A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer [0.03%]
一种针对NCL的新适配体-药物缀合物有望成为治疗食道癌的疗法
Xue Zheng,Ying Wang,Huaiyu Duan et al.
Xue Zheng et al.
Esophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens. Nucleolin (NCL) is overexpressed in many tumors, and drugs specifically targeting NCL ...
Peripheral nerves modulate the peri-implant osteogenesis under type 2 diabetes through exosomes derived from schwann cells via miR-15b-5p/Txnip signaling axis [0.03%]
外周神经通过雪旺细胞衍生的微泡中的miR-15b-5p / TxnIp信号轴在2型糖尿病中调节 peri-植入骨发生
Yingying Wang,Fang Qu,Yaqin Wu et al.
Yingying Wang et al.
Studies have shown that the prognosis of dental implant treatment in patients with diabetes is not as good as that in the non-diabetes population. The nerve plays a crucial role in bone metabolism, but the role and the mechanism of peripher...
aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound [0.03%]
通过低强度脉冲超声触发的多西他赛载相变纳米粒介导的胰腺癌免疫治疗及肿瘤微环境重塑研究
Yi Tang,Qingling Shen,Peng Lin et al.
Yi Tang et al.
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant f...
Correction: Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis [0.03%]
订正：氧化铈纳米颗粒通过调节线粒体氧化磷酸化和有氧糖酵解的平衡来改善肾纤维化
Mengling Wang,Feng Zeng,Fengling Ning et al.
Mengling Wang et al.
Published Erratum
Journal of nanobiotechnology. 2025 Jan 28;23(1):50. DOI:10.1186/s12951-024-03089-w 2025
An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing [0.03%]
一种抗菌、抗氧化和止血的水凝胶可加速感染性伤口愈合
Ziyi Zhou,Dengjun Zhang,Xuchao Ning et al.
Ziyi Zhou et al.
Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in the microenvironment of wound infection to promote wound healing. In this study, a multifunctional hydrogel drug delivery syste...
Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS [0.03%]
基於聚氧杂金属化合物的可注射共聚集液通过清除ROS抑制射频消融不完全后的肝癌转移
Meilin Yang,Die Liu,Yan Tan et al.
Meilin Yang et al.
Background: Incomplete radiofrequency ablation (iRFA) stimulates residual hepatocellular carcinoma (HCC) metastasis, leading to a poor prognosis for patients. Therefore, it is imperative to develop an effective therapeuti...
Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing [0.03%]
负载硅酸钙刺激的脂肪间充质干细胞源外泌体的胶原水凝胶的免疫调控作用促进糖尿病创面修复
Yen-Hong Lin,Yeh Chen,En-Wei Liu et al.
Yen-Hong Lin et al.
Diabetic wounds are characterized by chronic inflammation, reduced angiogenesis, and insufficient collagen deposition, leading to impaired healing. Extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (ADSC) offe...
Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants [0.03%]
结合Fc片段的纳米盘可恢复针对不断进化的SARS-CoV-2变异株效力减弱的中和抗体的功效
Jaehyeon Hwang,Soyun Choi,Beom Kyu Kim et al.
Jaehyeon Hwang et al.
Passive antibody therapies, typically administered via parenteral routes, have played a crucial role in the initial response to the COVID-19 pandemic. However, the ongoing evolution of SARS-CoV-2 has revealed significant limitations of this...
Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms [0.03%]
兼具抗菌和抗生物被膜作用的光动力/光热协同靶向细菌纳米系统
Xiao Wang,Wenxuan Shi,Yu Jin et al.
Xiao Wang et al.
The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constrain...
Neutrophil-macrophage hybrid membrane-coated prussian blue nanozyme for ulcerative colitis treatment and mechanistic insights [0.03%]
用于治疗溃疡性结肠炎和机制研究的中性粒细胞-巨噬细胞杂化膜包被普鲁士蓝纳米酶
Chunli Hu,Yanhui Wang,Shengtao Liao et al.
Chunli Hu et al.
Background: Ulcerative colitis (UC) is a chronic and recurrent digestive tract disease that can lead to significant morbidity and mortality. The pathogenesis of UC is intricately associated with the presence of reactive o...