Gambogic acid-iron nanozymes as effective carriers for enhanced chemotherapy by inducing excessive autophagy and oxidative stress [0.03%]
gambogic酸-铁纳米酶通过诱导过度自噬和氧化应激增强化疗的作用机制研究
Yang Qiao,Menghui Liu,Yiqun Zhang et al.
Yang Qiao et al.
The complex dual role of autophagy provides new insights for enhancing tumor treatment efficacy. However, effectively regulating this process is key to enhancing therapeutic efficacy. To address this challenge, this study designed a gambogi...
Atractylodes macrocephala-derived extracellular vesicles-like particles enhance the recovery of ulcerative colitis by remodeling intestinal microecological balance [0.03%]
苍术大根提取的外泌体样颗粒通过重塑肠道微生态平衡促进溃疡性结肠炎修复
Xuejun Tan,Bowen Gao,Yukun Xu et al.
Xuejun Tan et al.
Current treatment of ulcerative colitis (UC) remains challenging, with the mainstay of therapy being 5-aminosalicylic acid-based drugs, which have limited and inconsistent results. Atractylodes macrocephala (AM) is a traditional Chinese med...
Sonodynamic therapy-boosted biomimetic nanoplatform targets ferroptosis and CD47 as vulnerabilities for cancer immunotherapy [0.03%]
声动力学增强的仿生纳米平台靶向铁死亡和CD47作为癌症免疫治疗的弱点
Haiqin Liao,Mingyu Chen,Zhipeng Liao et al.
Haiqin Liao et al.
The efficacy of cancer immunotherapy is frequently hindered by the immunosuppressive "cold" tumor microenvironment. Inducing immunogenic cell death (ICD) may address this limitation. Ferroptosis, a form of ICD characterized by iron-dependen...
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma [0.03%]
集抗肿瘤/抗炎和促组织修复为一体的鼻咽癌治疗新策略
Fan Ni,Hanxin Lv,Liting Lin et al.
Fan Ni et al.
Nasopharyngeal carcinoma (NPC) is one of the most prevalent cancers in the head and neck region. The development of innovative therapies that are effective at eliminating tumors while minimizing damage to surrounding normal tissues due to p...
Size-tuned PEGylated NIR-II fluorescent probes for high-contrast plant imaging and TMV detection [0.03%]
尺寸可调的PEG修饰的NIR-II荧光探针用于高对比度植物成像和TMV检测
Fang Zhao,Yu-Ling Xu,Meng-Jiao Lu et al.
Fang Zhao et al.
The widespread applications of fluorescence imaging in plant science still suffer from challenges including strong auto-fluorescence (chlorophyll) and tissue light scattering, resulting in low signal-to-background ratio (SBR) for in vivo bi...
Tumor microenvironment remodeling with a telomere-targeting agent and its cooperative antitumor effects with a nanovaccine [0.03%]
端粒靶向剂引起的肿瘤微环境重塑及其与纳米疫苗协同抗肿瘤作用
Jing Bai,Mengzhen Wang,Yiming Luo et al.
Jing Bai et al.
The nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG, also known as THIO) is a telomere-targeting agent with important clinical potency. It can selectively kill telomerase-positive tumor cells. We previously reported that THIO could ...
Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation [0.03%]
膳食大麦叶来源的植物乳杆菌衍生的外泌体通过抑制Citrobacter rodentium感染和肠道炎症而产生抗炎作用
Yu Feng,Qian Zhao,Yifan Zhao et al.
Yu Feng et al.
Background: Inflammatory bowel disease (IBD) is a gastrointestinal inflammatory disorder characterized by disturbed interactions between gut microbiota and host immune response. Barley leaf (BL) is a traditional Chinese h...
Dynamic QSAR modeling for predicting in vivo genotoxicity and inflammation induced by nanoparticles and advanced materials: a time-dose-property/response approach [0.03%]
基于时间-剂量的定量构效关系模型用于预测纳米材料和新兴材料诱导的体内遗传毒性及炎症效应
Michalina Miszczak,Kabiruddin Khan,Pernille Høgh Danielsen et al.
Michalina Miszczak et al.
Predicting the health risks of nanoparticles (NPs) and advanced materials (AdMa) is a critical challenge. Due to the complexity and time-consuming nature of experimental testing, there is a reliance on in silico methods such as quantitative...
Targeting Dicer reprograms tumor-associated macrophages to promote anti-tumoral immunity in colorectal cancer liver metastasis [0.03%]
靶向Dicer可使肿瘤相关巨噬细胞重编程以促进结直肠癌肝转移的抗肿瘤免疫反应
Shenglong Xia,Wenwen Chen,Zhengyang Xu et al.
Shenglong Xia et al.
Background: Tumor-associated macrophages (TAMs) contribute significantly to immunosuppression in colorectal cancer liver metastasis (CRLM), leading to high aggressiveness and poor prognosis. However, the key molecules inv...
Zinc-doped curcumin carbon dots promote infected wound healing with photodynamic via the VEGF signaling pathway [0.03%]
锌掺杂姜黄素碳点通过VEGF信号通路促进感染伤口的光动力愈合
Yifan Zhao,Jia Liu,Lingxiang Sun et al.
Yifan Zhao et al.
Management of bacterial infected wounds remains challenging due to the open, susceptibility to infection and delayed healing characteristics of damaged wounds, and there is an urgent need for non-antibiotic-based wound healing strategies. H...