Injectable hydrogel encapsulating siMMP13 with anti-ROS and anti-apoptotic functions for osteoarthritis treatment [0.03%]
一种用于治疗骨关节炎的可注射抗氧化和抗凋亡水凝胶載体siMMP13疗法
Zhongyin Ji,Xiaobin Ren,Jiayan Jin et al.
Zhongyin Ji et al.
Background: Osteoarthritis (OA) is a degenerative joint disease characterized by the progressive degeneration of articular cartilage, leading to pain, stiffness, and loss of joint function. The pathogenesis of OA involves...
Carbon dots-facilitated on-demand dissolution of Ca-alginate hydrogel via site-specific mineralization for wound healing [0.03%]
基于定点矿化的藻酸钙水凝胶的碳点介导的按需溶解用于伤口愈合研究
Qian Li,Chenguang Liu,Dongming Xing
Qian Li
On-demand dissolution of hydrogels has shown much potential in easy and pain-free removal of wound dressings. This work firstly describes a type of carbon dots (CDs) for dissolving Ca-alginate hydrogel via site-specific mineralization metho...
Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity [0.03%]
苦瓜提取的外泌体样纳米囊泡通过稳定p62表达来改善阿霉素的心脏毒性作用
Cong Ye,Chen Yan,Si-Jia Bian et al.
Cong Ye et al.
Background: Doxorubicin (DOX) is a first-line chemotherapeutic drug for various malignancies that causes cardiotoxicity. Plant-derived exosome-like nanovesicles (P-ELNs) are growing as novel therapeutic agents. Here, we i...
Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice [0.03%]
聚苯乙烯纳米塑料通过抑制PI3K / AKT信号通路诱导颗粒细胞凋亡、自噬和类固醇生成障碍，从而降低小鼠卵母细胞质量和生育能力
Yue Xue,Xiu Cheng,Zhang-Qiang Ma et al.
Yue Xue et al.
Background: Nanoplastics (NPs) are emerging pollutants that pose risks to living organisms. Recent findings have unveiled the reproductive harm caused by polystyrene nanoparticles (PS-NPs) in female animals, yet the intri...
Bio-orthogonal click chemistry strategy for PD-L1-targeted imaging and pyroptosis-mediated chemo-immunotherapy of triple-negative breast cancer [0.03%]
针对三阴性乳腺癌PD-L1靶向成像与细胞焦亡介导的化疗免疫治疗的生物正交点击化学策略
Yan Wang,Yanhong Chen,Ding-Kun Ji et al.
Yan Wang et al.
Background: The combination of programmed cell death ligand-1 (PD-L1) immune checkpoint blockade (ICB) and immunogenic cell death (ICD)-inducing chemotherapy has shown promise in cancer immunotherapy. However, triple-nega...
Tissue engineering strategies for spiral ganglion neuron protection and regeneration [0.03%]
螺旋神经节神经元保护和再生的组织工程策略
Bin Zhang,Yangnan Hu,Haoliang Du et al.
Bin Zhang et al.
Cochlear implants can directly activate the auditory system's primary sensory neurons, the spiral ganglion neurons (SGNs), via circumvention of defective cochlear hair cells. This bypass restores auditory input to the brainstem. SGN loss et...
Organ-on-a-chip: future of female reproductive pathophysiological models [0.03%]
芯片上的器官：女性生殖病理生理模型的未来
Zhi-Min Deng,Fang-Fang Dai,Rui-Qi Wang et al.
Zhi-Min Deng et al.
The female reproductive system comprises the internal and external genitalia, which communicate through intricate endocrine pathways. Besides secreting hormones that maintain the female secondary sexual characteristics, it also produces fol...
A multifunctional PEGylated liposomal-encapsulated sunitinib enhancing autophagy, immunomodulation, and safety in renal cell carcinoma [0.03%]
用于肾细胞癌的多功能PEG修饰脂质体载舒尼替尼制剂，可增强自噬、免疫调节和安全性
Po-Fu Yueh,Chih-Sheng Chiang,I-Jung Tsai et al.
Po-Fu Yueh et al.
Background: Sunitinib is a multikinase inhibitor used to treat patients with advanced renal cell carcinoma (RCC). However, sunitinib toxicity makes it a double-edged sword. Potent immune modulation by sunitinib extends to...
Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury [0.03%]
富血小板血浆衍生的外泌体促进脊髓损伤后的血脊髓屏障修复并减轻神经炎症
Xinyu Nie,Yanting Liu,Tianyang Yuan et al.
Xinyu Nie et al.
Spinal cord injury (SCI) compromises the blood-spinal cord barrier (BSCB) and induces neuroinflammation, potentially exacerbating neuronal damage. This underscores the importance of maintaining BSCB integrity and mitigating neuroinflammatio...
Correction: Atom-precise fluorescent copper cluster for tumor microenvironment targeting and transient chemodynamic cancer therapy [0.03%]
纠正：原子精制荧光铜簇用于肿瘤微环境靶向和瞬时化学动力癌症治疗
Zhenzhen Yang,Anli Yang,Wang Ma et al.
Zhenzhen Yang et al.
Published Erratum
Journal of nanobiotechnology. 2024 Jul 31;22(1):454. DOI:10.1186/s12951-024-02691-2 2024