Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway [0.03%]
叶酸修饰的姜源外泌体通过PI3K-AKT途径重塑免疫微环境治疗类风湿性关节炎
Ruina Han,Dongyang Zhou,Ning Ji et al.
Ruina Han et al.
Rheumatoid arthritis (RA), a form of autoimmune inflammation, is marked by enduring synovial inflammation and the subsequent impairment of joint function. Despite the availability of conventional treatments, they are often marred by signifi...
Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification [0.03%]
基于pH逆转的抗肿瘤纳米策略研究进展：碱性递送与酸性诱导
Qiufang Gong,Xuejiao Song,Yao Tong et al.
Qiufang Gong et al.
The acidic tumor microenvironment, a hallmark of many solid tumors, is primarily induced by the high glycolytic rate of tumor cells. To avoid acidosis, tumor cells ingeniously maintain an acidic extracellular pH while keeping a relatively a...
Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) [0.03%]
聚苯乙烯纳米（微）塑料增强氟氰戊菊酯在模型昆虫家蚕（Bombyx mori）中的蓄积和毒性
Abrar Muhammad,Zhaoyi Qian,Yu Li et al.
Abrar Muhammad et al.
Background: Nano(micro)plastics (NMPs) and agrochemicals are ubiquitous pollutants. The small size and physicochemical properties of NMPs make them potential carriers for pollutants, affecting their bioavailability and im...
Highly effective treatment of bacterial infection-accompanied wounds by fat extract-embedded phototherapeutic hydrogel [0.03%]
一种高效治疗细菌感染伤口的脂肪萃取物嵌入型光疗水凝胶疗法
Haonan Wang,Yingnan Xiao,Deli Zhuge et al.
Haonan Wang et al.
Phototherapy presents an effective approach for treating localized methicillin-resistant Staphylococcus aureus (MRSA) infections; however, the tradeoff between therapeutic efficacy and negative off-target effect persists. To address these i...
Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis [0.03%]
一种基于硒的氯ogenic酸纳米颗粒通过调节Mapk8ip1/MAPK和Itga2b/PI3k-AKT轴协同治疗急性肺损伤的抗氧化/抗炎方法
Huizhen Xing,Xinwei Bai,Xiaoying Pei et al.
Huizhen Xing et al.
Oxidative stress and inflammatory dysregulation play crucial roles in pathogenesis of acute lung injury (ALI), and their cyclic synergy drives excessive inflammatory responses and further exacerbates ALI. Therefore, new effective strategies...
Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy [0.03%]
装载miR-205的外泌体：治疗眼新生血管化的双重策略
Hui-Ying Zhang,Qiu-Yang Zhang,Qing Liu et al.
Hui-Ying Zhang et al.
Pathological neovascularization is a hallmark of many vision-threatening diseases. However, some patients exhibit poor responses to current anti-VEGF therapies due to resistance and limited efficacy. Recent studies have highlighted the role...
Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence [0.03%]
使用mRNA-LNP传递FGF18通过减轻软骨细胞衰老保护软骨免于退行性变
Keyu Kong,Baixing Li,Yongyun Chang et al.
Keyu Kong et al.
Background: Osteoarthritis (OA) is a degenerative joint disease with an immense unmet medical need. FGF18 protein is a potential regenerative factor for cartilage repair. However, traditional protein delivery methods have...
Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa [0.03%]
通过PLGA颗粒上的UV触发聚合作用制备粘附性聚电解质涂层以增强药物向炎症肠黏膜的传递
Jie Zhang,Yi-Jing Yin,Xing-Wang Wang et al.
Jie Zhang et al.
Administering medication precisely to the inflamed intestinal sites to treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, the inflammation damaged mucosa contains a large number of amino groups which are p...
PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors [0.03%]
PLGA使常规非荧光分子具备发光性能以触发肿瘤中1O2诱导的细胞焦亡和免疫响应
Lan Zou,Rujing Wang,Mengnan Zhao et al.
Lan Zou et al.
Pyroptosis, a recently identified cellular demise regulated by gasdermin family proteins, is emerging as a promising avenue in cancer immunotherapy. However, the realm of light-controlled pyroptosis in cancer cells remains largely unexplore...
Multi-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors [0.03%]
可控靶向纳米材料介导的多途径氧化应激放大光免疫治疗肿瘤
Song Li,Yunheng Liu,Xiaokang Zhang et al.
Song Li et al.
Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared with mono-treatment regimens. However, its use is associated with drawbacks, such as insufficient reactive oxyg...