Tumor targeting peptide TMTP1 modified Antigen capture Nano-vaccine combined with chemotherapy and PD-L1 blockade effectively inhibits growth of ovarian cancer [0.03%]
肿瘤靶向肽TMTP1修饰的抗原捕获纳米疫苗联合化疗和PD-L1抑制有效抑制卵巢癌生长
Ying Zhou,Rui Wei,Ling Wang et al.
Ying Zhou et al.
The mortality of ovarian cancer (OC) has long been the highest among gynecological malignancies. Although OC is considered to be an immunogenic tumor, the effect of immunotherapy is not satisfactory. The immunosuppressive microenvironment i...
Alkaline phosphatase-activated prodrug system based on a bifunctional CuO NP tandem nanoenzyme for on-demand bacterial inactivation and wound disinfection [0.03%]
一种基于双功能CuO纳米酶的碱性磷酸酶激活型前药系统实现按需杀菌与创面消毒
Quan-Quan Zhuang,Zhi-Shan Zhang,Ting-Jin Zheng et al.
Quan-Quan Zhuang et al.
Nanozymes are promising antimicrobials, as they produce reactive oxygen species (ROS). However, the intrinsic lack of selectivity of ROS in distinguishing normal flora from pathogenic bacteria deprives nanozymes of the necessary selectiviti...
The biological applications of near-infrared optical nanomaterials in atherosclerosis [0.03%]
近红外光学纳米材料在动脉粥样硬化生物医学应用中的研究进展
Lin Shen,Yanran Bi,Junchao Yu et al.
Lin Shen et al.
Purpose of review: Atherosclerosis, a highly pathogenic and lethal disease, is difficult to locate accurately via conventional imaging because of its scattered and deep lesions. However, second near-infrared (NIR-II) nano...
Yanling Zhuo,Huanxuan Zeng,Chunyu Su et al.
Yanling Zhuo et al.
Biomaterials are substances that can be injected, implanted, or applied to the surface of tissues in biomedical applications and have the ability to interact with biological systems to initiate therapeutic responses. Biomaterial-based vacci...
Croconaine-based NIR-II fluorescence imaging-guided tumor photothermal therapy induces long-term antitumor immune memory [0.03%]
一种基于Croconaine的近红外二区荧光成像引导的肿瘤光热治疗诱导长期抗肿瘤免疫记忆效应
Yafang Dong,Huifang Wang,Xiaodong Zhang et al.
Yafang Dong et al.
Photothermal therapy (PTT) for cancers guided by optical imaging has recently shown great potential for precise diagnosis and efficient therapy. The second near-infrared window (NIR-II, 1000-1700 nm) fluorescence imaging (FLI) is highly des...
Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles [0.03%]
电荷敏感的PEGDA纳米颗粒直接经肺部给药后小鼠肺部抗原提呈细胞吞噬作用的年龄相关变化响应研究
Emma R Sudduth,Aida López Ruiz,Michael Trautmann-Rodriguez et al.
Emma R Sudduth et al.
Background: Current needle-based vaccination for respiratory viruses is ineffective at producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to the resident local pulmonary immune cel...
Neutrophil membrane-derived nanoparticles protect traumatic brain injury via inhibiting calcium overload and scavenging ROS [0.03%]
中性粒细胞膜衍生的纳米粒子通过抑制钙超载和清除ROS治疗创伤性脑损伤
Hongqing Li,Duo Sun,Zhenghuan Zhao et al.
Hongqing Li et al.
The secondary injury is more serious after traumatic brain injury (TBI) compared with primary injury. Release of excessive reactive oxygen species (ROS) and Ca2+ influx at the damaged site trigger the secondary injury. Herein, a neutrophil-...
Crosslinked-hybrid nanoparticle embedded in thermogel for sustained co-delivery to inner ear [0.03%]
交联杂化纳米颗粒包载的热致凝胶内耳共递送研究
Neeraj S Thakur,Iulia Rus,Aidan Herbert et al.
Neeraj S Thakur et al.
Treatment-induced ototoxicity and accompanying hearing loss are a great concern associated with chemotherapeutic or antibiotic drug regimens. Thus, prophylactic cure or early treatment is desirable by local delivery to the inner ear. In thi...
Hemoglobin nanoclusters-mediated regulation of KPNA4 in hypoxic tumor microenvironment enhances photodynamic therapy in hepatocellular carcinoma [0.03%]
缺氧微环境下血红蛋白纳米聚集体介导KPNA4调节增强肝细胞癌光动力治疗
Yiliang Wang,Nu Li,Letian Qu et al.
Yiliang Wang et al.
Background: Hepatocellular carcinoma (HCC) is a highly malignant tumor known for its hypoxic environment, which contributes to resistance against the anticancer drug Sorafenib (SF). Addressing SF resistance in HCC require...
Oral administration of Robinia pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis caused by hypoxia through inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation [0.03%]
口服辽阳春黄豆花外泌体类似纳米颗粒通过抑制HIF-1α和HIF-2α介导的脂质过氧化来减轻缺氧引起的胃和小肠粘膜铁死亡
Dezhi Wang,Heng Zhang,Xingchen Liao et al.
Dezhi Wang et al.
The prevention and treatment of gastrointestinal mucosal injury caused by a plateau hypoxic environment is a clinical conundrum due to the unclear mechanism of this syndrome; however, oxidative stress and microbiota dysbiosis may be involve...