GHRH-stimulated pituitary small extracellular vesicles inhibit hepatocyte proliferation and IGF-1 expression by its cargo miR-375-3p [0.03%]
生长激素释放激素刺激的垂体小细胞外囊泡通过其携带的miR-375-3p抑制肝细胞增殖和胰岛素样生长因子1表达
Jiali Xiong,Yuxuan Wang,Hailong Wang et al.
Jiali Xiong et al.
Small extracellular vesicles (sEV) have emerged as a novel mode of intercellular material transport and information transmission. It has been suggested hormones may regulate the production and function of sEV. However, the specific impact o...
Exosomal miR-1a-3p derived from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of BMSCs in glucocorticoid-associated osteonecrosis of the femoral head by targeting Cebpz [0.03%]
糖皮质激素刺激的M1型巨噬细胞来源的外泌体miR-1a-3p通过靶向Cebpz促进骨髓间充质干细胞向脂肪分化从而参与股骨头坏死发病机制
Ping Duan,Yong-Le Yu,Yan-Nan Cheng et al.
Ping Duan et al.
Background: By interacting with bone marrow mesenchymal stem cells (BMSCs) and regulating their function through exosomes, bone macrophages play crucial roles in various bone-related diseases. Research has highlighted a n...
Co-delivery of polyphyllin II and IR780 PLGA nanoparticles induced pyroptosis combined with photothermal to enhance hepatocellular carcinoma immunotherapy [0.03%]
共递送鬼臼毒素Ⅱ和IR780聚乳酸羟基乙酸纳米颗粒诱导细胞焦亡联合光热疗法增强肝癌免疫治疗
Huating Huang,Jing Fu,Hulinyue Peng et al.
Huating Huang et al.
The clinical efficacy of immunotherapy for hepatocellular carcinoma (HCC) is significantly limited by the low immunogenicity of the tumor. Recent studies have revealed that both pyroptosis and photothermal therapy can effectively induce tum...
Alleviating rheumatoid arthritis with a photo-pharmacotherapeutic glycan-integrated nanogel complex for advanced percutaneous delivery [0.03%]
一种用于透皮递送的光控给药糖基化纳米凝胶复合物缓解类风湿性关节炎
Pei-Wei Weng,Hsien-Tsung Lu,Lekshmi Rethi et al.
Pei-Wei Weng et al.
The prospective of percutaneous drug delivery (PDD) mechanisms to address the limitations of oral and injectable treatment for rheumatoid arthritis (RA) is increasing. These limitations encompass inadequate compliance among patients and acu...
Single-atom nanozyme liposome-integrated microneedles for in situ drug delivery and anti-inflammatory therapy in Parkinson's disease [0.03%]
用于帕金森病原位药物输送和抗炎疗法的单原子纳米酶脂质体集成微针
Ying Liu,Ye Liu,Peimiao Shi et al.
Ying Liu et al.
Treatment for Parkinson's disease (PD) has been impeded by inefficient treatment results and multiple membrane barriers during drug delivery. This study reports the design, synthesis, and application of microneedles (MNs) loaded with mitoch...
Lactobacillus rhamnosus GG-derived extracellular vesicles promote wound healing via miR-21-5p-mediated re-epithelization and angiogenesis [0.03%]
鼠李糖乳杆菌GG来源的细胞外囊泡通过miR-21-5p介导的复层上皮化和血管生成促进伤口愈合
Juan Wang,Xiaojie Li,Xinyue Zhao et al.
Juan Wang et al.
Extracellular vesicles (EVs), especially those derived from stem cells, have emerged as a novel treatment for promoting wound healing in regenerative medicine. However, the clinical application of mammalian cells-derived EVs is hindered by ...
A novel anti-CTLA-4 nanobody-IL12 fusion protein in combination with a dendritic cell/tumour fusion cell vaccine enhances the antitumour activity of CD8+ T cells in solid tumours [0.03%]
一种新型抗CTLA-4纳米抗体-IL12融合蛋白联合树突状细胞/肿瘤融合细胞疫苗增强实体瘤中CD8⁺T细胞的抗肿瘤活性
Meng-Jie Jiang,Hao-Peng Cui,Ting-Ting Li et al.
Meng-Jie Jiang et al.
Background: We previously developed a nanobody targeting CTLA-4 and demonstrated that it can boost antitumour T-cell responses in vitro; however, the resulting responses after the injection of T cells into cancer models a...
Antibody-targeted T cells and natural killer cells for cancer immunotherapy [0.03%]
抗体靶向T细胞和自然杀伤细胞的癌症免疫治疗
Ashley R Sutherland,Brijesh Parlekar,David W Livingstone et al.
Ashley R Sutherland et al.
Background: Adoptive cell cancer therapies aim to re-engineer a patient's immune cells to mount an anti-cancer response. Chimeric antigen receptor T and natural killer cells have been engineered and proved successful in t...
From ROS scavenging to boosted osseointegration: cerium-containing mesoporous bioactive glass nanoparticles functionalized implants in diabetes [0.03%]
从ROS清除到促进骨结合：包封铈的介孔生物活性玻璃纳米粒子功能化植介入物在糖尿病中的应用
Xue Jiang,Jianxu Wei,Xinxin Ding et al.
Xue Jiang et al.
Excessive production of reactive oxygen species (ROS) around titanium implants under diabetic conditions causes persistent inflammation, leading to poor osseointegration and even implant failure. Surface modification is an effective way to ...
A novel biomimetic nanovesicle containing caffeic acid-coupled carbon quantum dots for the the treatment of Alzheimer's disease via nasal administration [0.03%]
一种鼻内给药治疗阿尔茨海默病的含咖啡酸偶联碳量子点的仿生纳米囊泡
Yu Hu,Jingwen Cui,Junpeng Sun et al.
Yu Hu et al.
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive cognitive and physical impairment. Neuroinflammation is related to AD, and the misfolding and aggregation of amyloid protein in the brain creates an...