Nebulized milk exosomes loaded with siTGF-β1 ameliorate pulmonary fibrosis by inhibiting EMT pathway and enhancing collagen permeability [0.03%]
载有siTGF-β1的乳糜微粒通过抑制上皮间质转化途径并增强胶原渗透能力来改善肺纤维化
Chong Qiu,Zhenyu Zhao,Chenglin Xu et al.
Chong Qiu et al.
Pulmonary Fibrosis (PF) is a fatal disease in the interstitial lung associated with high mortality, morbidity, and poor prognosis. Transforming growth factor-β1 (TGF-β1) is a fibroblast-activating protein that promotes fibrous diseases. H...
Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair [0.03%]
基于促血管生成和抗氧化的ROS响应型复合水凝胶介导黑色磷纳米片的心肌梗死修复递送研究
Jiahui Zhang,Di Sun,Yishan Guo et al.
Jiahui Zhang et al.
Myocardial infarction (MI) is one of the leading causes of death. This is attributed to the dramatic changes in the myocardial microenvironment post-MI. Therefore, effective intervention in the early stages of MI is significant for inhibiti...
Nanotechnology-empowered combination therapy for rheumatoid arthritis: principles, strategies, and challenges [0.03%]
纳米技术增强的类风湿性关节炎联合治疗：原理、策略与挑战
Shujing Ren,Yuhang Xu,Xingpeng Dong et al.
Shujing Ren et al.
Rheumatoid arthritis (RA) is an autoimmune disease with multifactorial etiology and intricate pathogenesis. In RA, repeated monotherapy is frequently associated with inadequate efficacy, drug resistance, and severe side effects. Therefore, ...
The combination of modified acupuncture needle and melittin hydrogel as a novel therapeutic approach for rheumatoid arthritis treatment [0.03%]
改良 acupuncture 针与蜂毒肽水凝胶联合治疗类风湿性关节炎的新方法
Lisha Liu,Dashi Deng,Chenchen Li et al.
Lisha Liu et al.
Rheumatoid arthritis (RA) involves chronic joint inflammation. Combining acupuncture and medication for RA treatment faces challenges like spatiotemporal variability, limited drug loading in acupuncture needles, and premature or untargeted ...
Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer [0.03%]
负载帕唑帕尼纳米颗粒的金属有机框架体内的抗肿瘤效应与M2型巨噬细胞的关系研究
Zhijie Xu,Zhiyang Zhou,Xiaoxin Yang et al.
Zhijie Xu et al.
Pazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic activities against various human cancers. However, its clinical utility is limited by substantial side effects and therapeutic resistance. We develo...
Acidity-activatable dynamic hybrid nanoplatforms derived from extracellular vesicles of M1 macrophages enhance cancer immunotherapy through synergistic triple immunotherapy [0.03%]
由M1巨噬细胞外泌体衍生的酸激活动态杂化纳米平台通过协同三联免疫疗法增强癌症免疫治疗
Yawen Guo,Tingting Lv,Zijie Li et al.
Yawen Guo et al.
Immunotherapy exhibits considerable promise for sustained tumor reduction. However, current cancer immunotherapy methods elicit limited responses due to the inadequate immunogenicity exhibited by cancer cells. This obstacle may be addressed...
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis [0.03%]
牙髓间充质干细胞衍生的外泌体通过miRNA-197-3p/FOXO3轴抑制蛛网膜下腔出血引起的神经炎症和小胶质细胞pyroptosis
Xin Liang,Yan Miao,Xin Tong et al.
Xin Liang et al.
Background: Subarachnoid hemorrhage (SAH) is a severe stroke subtype that lacks effective treatment. Exosomes derived from human dental pulp stem cells (DPSCs) are a promising acellular therapeutic strategy for neurologic...
MMP-3 mediates copper oxide nanoparticle-induced pulmonary inflammation and fibrosis [0.03%]
铜氧化物纳米粒子通过MMP-3介导诱导肺部炎症和纤维化
Yuanbao Zhang,Zhenyu Zhang,Yiqun Mo et al.
Yuanbao Zhang et al.
Background: The increasing production and usage of copper oxide nanoparticles (Nano-CuO) raise human health concerns. Previous studies have demonstrated that exposure to Nano-CuO could induce lung inflammation, injury, an...
Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges [0.03%]
无机纳米粒子在结直肠癌治疗中的应用：近期进展与挑战
Soumya Narayana,B H Jaswanth Gowda,Umme Hani et al.
Soumya Narayana et al.
Colorectal cancer, the third most prevalent cancer globally, contributes significantly to mortality rates, with over 1.9 million reported cases and nearly 935,000 fatalities annually. Surgical resection is a primary approach for localized c...
Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway [0.03%]
小鼠须毛乳头来源外泌体通过激活Wnt/β-联蛋白信号通路促进损伤部位毛囊再生
Yage Shang,Mengyang Li,Lixia Zhang et al.
Yage Shang et al.
Hair follicle (HF) regeneration during wound healing continues to present a significant clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) hold immense potential for inducing HF neogenesis. However, the accurate role and un...