From dansyl-modified biofilm disruptors to β-cyclodextrin-optimized multifunctional supramolecular nanovesicles: their improved treatment for plant bacterial diseases [0.03%]
从丹磺酰修饰的生物被膜瓦解剂到β-环糊精优化的多功能超分子纳米囊泡：改善植物细菌病害的治疗方案
Hui-Ling Zhang,Hong-Wei Wang,Jing-Han Yang et al.
Hui-Ling Zhang et al.
Background: Bacterial diseases caused by phytopathogenic Xanthomonas pose a significant threat to global agricultural production, causing substantial economic losses. Biofilm formation by these bacteria enhances their res...
Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease [0.03%]
口服改良型硒化透明质酸纳米凝胶介导的线粒体能量恢复驱动炎症性肠病治疗
Manxiu Huai,Mingliang Pei,Jie Chen et al.
Manxiu Huai et al.
The damnification of mitochondrion is often considered to be an important culprit of inflammatory bowel disease (IBD), however, there are fewer reports of mechanisms of mitochondria-mediated IBD treatment. Therefore, we first proposed to re...
Accurate HER2 determination in breast cancer: a prominent COF-immobilized enzyme-enhanced electrochemical aptasensor employing 4-acetamidophenol as an efficient mediator [0.03%]
一种高效的赫尔普林霉素介导的电化学适配子传感器用于准确测定乳腺癌中的HER2分子
Yue Zhang,Shuyi Chen,Jie Ma et al.
Yue Zhang et al.
An effective strategy for enzyme-enhanced electrochemical detection of human epidermal growth factor receptor 2 (HER2) is proposed for breast cancer diagnosis. This strategy utilizes a three-dimensional mesoporous covalent organic framework...
Albumin-seeking near-infrared-II probe evaluating blood-brain barrier disruption in stroke [0.03%]
一种用于评估中风时血脑屏障破坏的白蛋白寻找近红外Ⅱ探针
Hong-Jing Zhu,Ying-Ying Sun,Yijing Du et al.
Hong-Jing Zhu et al.
Background: Blood-brain barrier (BBB) disruption after stroke is closely associated with brain tissue edema and neuronal injury, which requires accurate assessment. However, there is a lack of appropriate BBB imaging moda...
Biomimetic mesenchymal stem cell membrane-coated nanoparticle delivery of MKP5 inhibits hepatic fibrosis through the IRE/XBP1 pathway [0.03%]
仿生间质干细胞膜包被的纳米颗粒递送MKP5通过IRE/XBP1信号通路抑制肝纤维化
Yafei Tian,Dandan Sun,Na Liu et al.
Yafei Tian et al.
Hepatic fibrosis is a common disease with high morbidity and mortality rates. The complex and poorly understood mechanisms underlying hepatic fibrosis represent a significant challenge for the development of more effective therapeutic strat...
Dendritic mesoporous silica-delivered siRNAs nano insecticides to prevent Sogatella furcifera by inhibiting metabolic detoxification and reproduction [0.03%]
用于抑制代谢解毒和繁殖的树突状介孔二氧化硅递送的siRNA纳米杀虫剂以预防稻飞虱
Changwei Gong,Wei Wang,Yanxin Ma et al.
Changwei Gong et al.
Background: Migratory insect infestation caused by Sogatella furcifera is a serious threat to rice production. The most effective method available for S. furcifera control is intensive insecticide spraying, which cause wi...
Targeting the tumor microenvironment with biomaterials for enhanced immunotherapeutic efficacy [0.03%]
基于生物材料的肿瘤微环境重编程以增强免疫治疗效力
Yekai Feng,Qinglai Tang,Bin Wang et al.
Yekai Feng et al.
The tumor microenvironment (TME) is a complex system characterized by low oxygen, low pH, high pressure, and numerous growth factors and protein hydrolases that regulate a wide range of biological behaviors in the tumor and have a profound ...
Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules [0.03%]
通过柔软的有机硅纳米胶囊实现双模克服物理障碍改善光动力癌症治疗
Wei Lu,Yang Li,Xiaojun Zhang et al.
Wei Lu et al.
Amidst the burgeoning field of cancer nanomedicine, dense extracellular matrices and anomalous vascular structures in the tumor microenvironment (TME) present substantial physical barriers to effective therapeutic delivery. These physical b...
Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model [0.03%]
靶向递送siRNA的脂质体纳米颗粒通过抑制单核细胞和内皮细胞之间的相互作用来抑制病理性瘢痕的形成：基于新型小鼠瘢痕模型的临床前研究
Luyu Li,Yong Wang,Jing Meng et al.
Luyu Li et al.
Background: Pathological scars (PS) are one of the most common complications in patients with trauma and burns, leading to functional impairments and aesthetic concerns. Mechanical tension at injury sites is a crucial fac...
Multifunctional nanocomposites utilizing ruthenium (II) complex/manganese (IV) dioxide nanoparticle for synergistic reinforcing radioimmunotherapy [0.03%]
用于协同增强放射免疫治疗的钌（II）配合物/锰（IV）二氧化纳米粒子多功能纳复合材料
Jian Peng,Dong-Ling Quan,Guang Yang et al.
Jian Peng et al.
Radiotherapy (RT) stands as a frontline treatment modality in clinical breast oncology, yet challenges like ROS reduction, high toxicity, non-selectivity, and hypoxia hinder efficacy. Additionally, RT administered at different doses can ind...