Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy [0.03%]
肿瘤特异性原位合成治疗药物的精准癌症治疗方法
Zhixin Zhou,Cheng Zhou,Jia Liu et al.
Zhixin Zhou et al.
Background: Traditional chemotherapeutic agents suffer from a lack of selectivity, poor targeting ability, and drug resistance. Developing tumor-specific therapies is crucial for precisely eliminating tumors while circumv...
US/PA/MR multimodal imaging-guided multifunctional genetically engineered bio-targeted synergistic agent for tumor therapy [0.03%]
用于肿瘤治疗的美国/_pa/mr多模影像引导多功能基因工程化生物靶向协同药物
Li Ren,Yaotai Wang,Yu Tang et al.
Li Ren et al.
Focused ultrasound ablation surgery (FUAS) is a minimally invasive treatment option that has been utilized in various tumors. However, its clinical advancement has been hindered by issues such as low safety and efficiency, single image guid...
Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression [0.03%]
甘露糖修饰的硒纳米颗粒通过抑制NF-κB活化和增强谷胱甘肽过氧化物酶表达来调节小鼠肠道稳态并缓解结肠炎
Hui Yang,Zhiyao Wang,Lixin Li et al.
Hui Yang et al.
Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonstrate potential anti-inflammatory and anti-oxidative properties. However, most lectin receptors bind ...
Haozhou Tang,Dan Yu,Jiahui Zhang et al.
Haozhou Tang et al.
Liquid biopsy is a minimally invasive method that uses biofluid samples instead of tissue samples for cancer diagnosis. Exosomes are small extracellular vesicles secreted by donor cells and act as mediators of intercellular communication in...
Zinc-based Polyoxometalate Nanozyme Functionalized Hydrogels for optimizing the Hyperglycemic-Immune Microenvironment to Promote Diabetic Wound Regeneration [0.03%]
一种锌基多金属氧酸盐纳米酶功能水凝胶，用于优化高糖免疫微环境以促进糖尿病伤口再生
Chaoyu Pu,Yong Wang,Honglin Xiang et al.
Chaoyu Pu et al.
Background: In diabetic wounds, hyperglycemia-induced cytotoxicity and impaired immune microenvironment plasticity directly hinder the wound healing process. Regulation of the hyperglycemic microenvironment and remodeling...
Double-camouflaged tellurium nanoparticles for enhanced photothermal immunotherapy of tumor [0.03%]
用于增强肿瘤光热免疫治疗的双重伪装的碲纳米粒子
Chaoqing Li,Luyao Yang,Bin Zhang et al.
Chaoqing Li et al.
The photothermal conversion properties of tellurium (Te) nanoparticles have been extensively investigated, rendering them a promising candidate for tumor photothermal therapy. However, there is still room for improvement in the development ...
Nanomaterial-mediated host directed therapy of tuberculosis by manipulating macrophage autophagy [0.03%]
纳米材料介导的宿主导向结核病治疗及其对巨噬细胞自噬的调控作用研究
Yilin Liu,Jiajun Wang,Jiayi Yang et al.
Yilin Liu et al.
Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a major public health issue worldwide. Mtb has developed complicated strategies to inhibit the immunological clearance of host cells, which significantly prom...
Shiqi Han,Jianhua Zou,Fan Xiao et al.
Shiqi Han et al.
Ferroptosis, distinct from apoptosis, necrosis, and autophagy, is a unique type of cell death driven by iron-dependent phospholipid peroxidation. Since ferroptosis was defined in 2012, it has received widespread attention from researchers w...
Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice [0.03%]
口服给药飞燕草衍生的携带CX5461的类外泌体纳米囊泡可改善小鼠DSS诱导结肠炎
Manqi Zhang,Xichao Xu,Liqian Su et al.
Manqi Zhang et al.
Ulcerative colitis (UC) belongs to chronic inflammatory disease with a relapsing characterization. Conventional oral drugs of UC are restricted in clinical by premature degradation in the gastrointestinal tract, modest efficacy, and adverse...
Ultrasound-responsive nanocarriers with siRNA and Fe3O4 regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy [0.03%]
负载siRNA和Fe3O4的响应型纳米载体调节巨噬细胞极化及吞噬作用以增强非小细胞肺癌免疫治疗
Ming Li,Yuanyuan Li,Jun Zheng et al.
Ming Li et al.
The immunosuppressive tumor microenvironment (TME) significantly inhibits the effective anti-tumor immune response, greatly affecting the efficacy of immunotherapy. Most tumor-associated macrophages (TAMs) belong to the M2 phenotype, which ...