Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis [0.03%]
TNF-α预处理的IPFP-MSCs来源的工程外泌体可提高骨关节炎治疗效果及分泌量
Jiangyi Wu,Jinhui Wu,Wei Xiang et al.
Jiangyi Wu et al.
Background: The pathogenesis of osteoarthritis (OA) involves the progressive degradation of articular cartilage. Exosomes derived from mesenchymal stem cells (MSC-EXOs) have been shown to mitigate joint pathological injur...
Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA [0.03%]
脂质纳米颗粒(LNPs)大小、表面电荷和PEG化脂质对肌肉内递送mRNA的影响
Weiwen Kong,Yuning Wei,Zirong Dong et al.
Weiwen Kong et al.
Lipid nanoparticles (LNPs) are currently the most commonly used non-viral gene delivery system. Their physiochemical attributes, encompassing size, charge and surface modifications, significantly affect their behaviors both in vivo and in v...
Non-viral approaches in CAR-NK cell engineering: connecting natural killer cell biology and gene delivery [0.03%]
非病毒型CAR-NK细胞工程方法：衔接自然杀伤细胞生物学与基因传递
Emma M McErlean,Helen O McCarthy
Emma M McErlean
Natural Killer (NK) cells are exciting candidates for cancer immunotherapy with potent innate cytotoxicity and distinct advantages over T cells for Chimeric Antigen Receptor (CAR) therapy. Concerns regarding the safety, cost, and scalabilit...
Rationally designed catalytic nanoplatform for enhanced chemoimmunotherapy via deploying endogenous plus exogenous copper and remodeling tumor microenvironment [0.03%]
通过部署内源性加上外源性铜和重塑肿瘤微环境来增强化学免疫治疗的合理设计催化纳米平台
Daxi Sun,Liting Yu,Gang Wang et al.
Daxi Sun et al.
Chemodynamic therapy represents a novel tumor therapeutic modality via triggering catalytic reactions in tumors to yield highly toxic reactive oxygen species (ROS). Nevertheless, low efficiency catalytic ability, potential systemic toxicity...
GelMA loaded with exosomes from human minor salivary gland organoids enhances wound healing by inducing macrophage polarization [0.03%]
人源小唾液腺类器官衍生的外泌体修饰明胶美得舒水凝胶通过诱导巨噬细胞极化促进伤口愈合
Jiaying Qian,Enhang Lu,Haibo Xiang et al.
Jiaying Qian et al.
Non-healing skin wounds pose significant clinical challenges, with biologic products like exosomes showing promise for wound healing. Saliva and saliva-derived exosomes, known to accelerate wound repair, yet their extraction is difficult du...
A nanoscale visual exploration of the pathogenic effects of bacterial extracellular vesicles on host cells [0.03%]
细菌外泌体感染宿主细胞致病性的纳米视觉探索
Minjae Kang,Min Jeong Kim,Dokyung Jeong et al.
Minjae Kang et al.
Background: Bacterial extracellular vesicles (EVs) are pivotal mediators of intercellular communication and influence host cell biology, thereby contributing to the pathogenesis of infections. Despite their significance, ...
Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis [0.03%]
透明质酸包被的聚肽纳米凝胶增强Tacrolimus治疗类风湿性关节炎的靶向分布与疗效研究
Yuhuan Li,Xin Wang,Yu Gao et al.
Yuhuan Li et al.
Rheumatoid arthritis (RA) involves chronic inflammation, oxidative stress, and complex immune cell interactions, leading to joint destruction. Traditional treatments are often limited by off-target effects and systemic toxicity. This study ...
GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor [0.03%]
一种基于PD-1抑制的增效光免疫疗法协同响应型聚合物胶束化制剂，用于激发强烈抗结肠肿瘤免疫力
Chenlu Huang,Xinyu Yang,Huidong Li et al.
Chenlu Huang et al.
Phototherapy is a promising antitumor modality, which consists of photothermal therapy (PTT) and photodynamic therapy (PDT). However, the efficacy of phototherapy is dramatically hampered by local hypoxia in tumors, overexpression of indole...
Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis [0.03%]
用于改善溃疡性结肠炎的肠道平衡的口服仿生金属酚纳米酶具有四重保障
Yuanyuan Zhu,Xiaoling Huang,Zhichao Deng et al.
Yuanyuan Zhu et al.
Background: Ulcerative colitis (UC) is defined by persistent inflammatory processes within the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in their ability to address oxidative...
Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics [0.03%]
年轻的小细胞外囊泡通过重塑Drp1易位介导的线粒体动力学来逆转复制性衰老
Yingying Peng,Tingting Zhao,Shuxuan Rong et al.
Yingying Peng et al.
Background: Human mesenchymal stem cells have attracted interest in regenerative medicine and are being tested in many clinical trials. In vitro expansion is necessary to provide clinical-grade quantities of mesenchymal s...