Dual targeting and bioresponsive nano-PROTAC induced precise and effective lung cancer therapy [0.03%]
双靶向和生物响应型纳米 PROTAC 用于精确有效的肺癌治疗
Xiaoling Guan,Xiaowei Xu,Yiwen Tao et al.
Xiaoling Guan et al.
Epigenetic regulation has emerged as a promising therapeutic strategy for lung cancer treatment, which can facilitate the antitumor responses by modulating epigenetic dysregulation of target proteins in lung cancer. The proteolysis-targetin...
Exploring the cytotoxic and antioxidant properties of lanthanide-doped ZnO nanoparticles: a study with machine learning interpretation [0.03%]
镧离子掺杂的ZnO纳米粒子的细胞毒性和抗氧化特性的研究及机器学习解析
Jorge L Mejia-Mendez,Edwin E Reza-Zaldívar,A Sanchez-Martinez et al.
Jorge L Mejia-Mendez et al.
Background: Lanthanide-based nanomaterials offer a promising alternative for cancer therapy because of their selectivity and effectiveness, which can be modified and predicted by leveraging the improved accuracy and enhan...
Ion osmolarity-driven sequential concentration-enrichment for the scale-up isolation of extracellular vesicles [0.03%]
离子渗透压驱动的顺序浓缩-富集用于细胞外囊泡的大规模分离
Lizhi Wang,Junhao Xia,Xin Guan et al.
Lizhi Wang et al.
Extracellular vesicles (EVs) carry a variety of bioactive molecules and are becoming a promising alternative to cell therapy. Scale-up EV isolation is necessary for their functional studies and biological applications, while the traditional...
Correction: Exosomal miR-1a-3p derived from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of BMSCs in glucocorticoid-associated osteonecrosis of the femoral head by targeting Cebpz [0.03%]
纠正：糖皮质激素刺激的M1型巨噬细胞来源的外泌体miR-1a-3p通过靶向Cebpz促进糖皮质激素相关股骨头坏死中BMSCs的成脂分化
Ping Duan,Yong-Le Yu,Yan-Nan Cheng et al.
Ping Duan et al.
Published Erratum
Journal of nanobiotechnology. 2024 Nov 11;22(1):694. DOI:10.1186/s12951-024-02958-8 2024
Manipulation in root-associated microbiome via carbon nanosol for plant growth improvements [0.03%]
基于碳纳米溶胶的植物根系相关微生物组操控及其促生作用机制研究
Lingtong Cheng,Jiemeng Tao,Peng Lu et al.
Lingtong Cheng et al.
Background: Modulating the microbiome with nanomaterials has been proposed to improve plant growth, and reduce reliance on external inputs. Carbon Nanosol (CNS) was attracted for its potential to improve plant productivit...
Binding-driven forward tearing protospacer activated CRISPR-Cas12a system and applications for microRNA detection [0.03%]
基于强结合正向撕裂PAM的CRISPR-Cas12a系统及其在microRNA检测中的应用
Lina Zhao,Xiangyu Deng,Yuqing Li et al.
Lina Zhao et al.
CRISPR-Cas12a system, characterized by its precise sequence recognition and cleavage activity, has emerged as a powerful and programmable tool for molecular diagnostics. However, current CRISPR-Cas12a-based nucleic acid detection methods, p...
Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment [0.03%]
仿生多巴胺纳米复合支架移植通过调节抑制性微环境促进视神经再生
Tonghe Pan,Yate Huang,Jinfei Wei et al.
Tonghe Pan et al.
Optic nerve regeneration remains challenging worldwide due to the limited intrinsic regenerative capacity of retinal ganglion cells (RGCs) and the inhibitory microenvironment. Oxidative stress, induced by excessive reactive oxygen species (...
Organoids and organoid extracellular vesicles-based disease treatment strategies [0.03%]
基于类器官和类器官外泌体的疾病治疗策略
Guangyin Zhou,Ruiyang Li,Shihao Sheng et al.
Guangyin Zhou et al.
Organoids are "mini-organs" that self-organize and differentiate from stem cells under in vitro 3D culture conditions, mimicking the spatial structure and function of tissues in vivo. Extracellular vesicles (EVs) are nanoscale phospholipid ...
Cascade-catalysed nanocarrier degradation for regulating metabolism homeostasis and enhancing drug penetration on breast cancer [0.03%]
级联催化型纳米药物递送系统用于调节代谢稳态并增强乳腺癌治疗药物渗透性
Fang Zhang,Kai Cheng,Xiao-Shuai Zhang et al.
Fang Zhang et al.
The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy. Herein, an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed, which can dilate vessle and im...
A temperature-ultrasound sensitive nanoparticle delivery system for exploring central neuroinflammation mechanism in stroke-heart syndrome [0.03%]
一种温度-超声敏感的纳米颗粒递送系统用于探究中风心脏综合征中枢神经炎症机制
Mingzhou Jiang,Zhidong Zhu,Ziyu Zhou et al.
Mingzhou Jiang et al.
Background: Cardiovascular events secondary to stroke-collectively classified as stroke-heart syndrome-greatly impair the patient's prognosis, however its underlying mechanism has yet to be determined. To investigate the ...