Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα [0.03%]
母体接触富勒烯酚通过抑制雌三醇合成和降低ERα损伤小鼠胎盘发育
Qing He,Jiali Yuan,Huihui Yang et al.
Qing He et al.
Fullerenols, a water-soluble polyhydroxy derivative of fullerene, hold promise in medical and materials science due to their unique properties. However, concerns about their potential embryotoxicity remain. Using a pregnancy mouse model and...
Haifan Liu,Xingyue Jin,Suyi Liu et al.
Haifan Liu et al.
Natural products, recognized for their potential in disease prevention and treatment, have been integrated with advanced nano-delivery systems to create natural product-based nanomedicines, offering innovative approaches for various disease...
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration [0.03%]
负载铈锰纳米颗粒和神经生长因子的水凝胶通过调节免疫微环境和促进神经元再生来增强脊髓损伤修复
Zhaoyang Gong,Zhenhao Chen,Dachuan Li et al.
Zhaoyang Gong et al.
Background: Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims to develop a ...
Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO2 nanoparticles via mTOR-TFEB pathway autophagic flux inhibition [0.03%]
通过mTOR-TFEB途径自噬流抑制以加载DOX的SiO2纳米粒子增强肝细胞癌治疗
Huanyu Chen,Jun Liu,Zhichao Cao et al.
Huanyu Chen et al.
Chemotherapeutic drugs often fail to provide long-term efficacy due to their lack of specificity and high toxicity. To enhance the biosafety and reduce the side effects of these drugs, various nanocarrier delivery systems have been develope...
Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites [0.03%]
一种基于单一结构单元同时包含两种HPV主要免疫原位点的三型疫苗的设计
Ciying Qian,Jie Chen,Yurou Yang et al.
Ciying Qian et al.
The numerous high-risk carcinogenic types of human papillomavirus (HR-HPV) that lack vaccine protection underscore the urgent need to develop broader-spectrum HPV vaccines. This study addresses this need by focusing on HR-HPV types 53, 56, ...
Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models [0.03%]
用于原位肿瘤模型精准术中影像及光热消融的超亮对比剂和拉曼协同增强技术
Yiqun Ma,Shuchi Xia,Annan Hu et al.
Yiqun Ma et al.
Background: Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imaging emerges as a promising modality due to its high spatial resolution and signal stabi...
Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases [0.03%]
使用人工氧载体输送氧气进行治疗展示了治疗广泛疾病的可能性
Nijaya Mohanto,Himangsu Mondal,Young-Joon Park et al.
Nijaya Mohanto et al.
Artificial oxygen carriers have emerged as potential substitutes for red blood cells in situations of major blood loss, including accidents, surgical procedures, trauma, childbirth, stomach ulcers, hemorrhagic shock, and blood vessel ruptur...
Biofunctionalized patterned platform as microarray biochip to supervise delivery and expression of pDNA nanolipoplexes in stem cells via mechanotransduction [0.03%]
用于监督经机械转导的干细胞中pDNA纳米脂复合物递送和表达的生物功能化微图案化平台-微阵列芯片
Mingkui Shen,Yan Hou,Shihui Xu et al.
Mingkui Shen et al.
Biochips are widely applied to manipulate the geometrical morphology of stem cells in recent years. Patterned antenna-like pseudopodia are also probed to explore the influence of pseudopodia formation on gene delivery and expression on bioc...
Correction: Silver nanoparticle induced immunogenic cell death can improve immunotherapy [0.03%]
纠正：银纳米颗粒诱导的免疫原性细胞死亡可以改善免疫治疗
Ara Sargsian,Xanthippi Koutsoumpou,Hermon Girmatsion et al.
Ara Sargsian et al.
Published Erratum
Journal of nanobiotechnology. 2025 Jan 17;23(1):21. DOI:10.1186/s12951-024-03081-4 2025
M cells targeted H. pylori antigen SAM-FAdE displayed on bacterium-like particles induce protective immunity [0.03%]
靶向M细胞的幽门螺旋杆菌抗原SAM-FAdE菌样颗粒疫苗诱导保护性免疫反应
Furui Zhang,Jiale Chen,Zhen Zhang et al.
Furui Zhang et al.
Background: Helicobacter pylori (H. pylori), a specific bacterium capable of surviving in the acidic environment of the stomach, has been recognized as a group of causative agents of gastric cancer. Therefore, the develop...