Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics [0.03%]
精准疾病治疗的个性化口服纳米防护益生菌方案探究
Anmei Chen,Ying Gong,Shaoquan Wu et al.
Anmei Chen et al.
Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a tran...
Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a "three birds with one stone" strategy [0.03%]
一种治疗类风湿性关节炎的“一石三鸟”策略：兼备双重靶向与智能响应的纳米药物递送体系
Rui-Bo Guo,Lu Zhang,Yang Liu et al.
Rui-Bo Guo et al.
Rheumatoid arthritis (RA) is an autoimmune disease whose pathophysiology is closely related to inflammation-associated cells and the microenvironment of inflamed joints. This study aimed to develop dual-targeted, reactive oxygen species (RO...
Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing [0.03%]
基于柠檬提取物的纳米颗粒功能化水凝胶调节巨噬细胞重编程以促进糖尿病伤口愈合
Enyou Jin,Yusheng Yang,Shengjie Cong et al.
Enyou Jin et al.
The orderly regulation of immune inflammation and promotion of the regeneration of skin vessels and fibers are key to the treatment of diabetic skin injury (DSI). Although various traditional polypeptide biological dressings continue to be ...
Nanocarriers boost non-systemic fluazinam transportation in plants and microbial community enrichment in soil [0.03%]
纳米载体增强植物中的非系统性氟苯脲运输和土壤中微生物群落的富集
Wenhui Xiao,Jiang Du,Yuxin Zheng et al.
Wenhui Xiao et al.
Utilizing nanotechnology for pesticide delivery can enhance their uptake and distribution in plants, thereby boosting pesticide efficiency. Fluazinam, a highly effective broad-spectrum fungicide with unique mode of action, is hindered by it...
Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis [0.03%]
Limosilactobacillus reuteri在急性实验性结肠炎缓解中的作用研究
Ningning Yue,Hailan Zhao,Peng Hu et al.
Ningning Yue et al.
Probiotics have been proposed as a potential strategy for managing ulcerative colitis (UC). However, the underlying mechanisms mediating microbiota-host crosstalk remain largely elusive. Here, we report that Limosilactobacillus reuteri (L. ...
A bibliometric analysis of hydrogel research in various fields: the trends and evolution of hydrogel application [0.03%]
多领域水凝胶研究的文献计量分析：水凝胶应用的发展与演变趋势分析
Zhong-Zhu Yuan,Yu-Zhou Fan,Shao-Jun Cheng et al.
Zhong-Zhu Yuan et al.
Hydrogel, a polymer material with a three-dimensional structure, has considerably expanded in research across multiple fields lately. However, the lack of a comprehensive review integrating the research status of hydrogel across diverse fie...
Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer [0.03%]
胰蛋白酶指导的活性肽纳米药物通过级联反应改善结肠癌化疗
Can Wu,Xiao Wei Zhang,Manman Wang et al.
Can Wu et al.
Chemotherapy remains an effective treatment for colon cancer but is hampered by its limited response rate. Bioactive peptides, marked with intracellular transformations, have been reported as an effective approach to boosting chemotherapeut...
Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair [0.03%]
局部给药的脂质体药物储库通过抑制炎症和促进软骨修复来增强类风湿性关节炎治疗
Zongquan Zhang,Guan Wang,Zhuo Zhang et al.
Zongquan Zhang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by synovial hyperplasia, where inflammatory macrophages within the joint synovium produce multiple inflammatory cytokines, leading to cartilage damage. The developmen...
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells [0.03%]
工程化细胞外囊泡表面整合素(ITGAL和ITGB2)以靶向ICAM-1表达的内皮细胞
Markus Bergqvist,Kyong-Su Park,Nasibeh Karimi et al.
Markus Bergqvist et al.
Extracellular vesicles (EVs) are taken up by most cells, however specific or preferential cell targeting remains a hurdle. This study aims to develop an EV that targets cells involved in inflammation, specifically those expressing intercell...
Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles [0.03%]
一种用于通过水凝胶微针协同治疗白癜风的模拟多巴胺载有jak抑制剂疗法
Chunying Li,Wenwen Wang,Junyi Shao et al.
Chunying Li et al.
Background: Both oxidative stress and autoimmune responses play crucial roles in the development of vitiligo. Under oxidative stress, the apoptotic melanocytes expose self-antigens and release high mobility group box 1 (H...