Yin-Yang: two sides of extracellular vesicles in inflammatory diseases [0.03%]
炎性疾病中炎性小体的双面效应：阴阳理论的新视角
Bin Zeng,Ying Li,Nawaz Khan et al.
Bin Zeng et al.
The concept of Yin-Yang, originating in ancient Chinese philosophy, symbolizes two opposing but complementary forces or principles found in all aspects of life. This concept can be quite fitting in the context of extracellular vehicles (EVs...
Stem cell recruitment polypeptide hydrogel microcarriers with exosome delivery for osteoarthritis treatment [0.03%]
用于治疗骨关节炎的干细胞招募多肽水凝胶微载体及外泌体递送
Lei Yang,Wenzhao Li,Yuanjin Zhao et al.
Lei Yang et al.
With the accelerated aging tendency, osteoarthritis (OA) has become an intractable global public health challenge. Stem cells and their derivative exosome (Exo) have shown great potential in OA treatment. Research in this area tends to deve...
Endogenous capsid-forming protein ARC for self-assembling nanoparticle vaccines [0.03%]
内源性衣壳形成蛋白ARC用于自组装纳米颗粒疫苗
Yu Li,Xiaofan Zhao,Jiaqi Tang et al.
Yu Li et al.
The application of nanoscale scaffolds has become a promising strategy in vaccine design, with protein-based nanoparticles offering desirable avenues for the biocompatible and efficient delivery of antigens. Here, we presented a novel endog...
Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy [0.03%]
基于天然药物的碳点作为新型口服抗氧化给药策略用于溃疡性结肠炎治疗
Tong Wu,Xue Bai,Yue Zhang et al.
Tong Wu et al.
Background: Ulcerative colitis (UC) is a chronic intestinal inflammation, resulting in a global healthcare challenge with no real specific medicine. Natural medicines are recognized as a potential clinical alternative the...
Bacterial derivatives mediated drug delivery in cancer therapy: a new generation strategy [0.03%]
癌症治疗中的细菌衍生物介导的药物递送：新一代策略
Muhammad Ijaz,Ikram Hasan,Tamoor Hamid Chaudhry et al.
Muhammad Ijaz et al.
Cancer is measured as a major threat to human life and is a leading cause of death. Millions of cancer patients die every year, although a burgeoning number of researchers have been making tremendous efforts to develop cancer medicine to fi...
Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus [0.03%]
妊娠糖尿病患者外泌体衍生的循环miR-1299通过靶向STAT3 / FAM3A轴破坏肝脏葡萄糖稳态
Xuyang Chen,Xinyi Tao,Min Wang et al.
Xuyang Chen et al.
Background: Extracellular vesicles (EVs) are membrane-enclosed structures containing lipids, proteins, and RNAs that play a crucial role in cell-to-cell communication. However, the precise mechanism through which circulat...
Youthful small extracellular vesicles restore the function and reparative capacity of inflammatory-impaired periodontal ligament stem cells via delivering protein biglycan for bone regeneration [0.03%]
青春小细胞外囊泡通过递送蛋白biglycan修复受损的牙周韧带干细胞功能及骨组织再生潜能
Jiaqi Yang,Junxiang Su,Zhuo Sun et al.
Jiaqi Yang et al.
Regenerating inflamed bone defects represents a severe clinical challenge due to the undesirable inflammatory microenvironment. The inflammatory stimulus poses a weighty threat to the regenerative capacity of endogenously derived mesenchyma...
Preparation and characterization of BSA-loaded liraglutide and platelet fragment nanoparticle delivery system for the treatment of diabetic atherosclerosis [0.03%]
用于治疗糖尿病动脉粥样硬化的载BSA的利拉鲁肽和血小板片段纳米递送系统制备及表征
Mingping He,Ming Fang,Limin Fan et al.
Mingping He et al.
Background: Diabetic atherosclerosis is one of the main causes of morbidity and mortality worldwide, but its therapeutic options are limited. Liraglutide (LIR), a synthetic analog of GLP-1 approved as an anti-obesity drug...
Multi-omics analyses reveal the responses of wheat (Triticum aestivum L.) and rhizosphere bacterial community to nano(micro)plastics stress [0.03%]
多组学分析揭示纳米（微）塑料胁迫对小麦和根系细菌群落的影响
Ming Zhuang,Chengkui Qiao,Lijun Han et al.
Ming Zhuang et al.
The pervasive existence of nanoplastics (NPs) and microplastics (MPs) in soil has become a worldwide environmental concern. N/MPs exist in the environment in a variety of forms, sizes, and concentrations, while multi-omics studies on the co...
Nanoparticle-mediated cell pyroptosis: a new therapeutic strategy for inflammatory diseases and cancer [0.03%]
纳米颗粒介导的细胞炎性坏死：炎症和癌症治疗的新策略
Lin Zhao,Haipeng Cheng,Zhongyi Tong et al.
Lin Zhao et al.
Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized by cell swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses and is a promising strategy for canc...