Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma [0.03%]
通过铜死亡和代谢重编程协同增强低剂量放疗以增敏原位肝癌放射治疗的效果
Ni Shao,Yongqing Yang,Genwen Hu et al.
Ni Shao et al.
Background: Radiotherapy (RT) is a primary clinical approach for cancer treatment, but its efficacy is often hindered by various challenges, especially radiation resistance, which greatly compromises the therapeutic effec...
Single-cell RNA sequencing uncovers heterogenous immune cell responses upon exposure to food additive (E171) titanium dioxide [0.03%]
单细胞RNA测序揭示食品添加剂二氧化钛(E171)暴露后异质性免疫细胞反应
Haribalan Perumalsamy,Xiao Xiao,Hyoung-Yun Han et al.
Haribalan Perumalsamy et al.
The prospective use of food additive titanium dioxide (E171 TiO2) in a variety of fields (food, pharmaceutics, and cosmetics) prompts proper cellular cytotoxicity and transcriptomic assessment. Interestingly, smaller-sized E171 TiO2 can tra...
Ultrasound nanodroplets loaded with Siglec-G siRNA and Fe3O4 activate macrophages and enhance phagocytosis for immunotherapy of triple-negative breast cancer [0.03%]
载有Siglec-G siRNA和Fe3O4的超声纳米液滴激活巨噬细胞并增强吞咽作用用于三阴性乳腺癌免疫治疗
Ci Yin,Guojuan Wang,Qin Zhang et al.
Ci Yin et al.
Background: The progression of triple-negative breast cancer is shaped by both tumor cells and the surrounding tumor microenvironment (TME). Within the TME, tumor-associated macrophages (TAMs) represent a significant cell...
Synergic effects of core-shell nanospheres and magnetic field for sciatic nerve regeneration in decellularized artery conduits with Schwann cells [0.03%]
磁性核壳纳米球在脱细胞动脉移植物中联合促进雪旺氏细胞修复坐骨神经损伤中的作用研究
Majid Sharifi,Majid Salehi,Somayeh Ebrahimi-Barough et al.
Majid Sharifi et al.
Numerous conduits have been developed to improve peripheral nerve regeneration. However, challenges remain, including remote control of conduit function, and programmed cell behaviors like orientation. We synthesized Fe3O4-MnO2@Zirconium-ba...
Astragali radix vesicle-like nanoparticles improve energy metabolism disorders by repairing the intestinal mucosal barrier and regulating amino acid metabolism in sleep-deprived mice [0.03%]
黄芪根泡状纳米颗粒通过修复肠黏膜屏障及调控睡眠剥夺小鼠氨基酸代谢改善能量代谢障碍
Yue Yuan,Wenjing Gao,Yunxiao Gao et al.
Yue Yuan et al.
Background: Sleep disorder is widespread and involves a variety of intricate factors in its development. Sleep deprivation is a manifestation of sleep disorder, can lead to energy metabolism disturbances, weakened immune ...
An integrated "Engage & Evasion" approach for mononuclear phagocyte system escape and efficient extracellular vesicle therapy [0.03%]
一种用于单核吞噬细胞系统逃避和有效治疗的外泌体疗法集成“吸引与逃逸”策略
Hongman Liu,Mengting Li,Bing Xiang et al.
Hongman Liu et al.
Ischemic diseases are major contributors to global morbidity and mortality, posing a substantial threat to human health. Extracellular vesicles (EVs) play an essential role in enhancing neovascularization in ischemic tissues, thereby facili...
An antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction [0.03%]
一种抗氧化纳米酶用于心肌梗死后的心脏纤维化治疗
Ziyi Gu,Xueliang Liu,Zhen Qi et al.
Ziyi Gu et al.
The excessive release of reactive oxygen species (ROS) after myocardial infarction (MI) disrupts the natural healing process, leading to cardiac fibrosis and compromising patient prognosis. However, the clinical application of many antioxid...
Metabolizable alloy clusters assemble nanoinhibitor for enhanced radiotherapy of tumor by hypoxia alleviation and intracellular PD-L1 restraint [0.03%]
一种可通过代谢的合金簇，用于通过缓解放疗肿瘤缺氧及抑制胞内PD-L1来增强放疗的纳米抑制剂
Guanwen Ding,Shengnan Liu,Xiangshan Yang et al.
Guanwen Ding et al.
Background: Cancer radiotherapy (RT) still has limited clinical success because of the obstacles including radioresistance of hypoxic tumors, high-dose X-ray-induced damage to adjacent healthy tissue, and DNA-damage repai...
Adipose-derived exosomes ameliorate skeletal muscle atrophy via miR-146a-5p/IGF-1R signaling [0.03%]
脂肪来源的外泌体通过miR-146a-5p/IGF-1R信号通路缓解骨骼肌萎缩
Mengran Qin,Jiahao Zhu,Lipeng Xing et al.
Mengran Qin et al.
The study of muscle disorders has gained popularity, with a particular emphasis on the relationship between adipose tissue and skeletal muscle. In our investigation, we discovered that the deletion of miR-146a-5p specifically in adipose tis...
Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer [0.03%]
纳米颗粒介导的基因递送和免疫调节疗法在胰腺癌治疗中的新见解及展望
Xinqiao Wang,Xue Yin,Yuxin Li et al.
Xinqiao Wang et al.
Current standard-of-care therapies have failed to improve the survival of patients with metastatic pancreatic cancer (PCA). Therefore, exploring novel therapeutic approaches for cancer targeting is of utmost need. During the past few years,...