Static magnetic field-modulated mesenchymal stem cell-derived mitochondria-containing microvesicles for enhanced intervertebral disc degeneration therapy [0.03%]
基于静态磁场调控的间充质干细胞线粒体微 vesicle 分泌及其促进椎间盘退变治疗作用研究
Pengzhi Shi,Haiyang Gao,Zhangrong Cheng et al.
Pengzhi Shi et al.
Intervertebral disc degeneration (IVDD) is characterized by the senescence and declining vitality of nucleus pulposus cells (NPCs), often driven by mitochondrial dysfunction. This study elucidates that mesenchymal stem cells (MSCs) play a c...
Cationic conjugated polymer coupled non-conjugated segments for dually enhanced NIR-II fluorescence and lower-temperature photothermal-gas therapy [0.03%]
阳离子共轭聚合物偶联非共轭段用于NIR-II荧光和低温光热-气体治疗双重增强
Kexi Liu,Danni Hu,Liuliang He et al.
Kexi Liu et al.
The lack of a simple design strategy to obtain ideal conjugated polymers (CPs) with high absorbance and fluorescence (FL) in the near-infrared-II (NIR-II; 1000-1700 nm) region still hampers the success of NIR-II light-triggered phototherano...
Infection microenvironment-triggered nanoparticles eradicate MRSA by thermally amplified chemodynamic therapy and M1 macrophage [0.03%]
感染微环境触发的纳米颗粒通过热增强化学动力学治疗和M1型巨噬细胞清除金黄色葡萄球菌（MRSA）
Qimin Hong,Wei Zhang,Zhen Liu et al.
Qimin Hong et al.
It is of great significance to develop a novel approach to treat bacterial infections, as the frequent misuse of antibiotics leads to the serious problem of bacterial resistance. This study proposed antibiotic-free antibacterial nanoparticl...
A core-shell-type nanosystem promotes diabetic wound healing through Photothermal-responsive release of transforming growth factor β [0.03%]
一种核心-壳型纳米系统通过光热响应释放转化生长因子β促进糖尿病伤口愈合
Jinfei Hou,Junjin Jie,Xinwei Wei et al.
Jinfei Hou et al.
Enhanced effects of slowly co-released TGF-β3 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects [0.03%]
生物模拟羟基磷灰石涂层丝素蛋白支架缓慢共释TGF-β3和BMP-2促进软骨-骨缺损修复的协同效应增强
Jiping Chen,Yanyi Wang,Tianyi Tang et al.
Jiping Chen et al.
Bioactive agents have demonstrated regenerative potential for cell-free bone tissue engineering. Nevertheless, certain challenges persist, including ineffective delivery methods and confined therapeutic potency. Here, we demonstrated that t...
Magnetothermal-activated gene editing strategy for enhanced tumor cell apoptosis [0.03%]
磁热激活基因编辑策略增强肿瘤细胞凋亡
Mingyuan Li,Siqian Li,YueDong Guo et al.
Mingyuan Li et al.
Precise and effective initiation of the apoptotic mechanism in tumor cells is one of the most promising approaches for the treatment of solid tumors. However, current techniques such as high-temperature ablation or gene editing suffer from ...
Visualizing cancer resistance via nano-quenching and recovery detector of CD44 [0.03%]
基于纳米淬灭和恢复传感器的CD44癌症抗性可视化技术研究
Jialin Zeng,Lihua Yang,Lingke Zeng et al.
Jialin Zeng et al.
Drug resistance to chemotherapy in cancers remains significant clinical challenges. CD44 modulates cellular adhesion, migration and growth, which plays a pivotal role in driving cancer resistance and even recurrence. Despite ongoing efforts...
Therapeutic effect of small extracellular vesicles from cytokine-induced memory-like natural killer cells on solid tumors [0.03%]
细胞因子诱导的记忆样自然杀伤细胞源性小细胞外囊泡的抗肿瘤效应研究
Yinghong Shi,Yanxia Chen,Yi Wang et al.
Yinghong Shi et al.
Small extracellular vesicles (sEV) derived from diverse natural killer (NK) cell lines have proven their exceptional antitumor activities. However, sEV from human primary NK cells, especially memory-like NK cells, are rarely utilized for ca...
Rational design of ROS scavenging and fluorescent gold nanoparticles to deliver siRNA to improve plant resistance to Pseudomonas syringae [0.03%]
合理设计ROS清除和荧光金纳米颗粒以输送siRNA提高植物对青枯劳尔氏菌的抗性
Jie Qi,Yanhui Li,Xue Yao et al.
Jie Qi et al.
Bacterial diseases are one of the most common issues that result in crop loss worldwide, and the increasing usage of chemical pesticides has caused the occurrence of resistance in pathogenic bacteria and environmental pollution problems. Na...
A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration [0.03%]
一种用于调节炎性微环境以促进软骨下骨再生的纳米酶功能双层水凝胶支架
Chuan Hu,Ruipeng Huang,Jiechao Xia et al.
Chuan Hu et al.
Background: The incidence of osteochondral defects caused by trauma, arthritis or tumours is increasing annually, but progress has not been made in terms of treatment methods. Due to the heterogeneous structure and biolog...