Magnesium metal-organic framework microneedles loaded with curcumin for accelerating oral ulcer healing [0.03%]
负载有姜黄素的镁金属有机骨架微针促进口腔溃疡修复
Junhui Liu,Zhipeng Zhang,Xiufei Lin et al.
Junhui Liu et al.
Oral ulcers are a common oral mucosal disease that seriously affect the quality of life. Traditional drug treatments have shown unsatisfactory efficacy and potential adverse reactions. In this study, curcumin-loaded multifunctional magnesiu...
A metal-organic nanoframework for efficient colorectal cancer immunotherapy by the cGAS-STING pathway activation and immune checkpoint blockade [0.03%]
一种金属有机纳米框架通过活化cGAS-STING途径和免疫检查点阻断进行高效的结直肠癌免疫治疗
Xiaodian Zhang,Hailong Tian,Yang Chen et al.
Xiaodian Zhang et al.
Immunotherapy has shown marked progress in promoting systemic anti-colorectal cancer (CRC) clinical effects. For further effectively sensitizing CRC to immunotherapy, we have engineered a pH-sensitive zeolitic imidazolate framework-8 (CS/NP...
Enzyme-armed nanocleaner provides superior detoxification against organophosphorus compounds via a dual-action mechanism [0.03%]
双管齐下机制使纳米清洁剂在酶的作用下高效降解有机磷化合物中毒素
Kang Qin,Fei Meng,Dianpeng Han et al.
Kang Qin et al.
By inhibiting acetylcholinesterase (AChE) activity, organophosphate compounds (OPs) can quickly cause severe injury to the nervous system and death, making it extremely difficult to rescue victims after OP exposure. However, it is quite cha...
Multiparametric profiling of HER2-enriched extracellular vesicles in breast cancer using Single Extracellular VEsicle Nanoscopy [0.03%]
基于单个细胞外囊泡纳米显微镜的乳腺癌HER2富集型细胞外囊泡多参数谱分析
Nan Jiang,Andras Saftics,Eugenia Romano et al.
Nan Jiang et al.
Background: Patients with HER2-positive breast cancer can significantly benefit from HER2-directed therapy - such as the monoclonal antibody trastuzumab. However, some patients can develop therapy resistance or change HER...
Lymph node metastasis diagnosis of postoperative OSCC patients by analyzing extracellular vesicles in drainage fluid based on microfluidic isolation [0.03%]
基于微流控隔离技术分析引流液中细胞外囊泡诊断术后OSCC患者淋巴结转移性病变
Zi-Zhan Li,Ze-Min Cai,Wen-Tao Zhu et al.
Zi-Zhan Li et al.
Lymph node metastasis (LNM) is a typical marker in oral squamous cell carcinoma (OSCC) indicating poor prognosis. Pathological examination by artificial image acquisition and analysis, as the main diagnostic method for LNM, often takes a we...
Leveraging adrenergic receptor blockade for enhanced nonalcoholic fatty liver disease treatment via a biomimetic nanoplatform [0.03%]
利用类生物学纳米平台阻断肾上腺素受体治疗非酒精性脂肪肝病的研究
Bingyuan Fei,Yuewu Zhao,Jine Wang et al.
Bingyuan Fei et al.
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation, steatosis and fibrosis. Sympathetic nerves play a critical role in maintaining hepatic lipid homeostasis and regulating fibrotic progression through ...
Responsive porous microneedles with riboflavin ocular microinjection capability for facilitating corneal crosslinking [0.03%]
一种具有核黄素眼部微量注射能力的可变形多孔微针用于促进角膜交联
Xiaojun Hu,Bin Kong,Yunzhe Wang et al.
Xiaojun Hu et al.
Riboflavin-5-phosphate (riboflavin) is the most commonly used photosensitizer in corneal crosslinking (CXL); while its efficient delivery into the stroma through the corneal epithelial barrier is challenging. In this paper, we presented nov...
miR-NPs-RVG promote spinal cord injury repair: implications from spinal cord-derived microvascular endothelial cells [0.03%]
miR-NPs-RVG促进脊髓损伤修复：源自脊髓的微血管内皮细胞的启示
Chao Li,Zhenyang Xiang,Mengfan Hou et al.
Chao Li et al.
Background: Spinal cord injury (SCI) often leads to a loss of motor and sensory function. Axon regeneration and outgrowth are key events for functional recovery after spinal cord injury. Endogenous growth of axons is asso...
Photoactive nanocatalysts as DTT-assisted BSA-AuNCs with enhanced oxidase-mimicking ability for sensitive fluorometric detection of antioxidants [0.03%]
一种基于DTT辅助的BSA-AuNCs纳米催化剂的模拟氧化酶在荧光检测抗氧化剂中的应用研究
Sanskruti Swain,Ting-Yi Lin,I-Hsuan Chou et al.
Sanskruti Swain et al.
Redox imbalance and oxidative stress are increasingly recognized as significant factors in health disorders such as neurodegenerative disorders, premature aging and cancer. However, detecting antioxidant levels that is crucial for managing ...
Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review [0.03%]
用于抗癌药物输送的红氧操纵纳米载体：系统性综述
Xuan Meng,Yongli Shen,Huanyu Zhao et al.
Xuan Meng et al.
Spatiotemporally controlled cargo release is a key advantage of nanocarriers in anti-tumor therapy. Various external or internal stimuli-responsive nanomedicines have been reported for their ability to increase drug levels at the diseased s...