Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration [0.03%]
靶向骨关节炎中的FAP阳性软骨细胞：一种新的脂质纳米颗粒siRNA方法，以减轻软骨退变
Xiang Zhao,Jieming Lin,Mingyang Liu et al.
Xiang Zhao et al.
Background: Osteoarthritis (OA) is a common joint disease that leads to chronic pain and functional limitations. Recent research has revealed soluble fibroblast activation protein (FAP) secreted from OA synovium could deg...
Islet cell spheroids produced by a thermally sensitive scaffold: a new diabetes treatment [0.03%]
由热敏支架产生的胰岛细胞聚合体：一种新的糖尿病治疗方法
Xueting Yao,Zehua Gong,Wenyan Yin et al.
Xueting Yao et al.
The primary issues in treating type 1 diabetes mellitus (T1DM) through the transplantation of healthy islets or islet β-cells are graft rejection and a lack of available donors. Currently, the majority of approaches use cell encapsulation ...
AuCePt porous hollow cascade nanozymes targeted delivery of disulfiram for alleviating hepatic insulin resistance [0.03%]
负载戒酒硫的AuCePt多级中空纳米酶协同改善肝脏胰岛素抵抗作用研究
Huawei Shen,Yafei Fu,Feifei Liu et al.
Huawei Shen et al.
As the pathophysiological basis of type 2 diabetes mellitus (T2DM), insulin resistance (IR) is closely related to oxidative stress (OS) and inflammation, while nanozymes have a good therapeutic effect on inflammation and OS by scavenging re...
Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5 [0.03%]
巨噬细胞凋亡小体通过递送miR-143-3p靶向Igfbp5促进牙周炎骨吸收
Junhong Xiao,Yifei Deng,Jirong Xie et al.
Junhong Xiao et al.
Abstrct: BACKGROUND: Apoptotic vesicles (ApoVs), which are extracellular vesicles released by apoptotic cells, have been reported to exhibit substantial therapeutic potential for inflammatory diseases and tissue regenerat...
Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years [0.03%]
纳米抗体的发现：过去五年里应用和潜力的全面回顾
Elena Alexander,Kam W Leong
Elena Alexander
Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies found in the Camelidae family as well as cartilaginous fish. Their unique structural and functional properties, such as their small size, the ability to be...
m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia [0.03%]
circHIF1α通过与IGF2BP3蛋白KH结构域结合介导DNA损伤及G1/S期阻滞抵抗菌血症细菌感染的新机制研究
Jiang Yu,Yidan Gao,Fei Liu et al.
Jiang Yu et al.
Background: Animal and human health are seriously threatened by bacterial infections, which can lead to bacteremia and extremely high rates of morbidity and mortality. Recently, there have been reports indicating the invo...
Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration [0.03%]
用于气管粘膜再生的具有组织粘附、抗菌和促血管生成性能的铜氢磷酸盐纳米片功能化水凝胶
Pengli Wang,Erji Gao,Tao Wang et al.
Pengli Wang et al.
Timely and effective interventions after tracheal mucosal injury are lack in clinical practices, which elevate the risks of airway infection, tracheal cartilage deterioration, and even asphyxiated death. Herein, we proposed a biomaterial-ba...
Curcumin/pEGCG-encapsulated nanoparticles enhance spinal cord injury recovery by regulating CD74 to alleviate oxidative stress and inflammation [0.03%]
姜黄素/pEGCG纳米粒通过调节CD74来缓解氧化应激和炎症从而促进脊髓损伤修复
Tianjun Chen,Li Wan,Yongchun Xiao et al.
Tianjun Chen et al.
Spinal cord injury (SCI) often accompanies impairment of motor function, yet there is currently no highly effective treatment method specifically for this condition. Oxidative stress and inflammation are pivotal factors contributing to seve...
Photoimmunotherapy using indocyanine green-loaded Codium fragile polysaccharide and chitosan nanoparticles suppresses tumor growth and metastasis [0.03%]
利用海带硫酸多糖和壳聚糖纳米颗粒的光免疫疗法抑制肿瘤生长和转移
Dayoung Ryu,Hae-Bin Park,Eun-Koung An et al.
Dayoung Ryu et al.
Metastasis and recurrence are the main challenges in cancer treatment. Among various therapeutic approaches, immunotherapy holds promise for preventing metastasis and recurrence. In this study, we evaluated the efficacy of treating primary ...
Maternal exposure to nanopolystyrene induces neurotoxicity in offspring through P53-mediated ferritinophagy and ferroptosis in the rat hippocampus [0.03%]
母体暴露于纳米聚苯乙烯通过P53介导的铁蛋白自噬和铁死亡诱导后代海马神经毒性
Jiang Chen,Licheng Yan,Yaping Zhang et al.
Jiang Chen et al.
There are increasing concerns regarding the rapid expansion of polystyrene nanoplastics (PS-NPs), which could impact human health. Previous studies have shown that nanoplastics can be transferred from mothers to offspring through the placen...