Au-modified ceria nanozyme prevents and treats hypoxia-induced pulmonary hypertension with greatly improved enzymatic activity and safety [0.03%]
改良金颗粒的氧化铈纳米酶可改善缺氧性肺动脉高压病理与毒理学指标
Rui Xiao,Jia Liu,Lin Shi et al.
Rui Xiao et al.
Background: Despite recent advances the prognosis of pulmonary hypertension remains poor and warrants novel therapeutic options. Extensive studies, including ours, have revealed that hypoxia-induced pulmonary hypertension...
Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos [0.03%]
装载了间充质干细胞外泌体的基因编辑软骨细胞水凝胶的制备及评价其治疗骨关节炎的效果
Renyi Zhou,Jiarong Guo,Zhe Jin
Renyi Zhou
This study investigated the mechanism of the extracellular matrix-mimicking hydrogel-mediated TGFB1/Nrf2 signaling pathway in osteoarthritis using bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos). A GMOCS-Exos hydrogel was sy...
Fusiform nanoparticle boosts efficient genetic transformation in Sclerotinia sclerotiorum [0.03%]
杆状纳米颗粒可促进Sclerotinia sclerotiorum高效的遗传转化
Yijuan Ding,Nan Yang,Yi Lu et al.
Yijuan Ding et al.
Background: Sclerotinia sclerotiorum is a highly destructive phytopathogenic fungus that poses a significant threat to a wide array of crops. The current constraints in genetic manipulation techniques impede a thorough co...
Oxygen vacancy-engineered cerium oxide mediated by copper-platinum exhibit enhanced SOD/CAT-mimicking activities to regulate the microenvironment for osteoarthritis therapy [0.03%]
铜-铂介导的氧空位工程制备氧化铈可增强类SOD/CAT活性以调节骨关节炎治疗微环境
Junxu Yang,Shihui Xiao,Jiejia Deng et al.
Junxu Yang et al.
Cerium oxide (CeO2) nanospheres have limited enzymatic activity that hinders further application in catalytic therapy, but they have an "oxidation switch" to enhance their catalytic activity by increasing oxygen vacancies. In this study, ac...
VMT/ACP/Dextran composite nanosheets against dental caries through promoting mineralization of dentin tubules, pH buffering, and antibacterial [0.03%]
丝素蛋白/VTC/右旋糖酐纳米复合材料抗龋机理研究
Yanting Xu,Juan Mou,Jiewen Dai
Yanting Xu
Dental caries is a worldwide public healthcare concern, and is closely related to the acidic environment that caused by bacterial decomposition of food. In this study, a two-step ion exchange liquid-phase stripping method was applied to str...
A structured biomimetic nanoparticle as inflammatory factor sponge and autophagy-regulatory agent against intervertebral disc degeneration and discogenic pain [0.03%]
一种针对椎间盘退变和椎间盘源性疼痛的炎症因子海绵及自噬调节剂结构型仿生纳米颗粒
Kanglu Li,Wenbo Yang,Xuanzuo Chen et al.
Kanglu Li et al.
Lower back pain (LBP) is a common condition closely associated with intervertebral disc degeneration (IDD), causing a significant socioeconomic burden. Inflammatory activation in degenerated discs involves pro-inflammatory cytokines, dysreg...
M2 macrophage-polarized anti-inflammatory microneedle patch for accelerating biofilm-infected diabetic wound healing via modulating the insulin pathway [0.03%]
一种用于通过调节胰岛素信号通路促进生物膜感染性糖尿病创面修复的M2巨噬细胞抗炎微针贴片
Yushan Yang,Limin Fan,Jingsi Jiang et al.
Yushan Yang et al.
Macrophages play a pivotal role in the healing of diabetic ulcers. The sustained elevation of glucose levels damages the insulin signaling pathway in macrophages, leading to dysfunctional macrophages that struggle to transition from pro-inf...
Extracellular vesicles: opening up a new perspective for the diagnosis and treatment of mitochondrial dysfunction [0.03%]
细胞外囊泡：揭示线粒体功能障碍诊断和治疗的新视角
Jiali Li,Tangrong Wang,Xiaomei Hou et al.
Jiali Li et al.
Mitochondria are crucial organelles responsible for energy generation in eukaryotic cells. Oxidative stress, calcium disorders, and mitochondrial DNA abnormalities can all cause mitochondrial dysfunction. It is now well documented that mito...
In vivo fluorescence imaging of nanocarriers in near-infrared window II based on aggregation-caused quenching [0.03%]
基于聚集致猝灭的近红外二区窗口纳米载体影像检测
Zichen Zhang,Chang Liu,Yi Lu et al.
Zichen Zhang et al.
Accurate fluorescence imaging of nanocarriers in vivo remains a challenge owing to interference derived mainly from biological tissues and free probes. To address both issues, the current study explored fluorophores in the near-infrared (NI...
Oral enzyme-responsive nanoprobes for targeted theranostics of inflammatory bowel disease [0.03%]
口服酶响应性纳米探针用于炎症性肠病的精准诊疗
Lin Cao,Dengyi Duan,Jing Peng et al.
Lin Cao et al.
Background: Inflammatory bowel disease (IBD) is a progressive and debilitating inflammatory disease of the gastrointestinal tract (GIT). Despite recent advances, precise treatment and noninvasive monitoring remain challen...