A mucoadhesive-to-penetrating nanomotors-in-hydrogel system for urothelium-oriented intravesical drug delivery [0.03%]
一种用于尿路上药的粘附渗透性纳米马达-水凝胶系统
Bin Zheng,Haibao Zhang,Jinxue Wang et al.
Bin Zheng et al.
Intravesical therapy (IT) is widely used to tackle various urological diseases. However, its clinical efficacy is decreased by the impermeability of various barriers presented on the bladder luminal surface, including the urinary mucus laye...
Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis [0.03%]
重组铁蛋白基纳米颗粒作为neo抗原载体显著抑制肿瘤生长和转移
Wei Zheng,Shixiong Li,Zhongliang Shi et al.
Wei Zheng et al.
Background: Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a va...
Circ_0001947 encapsulated by small extracellular vesicles promotes gastric cancer progression and anti-PD-1 resistance by modulating CD8+ T cell exhaustion [0.03%]
小细胞外囊泡封装的环状circ_0001947通过调节CD8⁺T细胞衰竭促进胃癌进展和抗PD-1耐药性
Bingyu Wang,Wenbo Liu,Mingming Zhang et al.
Bingyu Wang et al.
Background: While small extracellular vesicles (sEVs)-derived circular RNAs (circRNAs) have been emerged as significant players in cancer, the function and underlying mechanism of sEVs-derived circRNAs in anti-cancer immu...
Multi-therapeutic-activity selenium nanodot toward preventing brain injury and restoring neurobehavioral functions following hemorrhagic stroke [0.03%]
预防出血性中风后的脑损伤和恢复神经行为功能的多效活性硒纳米点
Yibin Zhang,Xiaoyu Wang,Xuegang Niu et al.
Yibin Zhang et al.
Intracerebral hemorrhage is a lethal cerebrovascular disease, and the inevitable secondary brain injury (SBI) is responsible for serious disability and death. Perfect therapeutic goal is to minimize SBI and restore neurobehavioral functions...
Seed priming with graphene oxide improves salinity tolerance and increases productivity of peanut through modulating multiple physiological processes [0.03%]
石墨烯氧化物种子处理通过调节多种生理过程提高盐渍条件下花生的耐盐性和产量潜力
Ning Yan,Junfeng Cao,Jie Wang et al.
Ning Yan et al.
Graphene oxide (GO), beyond its specialized industrial applications, is rapidly gaining prominence as a nanomaterial for modern agriculture. However, its specific effects on seed priming for salinity tolerance and yield formation in crops r...
A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs [0.03%]
一种新型球形GelMA-HAMA水凝胶，内含APET×2多肽和CFIm25靶向sgRNA，用于调制免疫微环境和椎间盘髓核再生
Xiao-Jun Yu,Yuan-Ting Zhao,Haimiti Abudouaini et al.
Xiao-Jun Yu et al.
Methods: Single-cell transcriptomics and high-throughput transcriptomics were used to screen factors significantly correlated with intervertebral disc degeneration (IDD). Expression changes of CFIm25 were determined via R...
Preparation and effects of functionalized liposomes targeting breast cancer tumors using chemotherapy, phototherapy, and immunotherapy [0.03%]
用于乳腺癌肿瘤的化疗、光动力治疗和免疫治疗的功能化脂质体的制备及其效果研究
Bowen Zeng,Lina Pian,Yanhong Liu et al.
Bowen Zeng et al.
Breast cancer therapy has significantly advanced by targeting the programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway. BMS-202 (a smallmolecule PD-L1 inhibitor) induces PD-L1 dimerization to block PD-1/PD-L1 interact...
ACYP2 functions as an innovative nano-therapeutic target to impede the progression of hepatocellular carcinoma by inhibiting the activity of TERT and the KCNN4/ERK pathway [0.03%]
ACYP2作为抗肝癌纳米治疗靶点通过抑制TERT活性及KCNN4/ERK通路发挥抑瘤作用
Yixuan Wu,Hongyi Bao,Jinran Wu et al.
Yixuan Wu et al.
An increasing body of evidence suggests that acylphosphatase-2 (ACYP2) polymorphisms are correlated with an increased susceptibility to a range of malignancies. Nevertheless, its potential functions, molecular mechanisms in hepatocellular c...
Fei Guo,Yizhan Wu,Jiangwei Liu
Fei Guo
Objective: The exacerbation of extreme high-temperature events due to global climate change poses a significant challenge to public health, particularly impacting the central nervous system through heat stroke. This study...
Ellagic acid-enhanced biocompatibility and bioactivity in multilayer core-shell gold nanoparticles for ameliorating myocardial infarction injury [0.03%]
ellagic酸增强的多层核壳型金纳米颗粒的生物相容性和生物活性可改善心肌梗死损伤
Xina Yu,Jie Wang,Tiantian Wang et al.
Xina Yu et al.
Background: Myocardial infarction (MI) is the main contributor to most cardiovascular diseases (CVDs), and the available post-treatment clinical therapeutic options are limited. The development of nanoscale drug delivery ...