Brain-targeted ursolic acid nanoparticles for anti-ferroptosis therapy in subarachnoid hemorrhage [0.03%]
针对蛛网膜下腔出血的抗铁死亡脑靶向乌索酸纳米粒子治疗
Yong Li,Xinyi Zhu,Wei Xiong et al.
Yong Li et al.
Background: Subarachnoid hemorrhage (SAH) is a life -threatening cerebrovascular disease, where early brain injury (EBI) stands as a primary contributor to mortality and unfavorable patient outcomes. Neuronal ferroptosis ...
Novel combination therapy using recombinant oncolytic adenovirus silk hydrogel and PD-L1 inhibitor for bladder cancer treatment [0.03%]
基于重组肿瘤选择性腺病毒和PD-L1抗体的膀胱癌新型综合疗法研究及应用评估 silk 羟乙基甲基纤维素交联水凝胶为载体
Wenqiang Zhang,Jianqiang Zhang,Jingwei Zhang et al.
Wenqiang Zhang et al.
Recombinant oncolytic adenovirus offers a novel and promising cancer treatment approach, but its standalone efficacy remains limited. This study investigates a combination treatment strategy by co-administering recombinant oncolytic Adv-loa...
Stable triangle: nanomedicine-based synergistic application of phototherapy and immunotherapy for tumor treatment [0.03%]
稳定的三角形：基于纳米医学的光免疫协同治疗肿瘤研究
Wenjing Cai,Tuyue Sun,Chenyu Qiu et al.
Wenjing Cai et al.
In recent decades, cancer has posed a challenging obstacle that humans strive to overcome. While phototherapy and immunotherapy are two emerging therapies compared to traditional methods, they each have their advantages and limitations. The...
Unlocking nature's brilliance: using Antarctic extremophile Shewanella baltica to biosynthesize lanthanide-containing nanoparticles with optical up-conversion [0.03%]
利用南极极端环境中的嗜极菌舍温和细菌合成含镧系元素的上转换荧光纳米粒子
Nia Oetiker,Juan José León,Mark Swihart et al.
Nia Oetiker et al.
Both lanthanide-containing and fluorine-containing nanomaterials present challenging targets for microbial biosynthesis because these elements are toxic to most bacteria. Here, we overcome these challenges by using an Antarctic Shewanella b...
Layer by layer self-assembled hyaluronic acid nanoarmor for the treatment of ulcerative colitis [0.03%]
分层自组装透明质酸纳米甲胄治疗溃疡性结肠炎
Xinxin Zhao,Yuchen Zhang,Pengchong Wang et al.
Xinxin Zhao et al.
Natural compound-based treatments provide innovative ways for ulcerative colitis therapy. However, poor targeting and rapid degradation curtail its application, which needs to be addressed. Inspired by biomacromolecule-based materials, we h...
Highly integrated, self-powered and activatable bipedal DNA nanowalker for imaging of base excision repair in living cells [0.03%]
一种用于活细胞中碱基切除修复成像的高度集成的、自驱动和可激活的DNA纳米行走器
Rongji Lai,Xianghe Pan,Yingfeng Qin et al.
Rongji Lai et al.
DNA walkers have attracted considerable attention in biosensing and bioimaging. Compared with the conventional single leg-based DNA walker, the bipedal DNA walker has remarkable advantages, with improved sensitivity and fast kinetics, and c...
Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells [0.03%]
硒纳米颗粒通过恢复GPX1介导的氧化还原平衡和髓核细胞线粒体功能来改善腰椎间盘退变
Wei He,Xin Tian,Quan Zhou et al.
Wei He et al.
Intervertebral disc degeneration (IVDD) is a prevalent musculoskeletal disorder that involves the excessive accumulation of reactive oxygen species (ROS), resulting in mitochondrial dysfunction and matrix metabolism imbalance in nucleus pul...
Metal-organic-framework-based sitagliptin-release platform for multieffective radiation-induced intestinal injury targeting therapy and intestinal flora protective capabilities [0.03%]
基于金属有机骨架的西他列汀递送平台在多效放射引起的小肠损伤修复治疗及保护肠道菌群中的应用研究
Dan He,ZhiHui Li,Min Wang et al.
Dan He et al.
In patients with abdominal or pelvic tumors, radiotherapy can result in radiation-induced intestinal injury (RIII), a potentially severe complication for which there are few effective therapeutic options. Sitagliptin (SI) is an oral hypogly...
Neutrophil N1 polarization induced by cardiomyocyte-derived extracellular vesicle miR-9-5p aggravates myocardial ischemia/reperfusion injury [0.03%]
心肌细胞来源的外泌体miR-9-5p诱导中性粒细胞N1极化加重心肌缺血再灌注损伤
Yeshen Zhang,Xinzhong Li,Yining Dai et al.
Yeshen Zhang et al.
Neutrophil polarization contributes to inflammation and its resolution, but the role of neutrophil polarization in myocardial ischemia/reperfusion (I/R) injury remains unknown. Cardiomyocytes (CMs) participate in cardiac inflammation by sec...
Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy [0.03%]
光热Fe3O4纳米粒子诱导免疫原性铁死亡用于协同结直肠癌治疗
Yue Li,Jia Chen,Qi Xia et al.
Yue Li et al.
Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the imm...