A stable two-component cationic liposome platform for mRNA delivery induces CD8+ T-cell responses and protection in a murine lymphoma model [0.03%]
一种稳定的两组分阳离子脂质体平台能够递送mRNA并可在小鼠淋巴瘤模型中诱发CD8+t细胞响应和保护作用
Gabriel Kristian Pedersen,Reham Sabah Alhakeem,Ahmad Tami et al.
Gabriel Kristian Pedersen et al.
The mRNA-LNP-based SARS-CoV-2 vaccines were a breakthrough for the technology; however, their production requires specialized equipment, and the complex formulation involving four distinct lipid classes imposes stringent requirements on bot...
Natural panax notoginseng-derived nanovesicles trigger multiple cell death mechanisms and reprogram chemokine signaling to impede oral squamous cell carcinoma progression [0.03%]
天然南美人参衍生的纳米囊泡触发多种细胞死亡机制并重新编程趋化因子信号以阻碍口腔鳞状细胞癌的发展
Xiaohang Chen,Meifang Lin,Xuzheng Zhan et al.
Xiaohang Chen et al.
Oral squamous cell carcinoma (OSCC) remains one of the most aggressive malignancies of the oral epithelium, with limited therapeutic options effectively targeting both tumor growth and metastasis. Plant-derived nanovesicles have emerged as ...
Selenium nanoparticles with bioorthogonal targeting to boost CAR-cell therapy for colorectal cancer [0.03%]
用于结直肠癌CAR细胞治疗的生物正交靶向硒化银纳米颗粒
Jinfan Zhou,Gaohua Li,Yunze Xu et al.
Jinfan Zhou et al.
The treatment of solid tumors with chimeric antigen receptor natural killer (CAR-NK) cell therapy confronts significant barriers, notably poor cellular infiltration and a highly immunosuppressive tumor microenvironment (TME). To overcome th...
Leukemia-targeting NK cell nanoengagers effectively promote robust NK activation and potent anti-acute myeloid leukemia response [0.03%]
靶向白血病的NK细胞纳米活化剂可有效促进强力NK激活和强烈抗急性髓系白血病反应
Hyo Jeong Kim,Heejin Jun,Hyun Bin Lee et al.
Hyo Jeong Kim et al.
Natural killer (NK) cells are key components of innate immunity, playing a pivotal role in tumor recognition and eradication, and numerous NK cell-based immunotherapeutic approaches have been extensively investigated for cancer treatment. H...
Bioinformatic and computational biophysics tools for nanopore engineering: a review from standard approaches to machine learning advancements [0.03%]
纳米孔工程的生物信息和计算生物物理工具综述：从标准方法到机器学习的发展
Marco Reccia,Francesco Quilli,Kherim Willems et al.
Marco Reccia et al.
Nanopores are key components in several emerging technologies. Nanopore sensors allow the observation of single molecules from the signature they leave in the ionic current flowing through the pore, while nanoporous membranes provide a pote...
Matrix micro/nano-topography drives oncogenic signaling and drug response in a 3D osteosarcoma model [0.03%]
基质微/纳米拓扑在三维骨肉瘤模型中的致癌信号传导和药物反应中的作用
Mei-Ling Wang,Xu Cai,Feng Lv et al.
Mei-Ling Wang et al.
Osteosarcoma (OS) research is constrained by a scarcity of clinical samples and traditional models that inadequately replicate the natural micro/nano-structure of bone. The role of these topological features in sustaining cellular function ...
pH-responsive selenium nanoplatform for targeted drug release and immune remodeling in microbiota-associated colorectal cancer [0.03%]
基于肠道微生物的酸响应硒纳米药物平台用于结直肠癌精准治疗及免疫重塑
Haodi Ma,Liying Zhang,Lulu Wang et al.
Haodi Ma et al.
Fusobacterium nucleatum (F. nucleatum) is implicated in colorectal cancer (CRC) initiation, progression, and resistance to therapy, while conventional antibiotics show poor specificity and disrupt intestinal homeostasis. Here, we present a ...
Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-responsive brown adipose tissue for targeted neuroinflammation modulation [0.03%]
来源于响应脊髓损伤的棕色脂肪组织的工程化外泌体递送Angiopep-2以靶向调节神经炎症
Shijun Xiang,Tian Qin,Yiming Qin et al.
Shijun Xiang et al.
Spinal cord injury (SCI) affects over 15 million people globally with no curative treatments available. While primary mechanical trauma initiates tissue damage, secondary pathological cascades including neuroinflammation and mitochondrial d...
Spatial and cellular composition of lung fibrosis induced by multi-walled carbon nanotubes [0.03%]
多壁碳纳米管诱导的肺纤维化的空间和细胞组成
Biqi Han,Xinwei Li,Jiayi Li et al.
Biqi Han et al.
Background: The pulmonary immune system orchestrates lung homeostasis and protects against environmental insults through coordinated actions of immune and structural cells. Traditional Chinese medicine recognized the func...
Correction: Multifunctional carbomer based ferulic acid hydrogel promotes wound healing in radiation-induced skin injury by inactivating NLRP3 inflammasome [0.03%]
纠正：基于卡波姆的富马酸水凝胶通过抑制NLRP3炎性小体促进放射性皮肤损伤愈合多功能 carbomer 基富马酸水凝胶促进放射性皮肤病伤口愈合中激活 NLRP3 inflammasome
Congshu Huang,Chaoji Huangfu,Zhijie Bai et al.
Congshu Huang et al.
Published Erratum
Journal of nanobiotechnology. 2026 Mar 4;24(1):209. DOI:10.1186/s12951-025-03971-1 2026