Susu Xiao,Min Mu,Chenqian Feng et al.
Susu Xiao et al.
Adverse effects and multidrug resistance remain significant obstacles in conventional cancer therapy. Nanomedicines, with their intrinsic properties such as nano-sized dimensions and tunable surface characteristics, have the potential to mi...
Ferroptosis-inducing nanomedicine and targeted short peptide for synergistic treatment of hepatocellular carcinoma [0.03%]
用于肝细胞癌协同治疗的促铁死亡纳米药物和靶向短肽
Luyang Wang,Le Tong,Zecheng Xiong et al.
Luyang Wang et al.
The poor prognosis of hepatocellular carcinoma (HCC) is still an urgent challenge to be solved worldwide. Hence, assembling drugs and targeted short peptides together to construct a novel medicine delivery strategy is crucial for targeted a...
Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells [0.03%]
纳米硅酸盐通过激活牙周膜细胞的PI3K-AKT信号通路促进牙周再生潜力
Ziqin Chen,Nianqi Xiao,Lan Luo et al.
Ziqin Chen et al.
The recent development of nanobiomaterials has shed some light on the field of periodontal tissue regeneration. Laponite (LAP), an artificially synthesized two-dimensional (2D) disk-shaped nanosilicate, has garnered substantial attention in...
Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing [0.03%]
用于糖尿病伤口管理的内源性电场耦合Mxene海绵：止血、抗菌和促进愈合
Hai Zhou,Lianglong Chen,Chaoyang Huang et al.
Hai Zhou et al.
Improper management of diabetic wound effusion and disruption of the endogenous electric field can lead to passive healing of damaged tissue, affecting the process of tissue cascade repair. This study developed an extracellular matrix spong...
Aminolysis-mediated single-step surface functionalization of poly (butyl cyanoacrylate) microbubbles for ultrasound molecular imaging [0.03%]
基于氨基醇解的单步表面修饰聚氰基丙烯酸丁酯微泡制备用于超声分子成像的靶向造影剂
Junlin Chen,Bi Wang,Anshuman Dasgupta et al.
Junlin Chen et al.
Molecular ultrasound imaging with actively targeted microbubbles (MB) proved promising in preclinical studies but its clinical translation is limited. To achieve this, it is essential that the actively targeted MB can be produced with high ...
Ultrasound targeted microbubble destruction assisted exosomal delivery of siHmox1 effectively inhibits doxorubicin-induced cardiomyocyte ferroptosis [0.03%]
超声微泡辅助溶酶体递送siHmox1有效抑制多柔比星致心肌细胞铁死亡
Jianmei Chen,Shuo Qiu,Yang Liu et al.
Jianmei Chen et al.
Ferroptosis, triggered by iron overload and excessive lipid peroxidation, plays a pivotal role in the progression of DOX-induced cardiomyopathy (DIC), and thus limits the use of doxorubicin (DOX) in clinic. Here, we further showed that card...
Temporal and spatial resolution of magnetosome degradation at the subcellular level in a 3D lung carcinoma model [0.03%]
三维肺癌模型中亚细胞水平磁小体降解的时间和空间分辨率
Alicia G Gubieda,Lucía Gandarias,Mihály Pósfai et al.
Alicia G Gubieda et al.
Magnetic nanoparticles offer many exciting possibilities in biomedicine, from cell imaging to cancer treatment. One of the currently researched nanoparticles are magnetosomes, magnetite nanoparticles of high chemical purity synthesized by m...
Multi-omics analysis of Au@Pt nanozyme for the modulation of glucose and lipid metabolism [0.03%]
基于Au@Pt纳米酶的糖脂代谢调控多组学研究
Yanan Wang,Qi Zhang,Minrui Kan et al.
Yanan Wang et al.
Au@Pt nanozyme, a bimetallic core-shell structure Au and Pt nanoparticle, has attracted significant attention due to its excellent catalytic activity and stability. Here, we propose that Au@Pt improves glucose tolerance and reduces TG after...
Macrophage-derived extracellular vesicles represent a promising endogenous iron-chelating therapy for iron overload and cardiac injury in myocardial infarction [0.03%]
巨噬细胞源外泌体代表了一种有前景的内源性铁螯合疗法，可治疗心肌梗死中铁过载和心脏损伤
Dong Guo,Xue Yang,Rui Yu et al.
Dong Guo et al.
Background: Cardiac iron overload and ferroptosis greatly contribute to the poor prognosis of myocardial infarction (MI). Iron chelator is one of the most promising strategies for scavenging excessive iron and alleviating...
Solid-state electron-mediated z-scheme heterostructured semiconductor nanomaterials induce dual programmed cell death for melanoma therapy [0.03%]
固态电子介导的z型半导体纳米材料诱导黑色素瘤治疗中的双重程序性细胞死亡
Yiping Ren,Yun Wang,Cheng Chen et al.
Yiping Ren et al.
The programmed cell death (PCD) pathway removes functionally insignificant, infection-prone, or potentially tumorigenic cells, underscoring its important role in maintaining the stability of the internal environment and warding off cancer a...