Probiotic active gel promotes diabetic wound healing through continuous local glucose consumption and antioxidant [0.03%]
益生菌活性凝胶通过持续局部消耗葡萄糖和抗氧化促进糖尿病伤口愈合
Yingshuai Wang,Lihua Shi,Junna Lu et al.
Yingshuai Wang et al.
Background: Diabetic foot ulcers (DFU) are severe complications of diabetes, posing significant health and societal challenges. Accumulation of reactive oxygen species (ROS) and elevated glucose levels are primary factors...
Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-derived carbon dots [0.03%]
通过维持氧化还原平衡、诱导巨噬细胞重编程和恢复滑膜纤维母细胞样细胞稳态有效缓解类风湿性关节炎的二甲双胍衍生碳点
Rui Zhang,Xingyu Lin,Rongjie Lin et al.
Rui Zhang et al.
Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, synovial hyperplasia and fibrosis are the main characteristic of microenvironment in rheumatoid arthritis (RA). Macrophages and fibroblast-like synoviocytes (F...
From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges [0.03%]
从微观到宏观：纳米技术揭开急性胰腺炎的面纱——新一代治疗方案应运而生
Wei Du,Xinyue Wang,Yuyan Zhou et al.
Wei Du et al.
Acute pancreatitis (AP) is a disease characterized by an acute inflammatory response in the pancreas. This is caused by the abnormal activation of pancreatic enzymes by a variety of etiologic factors, which results in a localized inflammato...
Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing [0.03%]
用于促进糖尿病伤口愈合的纳米敷料 topical 应用的一氧化氮生成新策略
Dan Xia,Ying Guo,Ruodan Xu et al.
Dan Xia et al.
The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production...
Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens [0.03%]
禽流感mRNA疫苗的血凝素抗原对无特定病原鸡感染不同H5N1病毒株具有完全保护力
Zhaoyang Wang,Chongyu Tian,Jiahang Zhu et al.
Zhaoyang Wang et al.
Background: The rapid mutation of avian influenza virus (AIV) poses a significant threat to both the poultry industry and public health. Herein, we have successfully developed an mRNA-LNPs candidate vaccine for H5 subtype...
Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis [0.03%]
双模式驱动的纳米马达靶向炎症性巨噬细胞用于动脉粥样硬化磁共振成像和协同治疗
Min Wei,Qiaoji Jiang,Shuang Bian et al.
Min Wei et al.
With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, ...
Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis [0.03%]
表皮干细胞源外泌体通过 miR-203a-3p/PIK3CA 轴将肌成纤维细胞去分化为皮肤再生中抗瘢痕的干细胞样细胞
Shixin Zhao,Haoran Kong,Dahu Qi et al.
Shixin Zhao et al.
Hypertrophic scar (HS) is a common fibroproliferative disorders with no fully effective treatments. The conversion of fibroblasts to myofibroblasts is known to play a critical role in HS formation, making it essential to identify molecules ...
Anti-inflammatory coupled anti-angiogenic airway stent effectively suppresses tracheal in-stents restenosis [0.03%]
一种抗炎及抗血管生成化气道内支架可有效抑制气管内支架再狭窄
Yanan Zhao,Yiming Liu,Jiheng Shan et al.
Yanan Zhao et al.
Excessive vascularization during tracheal in-stent restenosis (TISR) is a significant but frequently overlooked issue. We developed an anti-inflammatory coupled anti-angiogenic airway stent (PAGL) incorporating anlotinib hydrochloride and s...
CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis [0.03%]
用于有效早期诊断和治疗肺纤维化的CT敏化纳米探针
Jiwei Hou,Qijian Ji,Tianyu Tang et al.
Jiwei Hou et al.
Early diagnosis is critical for providing a timely window for effective therapy in pulmonary fibrosis (PF); however, achieving this remains a significant challenge. The distinct honeycombing patterns observed in computed tomography (CT) for...
Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? [0.03%]
prominosome-一种含 prominin-1/cd133 的细胞外囊泡？
Jana Karbanová,Kristina Thamm,Christine A Fargeas et al.
Jana Karbanová et al.
Extracellular membrane vesicles (EVs) offer promising values in various medical fields, e.g., as biomarkers in liquid biopsies or as native (or bioengineered) biological nanocarriers in tissue engineering, regenerative medicine and cancer t...