In situ imaging of proximal biomolecules via Proximity Anchored Modules Assembly [0.03%]
基于近距离锚定模块的近端生物分子原位成像技术
Yuting Zou,Zhangling Liu,Yunpeng Shu et al.
Yuting Zou et al.
Aberrant proximal biomolecular complexes are critical disease biomarkers. The precise in situ imaging of these complexes is essential for deciphering disease pathogenesis and precision diagnostics. However, current in situ analysis technolo...
Single-cell transcriptomics-guided dynamic hydrogel delivery of artemisia argyi-derived EVs relieves ER stress and promotes diabetic wound regeneration [0.03%]
单细胞转录组学指导的动态姜黄制剂递送系统促进糖尿病伤口再生
Dazhuang Miao,Xiaopeng Suo,Xinqian Geng et al.
Dazhuang Miao et al.
Diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and delayed tissue regeneration, yet effective strategies to regulate the pathological immune microenvironment remain limited. Here, integrated single-cell...
Self-assembling pH-responsive peptide nanoparticles delivering pyrvinium pamoate induce osteosarcoma senescence through CBX4 ubiquitination-mediated inhibition of YAP1 SUMOylation [0.03%]
一种自组装的pH响应肽纳米颗粒通过CBX4泛素化介导的YAP1SUMOylation抑制递送pireviniumpamoate诱导成骨肉瘤细胞衰老
Renyi Zhou,Yue Ma,Xudong Liu et al.
Renyi Zhou et al.
Osteosarcoma is a highly malignant and metastasis-prone bone tumor, and current treatment options remain unsatisfactory, underscoring the urgent need for new targeted strategies. Induction of cellular senescence represents a promising non-a...
Enzyme-enhanced albumin-stabilized nanopolymers for cascade catalysis-driven ferroptosis-immunotherapy [0.03%]
基于酶促级联催化的纳米聚合物用于铁死亡免疫治疗
Peng Yu,Shuchun Yu,Xiaoping Yin et al.
Peng Yu et al.
Ferroptosis, an iron-dependent form of programmed cell death, holds significant promise for cancer therapy due to its unique redox-driven mechanism and immunogenic potential. However, its therapeutic efficacy is often compromised by inadequ...
A bioadhesive antioxidant dual-crosslinked hydrogel mitigates endothelial pyroptosis to enhance ischemic flap survival [0.03%]
一种生物粘附抗氧化双重交联的水凝胶通过减轻内皮细胞焦亡来增强缺血瓣膜的存活率
Kai Yang,Pei Zou,Yikun Ju et al.
Kai Yang et al.
Multiterritory perforator flaps are widely used in reconstructive surgery; however, distal regions, particularly the choke zone, remain highly susceptible to necrosis due to sustained ischemia, oxidative stress, and endothelial inflammatory...
Targeting tumor-associated bacteria in digestive system cancers: carcinogenic mechanisms and nano-regulate platform design [0.03%]
消化系统肿瘤相关细菌的靶向研究：致癌机制和纳米调控平台设计
Hongyu Liu,Xin Wang,Q I Xi et al.
Hongyu Liu et al.
Tumor-associated bacteria (TAB) and their products can reprogram host signaling and metabolism, disrupt tissue homeostasis, and remodel antitumor immunity, collectively creating a cooperative protumor ecosystem. Accumulating evidence indica...
Cardiac-targeted delivery of miRNA via antioxidant nanozymes ameliorates cardiac dysfunction and fibrosis after myocardial infarction [0.03%]
抗氧化纳米酶介导的心肌梗死后心脏靶向递送microRNA以改善心功能及纤维化水平
Tong Yu,Jingyi Gong,Ping Pang et al.
Tong Yu et al.
Despite advances in reperfusion therapy, treatment outcomes for myocardial infarction (MI) remain limited by poor targeting specificity and insufficient bioavailability of therapeutic agents in the ischemic myocardium. Here, we report CCTP-...
A novel Au-Se nanoplatform for co-delivery of cGAMP and acriflavine synergizes with photothermal therapy to enhance anti-tumor immunity via STING activation and HIF-1α inhibition [0.03%]
一种新型的Au-Se纳米平台通过STING激活和HIF-1α抑制协同光热疗联合递送cGAMP和吖啶橙以增强抗肿瘤免疫能力
Yuanyuan Cui,Yonghui Liang,Huixin Yang et al.
Yuanyuan Cui et al.
Activating the stimulator of interferon genes (STING) pathway is a potent strategy for promoting tumor vascular normalization and enhancing cancer immunotherapy. However, the poor metabolic stability of classical STING agonists limits their...
A dual-mechanism injectable hydrogel integrating reactive oxygen species regulationand low-level laser therapy for androgenetic alopecia remediation [0.03%]
一种用于雄激素性脱发治疗的集调节活性氧和低强度激光疗法于一体的双机制注射水凝胶
Jingwen Wang,Kang Fu,Yue Yu et al.
Jingwen Wang et al.
Androgenetic Alopecia (AGA) is a chronic disease characterized by follicular degenerative changes and the continuous deterioration of the follicular microenvironment. Excessive accumulation of reactive oxygen species (ROS) and insufficient ...
Degradable MMP9-responsive high-density lipoprotein nanoparticles enable efficient siRNA-PGRN and quercetin delivery to remodel the fibrotic microenvironment and attenuate renal fibrosis [0.03%]
一种可降解的MMP9响应型高密度脂蛋白纳米颗粒通过高效递送siRNA-PGRN和芦丁来重塑纤维化微环境并减轻肾纤维化
Weichao Tu,Hao Yan,Yikun He et al.
Weichao Tu et al.
Renal fibrosis is the final common pathway of chronic kidney disease and remains a challenge due to the complex fibrotic and inflammatory microenvironment. This study aimed to develop an enzyme-responsive, fibrosis-targeted nanotherapeutic ...