Apoptotic vesicles (apoVs) derived from fibroblast-converted hepatocyte-like cells effectively ameliorate liver fibrosis [0.03%]
由成纤维细胞转化的肝细胞样细胞来源的凋亡小体有效改善肝纤维化
Zhi Zhong,Xiu-Liang Cui,Kun-Jiang Tan et al.
Zhi Zhong et al.
Liver fibrosis is a serious global health issue for which effective treatment remains elusive. Chemical-induced hepatocyte-like cells (ciHeps) have emerged as an appealing source for cell transplantation therapy, although they present sever...
Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway [0.03%]
超声波触发压电聚醚醚酮促进骨发生的作用及机制研究
Yue Li,Yingying Fan,Siyu Zhao et al.
Yue Li et al.
Maxillofacial bone defects can severely impact quality of life by impairing physiological functions such as chewing, breathing, swallowing, and pronunciation. Polyether ether ketone (PEEK) is commonly used for the repair of maxillofacial de...
Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis [0.03%]
TCOF1/FLVCR1介导的线粒体稳态调节物可缓解衰老相关骨老化表型
Yan Qu,Bowen Meng,Simin Cai et al.
Yan Qu et al.
Over 50 billion cells undergo apoptosis each day in an adult human to maintain tissue homeostasis by eliminating damaged or unwanted cells. Apoptotic deficiency can lead to age-related diseases with reduced apoptotic metabolites. However, w...
Nanoparticle LDH enhances RNAi efficiency of dsRNA in piercing-sucking pests by promoting dsRNA stability and transport in plants [0.03%]
纳米LDH促进植物介导双链rna的稳定性及传输从而提高刺吸式害虫的RNA干扰效率
Xiaoqin Cheng,Qi Zhou,Jiedan Xiao et al.
Xiaoqin Cheng et al.
Piercing-sucking pests are the most notorious group of pests for global agriculture. RNAi-mediated crop protection by foliar application is a promising approach in field trials. However, the effect of this approach on piercing-sucking pests...
Enhanced osteogenic differentiation in 3D hydrogel scaffold via macrophage mitochondrial transfer [0.03%]
巨噬细胞线粒体转移促进三维水凝胶支架中的成骨分化
Shui Qiu,Lili Cao,Dingding Xiang et al.
Shui Qiu et al.
To assess the efficacy of a novel 3D biomimetic hydrogel scaffold with immunomodulatory properties in promoting fracture healing. Immunomodulatory scaffolds were used in cell experiments, osteotomy mice treatment, and single-cell transcript...
Apoptosis and cuproptosis Co-activated Copper-based metal-organic frameworks for cancer therapy [0.03%]
用于癌症治疗的凋亡和铜依赖性细胞死亡共激活的铜基金属有机框架
Kun Li,Leilei Wu,Han Wang et al.
Kun Li et al.
Lung cancer, predominantly non-small cell lung cancer (NSCLC), remains a significant global health challenge, with limited therapeutic options for patients with KRAS-mutated tumors. Herein, a copper-based metal-organic framework (Cu-MOF) wa...
A carbon dot nanozyme hydrogel enhances pulp regeneration activity by regulating oxidative stress in dental pulpitis [0.03%]
一种碳点纳米酶水凝胶通过调节牙髓炎中的氧化应激增强牙髓再生活性
Yingjuan Zhang,Xianxian Huang,Yicai Luo et al.
Yingjuan Zhang et al.
Preserving pulp viability and promoting pulp regeneration in pulpitis have attracted widespread attention. Restricted by the oxidative stress microenvironment of dental pulpitis, excessive reactive oxygen and nitrogen species (RONS) trigger...
Berberine and magnolol exert cooperative effects on ulcerative colitis in mice by self-assembling into carrier-free nanostructures [0.03%]
小分子自组装纳米结构协同治疗结肠炎研究
Yida Xu,Zhejie Chen,Wei Hao et al.
Yida Xu et al.
The risk of ulcerative colitis (UC) is increasing worldwide with limited success using classical drugs, which has underscored the development of novel agents. Recently, carrier-free molecular assembly has been proven to be an effective drug...
MiR-100-5p-rich small extracellular vesicles from activated neuron to aggravate microglial activation and neuronal activity after stroke [0.03%]
富集miR-100-5p的小细胞外囊泡通过活化神经元加剧卒中后的小胶质细胞活化和神经元活性
Danqing Xin,Tingting Li,Yijing Zhao et al.
Danqing Xin et al.
Ischemic stroke is a common cause of mortality and severe disability in human and currently lacks effective treatment. Neuronal activation and neuroinflammation are the major two causes of neuronal damage. However, little is known about the...
Tumor microenvironment-responsive manganese-based nano-modulator activate the cGAS-STING pathway to enhance innate immune system response [0.03%]
肿瘤微环境响应型锰基纳米调控剂激活cGAS-STING通路以增强先天免疫系统应答
Xiayi Liang,Duo Wang,Yuanquan Zhao et al.
Xiayi Liang et al.
Background: Manganese ions (Mn2+) combined with adjuvants capable of damaging and lysing tumor cells form an antitumor nano-modulator that enhances the immune efficacy of cancer therapy through the cascade activation of t...