A novel self-assembling peptide nanofiber hydrogel with glucagon-like peptide-1 functionality enhances islet survival to improve islet transplantation outcome in diabetes treatment [0.03%]
一种具有胰高血糖素样肽-1功能的自组装多肽纳米纤维水凝胶可提高移植胰岛细胞存活率以改善糖尿病治疗效果
Xiangheng Cai,Mengnan Zhang,Jiaqi Zou et al.
Xiangheng Cai et al.
Islet transplantation is a promising therapy for diabetes, yet the limited survival and functionality of transplanted islet grafts hinder optimal outcomes. Glucagon-like peptide-1 (GLP-1), an endogenous hormone, has shown potential to enhan...
Maiyier Muheyati,Guangheng Wu,Yilin Li et al.
Maiyier Muheyati et al.
Polymeric biomaterials have important applications in aiding clinical disease treatment, including drug delivery, bioimaging, and tissue engineering. Currently, conventional tumor chemotherapy faces obstacles such as poor solubility/stabili...
Click chemistry-based dual nanosystem for microRNA-122 detection with single-base specificity from tumour cells [0.03%]
基于点击化学的双纳米系统：从肿瘤细胞中检测具有单碱基特异性的微RNA-122
Agustín Robles-Remacho,Ismael Martos-Jamai,Mavys Tabraue-Chávez et al.
Agustín Robles-Remacho et al.
MicroRNAs (miRNAs) have been recognised as potential biomarkers due to their specific expression patterns in different biological tissues and their changes in expression under pathological conditions. MicroRNA-122 (miR-122) is a vertebrate-...
Bright NIR-II emissive cyanine dye-loaded lipoprotein-mimicking nanoparticles for fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma [0.03%]
一种用于荧光成像引导和靶向近红外二区光热治疗皮下胶质母细胞瘤的载cyanine染料的类脂蛋白仿生纳米粒
Haiyan Huang,Menlong Li,Jingsi Gu et al.
Haiyan Huang et al.
Cyanine dye-containing nanoparticles have widely been used in "all-in-one" NIR fluorescence imaging (FI)-guided photothermal therapy (PTT) because of their intrinsically large extinction coefficient and available physical and chemical modul...
A shielded cascade of targeted nanocarriers spanning multiple microenvironmental barriers for inflammatory disease therapy [0.03%]
一种防护级联靶向纳米载体跨越多种微环境屏障用于炎症疾病治疗
Fengyi Liu,Xu Wang,Mingxing Ren et al.
Fengyi Liu et al.
Background: The multi-biological barriers present in the inflammatory microenvironment severely limit the targeted aggregation of anti-inflammatory drugs in the lesion area. However, conventional responsive drug carriers ...
Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens [0.03%]
高效负载基因编辑工具的仿生阳离子囊泡用于体内病原体消除
Xueli Jia,Bochuan Yuan,Wanmei Wang et al.
Xueli Jia et al.
In the post-COVID-19 era, drug-resistant bacterial infections emerge as one of major death causes, where multidrug-resistant Acinetobacter baumannii (MRAB) and drug-resistant Pseudomonas aeruginosa (DRPA) represent primary pathogens. Howeve...
Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy [0.03%]
抗性淀粉嫁接铈-磺胺水杨酸无限协调聚合物协同重塑肠道代谢微环境用于炎症性肠病治疗
Jing Zhang,Liyuan Zhao,Along Liang et al.
Jing Zhang et al.
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reactive oxygen species (ROS), increased pro-inflammatory cytokines and disordered intestinal microbes. However, current t...
Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration [0.03%]
靶向脂质纳米颗粒在软骨水凝胶中递送治疗骨关节炎及调节胆固醇代谢和促进内源性软骨再生研究
Zhibo Zhao,Peng Wang,Ziyang Li et al.
Zhibo Zhao et al.
Osteoarthritis (OA) is the most common disease in aging joints and has characteristics of cartilage destruction and inflammation. It is currently considered a metabolic disease, and the CH25H-CYP7B1-RORα axis of cholesterol metabolism in c...
Hyaluronic acid-functionalized supramolecular nanophotosensitizers for targeted photoimmunotherapy of triple-negative breast cancer [0.03%]
用于三阴性乳腺癌靶向光免疫治疗的透明质酸功能化超分子纳米光敏剂
Haiyan Zhang,Hongxin Liu,Zhigang Xie et al.
Haiyan Zhang et al.
Triple-negative breast cancer (TNBC) is recognized as a particularly aggressive subtype of breast cancer that is devoid of effective therapeutic targets. Immune checkpoint inhibitors (ICIs) have demonstrated promising results in TNBC treatm...
Advances in molecular imaging and targeted therapeutics for lymph node metastasis in cancer: a comprehensive review [0.03%]
癌症淋巴结转移分子影像及靶向治疗进展：综述
Yunhao Wu,Jin Shang,Xinyue Zhang et al.
Yunhao Wu et al.
Lymph node metastasis is a critical indicator of cancer progression, profoundly affecting diagnosis, staging, and treatment decisions. This review article delves into the recent advancements in molecular imaging techniques for lymph nodes, ...