通量筛选的多功能天然聚酚纳米囊泡的设计以加速糖尿病伤口愈合
Xiaoying Zhao,Shenkai Su,Chenyu Wu et al.
Xiaoying Zhao et al.
Oxidative stress is a major pathological factor that impedes the diabetic wound healing process. Procyanidins (PC) form nanoparticle-vesicles (PPNs) through hydrogen bonding and exhibit good drug delivery capability; however, their applicat...
An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors [0.03%]
金属离子与天然产物的偶遇：基于天然产物配位修饰金属离子的肿瘤诊疗研究
Xinyue Liu,Suyi Liu,Xingyue Jin et al.
Xinyue Liu et al.
Natural products-coordinated metal ions to form the nanomedicines are in the spotlight for cancer therapy. Some natural products could be coordinated with metal ions forming nanomedicines via simple and green environmental self-assembly, wh...
Microfluidic-engineered Chinese herbal nanocomposite hydrogel microspheres for diabetic wound tissue regeneration [0.03%]
用于糖尿病创面组织再生的微流控工程中药纳米复合水凝胶微球
Peng Guo,Pengkun Lei,Lin Luo et al.
Peng Guo et al.
Microfluidic-engineered hydrogel microspheres have emerged as a promising avenue for advancements in tissue engineering and regenerative medicine, particularly through the precise manipulation of fluids to achieve personalized composite bio...
Fu-Xing-Zi Li,Jun-Jie Liu,Li-Min Lei et al.
Fu-Xing-Zi Li et al.
Cold temperatures have been shown to slow skin wound healing. However, the specific mechanisms underlying cold-induced impairment of wound healing remain unclear. Here, we demonstrate that small extracellular vesicles derived from cold-expo...