Ultrafast enzyme-responsive hydrogel for real-time assessment and treatment optimization in infected wounds [0.03%]
超快酶响应性水凝胶用于感染伤口的实时评估和治疗优化
Yitao Zhao,Yong Tan,Chun Zeng et al.
Yitao Zhao et al.
Monitoring wound infection and providing appropriate treatment are crucial for achieving favorable outcomes. However, the time-consuming nature of laboratory culture tests may delay timely intervention. To tackle this challenge, a simple ye...
A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects [0.03%]
基于免疫调节和轴突再生作用的冷冻休克M2型小胶质细胞治疗策略促进脊髓损伤修复
Ermei Lu,Kecheng Zhou,Jiansen Miao et al.
Ermei Lu et al.
Recovery from spinal cord injury (SCI) is often impeded by neuroinflammation, scar formation, and limited axonal regeneration. To tackle these issues, we developed an innovative biomimetic drug delivery system using liquid nitrogen-treated ...
Metabolomics combined with physiology and transcriptomics reveal the regulation of key nitrogen metabolic pathways in alfalfa by foliar spraying with nano-selenium [0.03%]
基于叶面喷施纳米硒的代谢组与转录组及生理分析揭示氮代谢调控机制研究
Pengbo Sun,Gentu Ge,Lin Sun et al.
Pengbo Sun et al.
Selenium promotes plant growth and improves nutritional quality, and the role of nano-selenium in alfalfa in regulating nutritional quality is unknown. In this study, using the 15N labeling method, it was found that nano-selenium could prom...
Advances in 3D printing combined with tissue engineering for nerve regeneration and repair [0.03%]
结合组织工程的3D打印在神经再生与修复中的进展
Weifang Liao,Yuying Shi,Zuguang Li et al.
Weifang Liao et al.
The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative ...
Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer [0.03%]
METTL14抑制可克服ERα阳性乳腺癌中由METTL14-m6A-E2F1轴驱动的CDK4/6抑制剂耐药性
Chenlin Liu,Dong Fan,Jiahui Sun et al.
Chenlin Liu et al.
CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, and the underlying mechanisms remain challenging to full...
Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine [0.03%]
细菌外泌体在再生医学中的机遇与挑战
Jiming Guo,Zhijie Huang,Qinjing Wang et al.
Jiming Guo et al.
Extracellular vesicles (EVs) are membrane-bound vesicles that are shed or secreted from the cell membrane and enveloped by a lipid bilayer. They possess stability, low immunogenicity, and non-cytotoxicity, exhibiting extensive prospects in ...
Correction: Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy [0.03%]
纠正：工程化双靶向仿生纳米药物用于胰腺癌化疗免疫治疗
Meng Wang,Qida Hu,Junmin Huang et al.
Meng Wang et al.
Published Erratum
Journal of nanobiotechnology. 2025 Jan 4;23(1):6. DOI:10.1186/s12951-024-03033-y 2025
Facile universal strategy of presenting multifunctional short peptides for customizing desired surfaces [0.03%]
一种展示多功能短肽用于定制所需表面的简便通用策略
Ruofei Lu,Bingyang Zhao,Kaiyuan Huo et al.
Ruofei Lu et al.
Interfacial properties determine biomaterial performances, such as cell adhesion, signal exchange, and biomineralization, which affect the tissue repair cycle and efficiency of clinical applications. Peptides, as short protein sequences tha...
Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration [0.03%]
用于生物治疗的介孔普鲁士蓝纳米粒子神经导管，可降低氧化应激、抑制炎症和促进神经再生
Junyi Zhu,Yijia Zhang,Yinuo Sun et al.
Junyi Zhu et al.
The applications of nanomaterials in regenerative medicine encompass a broad spectrum. The functional nanomaterials, such as Prussian blue and its derivative nanoparticles, exhibit potent anti-inflammatory and antioxidant properties. By com...
Targeting AURKA with multifunctional nanoparticles in CRPC therapy [0.03%]
靶向AURKA的多功能纳米颗粒在治疗CRPC中的应用
Bin Deng,Binghu Ke,Qixing Tian et al.
Bin Deng et al.
Castration-resistant prostate cancer (CRPC) presents significant therapeutic challenges due to its aggressive nature and poor prognosis. Targeting Aurora-A kinase (AURKA) has shown promise in cancer treatment. This study investigates the ef...