Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy [0.03%]
黄酮茋IV负载的生物模拟纳米颗粒通过靶向IκBα调节中性粒细胞外陷阱形成以用于脓毒症治疗
Shujuan Wu,Mengqi Zhou,Huimin Zhou et al.
Shujuan Wu et al.
This study explored the novel mechanism of Astragaloside IV (As) in treating sepsis and its application through a biomimetic nano-delivery system (As@ZM). Sepsis, a condition of organ dysfunction caused by an abnormal host response to infec...
pH-responsive cationic polymer-functionalized poly-ε-caprolactone microspheres scavenge cell-free-DNA to alleviate intestinal ischemia/reperfusion injury by inhibiting M1 macrophage polarization [0.03%]
pH响应的阳离子聚合物功能化的聚-ε-己内酯微球通过抑制M1型巨噬细胞极化来清除无细胞DNA从而减轻肠道缺血再灌注损伤
Hanbin Xie,Cong Wei,Chang Xiong et al.
Hanbin Xie et al.
Intestinal ischemia/reperfusion (I/R) injury is a common life-threatening condition. Inflammatory dysregulation plays a crucial role in the pathological progression of intestinal I/R injury, indicating that controlling excessive inflammator...
Black phosphorus nanosheets encapsulated microneedle for multifunctional therapy for androgenic alopecia [0.03%]
用于多功能治疗雄性脱发的封装黑磷纳米片微针
Sha Xiong,Zhongjun Li,Siwen Jiao et al.
Sha Xiong et al.
Background: Androgenetic alopecia (AGA), a chronic and progressive disease, significantly impacts the patients' social, emotional, and mental well-being. Current treatment for AGA are mainly limited by drug side effects a...
A self-adjuvant multiantigenic nanovaccines simultaneously activate the antiviral and antitumor immunity for the treatment of cancers [0.03%]
一种自我辅助的多抗原纳米疫苗可同时激活抗病毒和抗癌免疫以治疗癌症
Zhongjie Wang,Hanlin Chen,Ruiqi Ming et al.
Zhongjie Wang et al.
Background: Tumor cell-derived extracellular vesicles (tEVs) have garnered significant attention as promising antigen delivery vehicles for the development of cancer vaccines. However, their practical applications are hin...
Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury [0.03%]
PV-K纳米设备促进NLRP3自噬溶酶体降解以防止巨噬细胞焦亡介导的肺损伤
Yan Fan,Jian Mei,Yuehao Shen et al.
Yan Fan et al.
Acute respiratory distress syndrome (ARDS) has emerged as a significant global health challenge, with no definitive curative treatment available. Recent evidence suggests that pyroptosis of immune cells plays a pivotal role in the pathogene...
Polydopamine-based nano-protectant for prolonged boar semen preservation by eliminating ROS and regulating protein phosphorylation via D2DR-mediated cAMP/PKA signaling pathway [0.03%]
基于聚多巴胺的纳米保护剂通过消除ROS和调控cAMP/PKA信号通路介导的蛋白磷酸化实现延长公猪精液保存期限
Lirui Wang,Manyi Xiong,Jian Zhang et al.
Lirui Wang et al.
Preservation of porcine semen is essential for artificial insemination and genetic improvement in pig breeding programs. However, the overproduction of reactive oxygen species (ROS) and lower levels of protein phosphorylation emerge as two ...
Correction: Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy [0.03%]
校正：冷暴露诱导的血浆外泌体通过抑制自噬影响骨质
Li-Min Lei,Fu-Xing-Zi Li,Xiao Lin et al.
Li-Min Lei et al.
Published Erratum
Journal of nanobiotechnology. 2025 Feb 28;23(1):154. DOI:10.1186/s12951-025-03130-6 2025
AG73-GelMA/AlgMA hydrogels provide a stable microenvironment for the generation of pancreatic progenitor organoids [0.03%]
AG73-GelMA/AlgMA水凝胶为胰腺祖细胞类器官的形成提供了稳定的微环境
Jian Wan,Yang Xu,Tianmu Qi et al.
Jian Wan et al.
Patient specific induced pluripotent stem cells (iPSCs) derived β cells represent an effective means for disease modeling and autologous diabetes cell replacement therapy. In this study, an AG73-5%gelatin methacryloyl (GelMA) /2% alginate ...
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury [0.03%]
果胶-清蛋白-IPA纳米颗粒促进脊髓损伤后的功能恢复并减轻神经炎症
Xianghang Chen,Beini Wang,Abdullah Al Mamun et al.
Xianghang Chen et al.
Introduction: Spinal cord injury (SCI) impairs the balance of gut microbiomes, which further aggravates inflammation in the injured areas and inhibits axonal regeneration. The intestinal microbiome plays an important role...
The blood-brain barriers: novel nanocarriers for central nervous system diseases [0.03%]
血脑屏障：中枢神经系统疾病新型纳米载体
Jiajun Liu,Ting Wang,Jian Dong et al.
Jiajun Liu et al.
The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood-brain barrier (BBB) often prevents drugs intended for CNS diseases from effectively crossing into the brain parenchyma to...