Organoid development and applications in gynecological cancers: the new stage of tumor treatment [0.03%]
类器官在妇科肿瘤治疗中的发展和应用：治疗新阶段
Yang Li,Meiying Qin,Ning Liu et al.
Yang Li et al.
Gynecologic cancers (GCs), including cervical cancer (CC), ovarian cancer (OC), endometrial cancer (EC), as well as vulvar and vaginal cancers, represent major health threats to women, with increasing incidence rates observed globally. Conv...
MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy [0.03%]
一种用于增强生物能治疗的智能 Arenobufagin 纳米复合材料，具有代谢抑制功能，并集成了光热和化学动力及化疗效应的多功能MOF衍生材料
Lihua Chen,Jiaying Yang,Lingyu Jia et al.
Lihua Chen et al.
Bioenergetic therapy based on tumor glucose metabolism is emerging as a promising therapeutic modality. To overcome the poor bioavailability and toxicity of arenobufagin (ArBu), a MOF-derived intelligent nanosystem, ZIAMH, was designed to f...
Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus [0.03%]
口服胰岛素递药系统治疗二型糖尿病的新进展ritical updates on oral insulin drug delivery systems for type 2 diabetes mellitus
Chan Yew Low,Wei Ling Gan,Su Jeat Lai et al.
Chan Yew Low et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood gluco...
Lipid-encapsulated gold nanoparticles: an advanced strategy for attenuating the inflammatory response in SARS-CoV-2 infection [0.03%]
脂质封装的金纳米颗粒：减轻SARS-CoV-2感染中炎症反应的先进策略
Sanjeevram Dhandapani,Yujeong Ha,Rongbo Wang et al.
Sanjeevram Dhandapani et al.
Background: Nanodrugs play a crucial role in biomedical applications by enhancing drug delivery. To address safety and toxicity concerns associated with nanoparticles, lipid-nanocarrier-based drug delivery systems have em...
A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression [0.03%]
响应ROS的水凝胶负载基质金属蛋白酶-13 siRNA纳米载体抑制骨关节炎进展
Qiuyang Wang,Kai Feng,Guangsheng Wan et al.
Qiuyang Wang et al.
RNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), the most prevalent degenerative joint disease. However, the synergistic effects of these ...
Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-induced immunosuppression [0.03%]
基于尺寸效应的硒纳米颗粒改善抗氧化活性调节抗PI3K-mTOR和Ras-MEK通路治疗脊髓损伤以避免激素休克引起的免疫抑制
Peixin Liu,Xiaodong Liu,Zihao Wu et al.
Peixin Liu et al.
Spinal cord injury (SCI) is a critical condition affecting the central nervous system that often has permanent and debilitating consequences, including secondary injuries. Oxidative damage and inflammation are critical factors in secondary ...
Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis [0.03%]
一种用于诱导细胞焦亡从而治疗胶质母细胞瘤的工程类铂多酚纳米复合物化疗免疫疗法
Xinyan Hao,Yucheng Tang,Wenjie Xu et al.
Xinyan Hao et al.
Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP...
Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis [0.03%]
来源于脐带间充质基质细胞的临床级外泌体：作为膝关节骨关节炎治疗药物的药代动力学和首次人体关节内验证研究
Aliosha I Figueroa-Valdés,Patricia Luz-Crawford,Yeimi Herrera-Luna et al.
Aliosha I Figueroa-Valdés et al.
Osteoarthritis (OA) is a joint disease characterized by articular cartilage degradation. Persistent low-grade inflammation defines OA pathogenesis, with crucial involvement of pro-inflammatory M1-like macrophages. While mesenchymal stromal ...
A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation [0.03%]
负载Apelin-13的反应性氧中间体响应型水凝胶通过调节脊髓损伤后的M1/M2巨噬细胞极化和神经炎症促进脊髓修复
Zhiyue Li,Qun Zhao,Jiahui Zhou et al.
Zhiyue Li et al.
Spinal cord injury (SCI) is a chronic condition whereby persistent aberrant macrophage activation hinders the repair process. During acute trauma, dominant M1 macrophages produce high levels of reactive oxygen species (ROS), leading to incr...
Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis [0.03%]
基因工程仿生型ATP响应纳米酶用于治疗心脏纤维化
Xueli Zhao,Yuze Qin,Bowen Li et al.
Xueli Zhao et al.
Background: Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death. However, currently, there are no therapeutic strategies a...