Self-activated prodrug nanocomposites reprogramming lactic acid metabolism to initiate acidosis-endoplasmic reticulum stress cascade and potentiate immunogenic cell death for enhanced liver cancer therapy [0.03%]
自激活前药纳米复合物重新编程乳酸代谢以启动酸中毒-内质网应激级联并增强免疫原性细胞死亡以改善肝癌治疗
JingQuan Chen,WeiYi Cheng,WeiYe Ren et al.
JingQuan Chen et al.
Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited therapeutic efficacy and poor prognosis. To address chemoresistance and immunosuppression in HCC, we developed a lactate-modulating multifunctional prodrug...
Self-reinforcing nanomedicine orchestrates EPR effect and neutrophil hitchhiking for spatiotemporal accumulation in solid tumors [0.03%]
一种自增强型纳米药物可在实体肿瘤中调控EPR效应和中性粒细胞载运作用实现时空特异性富集
Yiqiong Liu,Dailin Xu,Jianwei Cheng et al.
Yiqiong Liu et al.
Targeted drug delivery remains pivotal for enhancing therapeutic efficacy in cancer treatment. While nanomedicines harness the enhanced permeability and retention (EPR) effect for passive tumor accumulation, their efficacy is often hindered...
IL-15 signaling via cis- and trans-presentation to progenitor-exhausted CD8+ T cells enhances radio-immunotherapy efficacy in ESCC [0.03%]
通过原位和反式呈递IL-15信号可增强祖细胞耗竭的CD8+t细胞在食管鳞癌放射免疫治疗中的疗效
Yi You,Linrui Gao,Shijia Li et al.
Yi You et al.
Background: Concurrent chemoradiotherapy (CRT) combined with PD-1/PD-L1 targeting immunotherapy (IM) has emerged as a promising treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, individual...
Active-targeting biomimetic nanosystem for prostate cancer enhances radiotherapy efficacy by inducing ferroptosis [0.03%]
主动靶向仿生纳米系统通过诱导铁死亡增强前列腺癌放射治疗疗效
Zhihao Hu,Hongji Li,Kai Gan et al.
Zhihao Hu et al.
Radioresistance and off-target toxicity remain major challenges in prostate cancer (PCa) radiotherapy. Here, we report a biomimetic nanoplatform (Au/MOF-FIN@M-gy1) that synergistically enhances radiation deposition and ferroptosis for preci...
The potential of nanotechnology for photothermal therapy-based synergistic immunotherapy: a review [0.03%]
纳米技术在基于光热疗法的协同免疫治疗中的潜力：综述
Xiao-Kai Chi,Xiao Zhang,Jin Su et al.
Xiao-Kai Chi et al.
With the continuous discovery of new materials and a deeper understanding of tumor diseases, more possibilities have been identified for the delivery of antitumor drugs and the treatment of tumors. Currently, the treatment of tumors is not ...
A metabolic reprogramming and trained immunity hydrogel mimic cluster missiles to eliminate infection and treat infected diabetic wounds [0.03%]
代谢重编和训练免疫水凝胶模拟集群导弹消除感染并治疗糖尿病感染伤口
Zirui Yu,Zhenyi Chen,Hongxia Xie et al.
Zirui Yu et al.
Excessive inflammation, infection, persistent reactive oxygen species (ROS) accumulation, hyperglycemia, and vascular lesions in diabetic chronic wounds severely impair healing. Currently, there is no treatment regimen available to improve ...
Improving T cell expansion by optogenetically engineered bacteria-loaded MMP-2-responsive cyclophosphamide for antitumor immunotherapy [0.03%]
一种用于抗肿瘤免疫治疗的光遗传工程菌载MMP-2响应型环磷酰胺改善T细胞扩增
Jiawen Chen,Renjiang Kong,Yuzhi Qiu et al.
Jiawen Chen et al.
The efficacy of antitumor immunotherapy is closely associated with the expansion of tumor-infiltrating CD8+ T cells. However, within the tumor microenvironment, CD8+ T cells often exhibit reduced proliferation due to persistent exposure to ...
Mitochondrial-targeted photodynamic therapy combined with TGF-β inhibition potentiates anti-PD-1 therapy in pancreatic ductal adenocarcinoma [0.03%]
线粒体靶向光动力疗法联合TGF-β抑制增敏胰腺导管腺癌免疫治疗
Shijin Xu,Naidi Yang,Fangning Du et al.
Shijin Xu et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, marked by extensive stromal fibrosis and a profoundly immunosuppressive, immune-excluded tumor microenvironment (TME) that hampers the efficacy of immune c...
Photocurable hydrogel containing MOF nanoenzymes for comprehensive pulpitis treatment: antibacterial, anti-inflammatory, and osteogenic actions [0.03%]
一种含MOF纳米酶的光固化水凝胶全面治疗牙髓炎：抗菌、抗炎和促成骨作用
Fei Xie,Chuanda Zhu,Man Qin et al.
Fei Xie et al.
Maintaining the vitality of the dental pulp tissue is the core therapeutic objective in treating reversible pulpitis, with the key being the achievement of a biological balance in the pulp microenvironment. However, the materials currently ...
Yaru Quan,Huijie Yang,Wei Li et al.
Yaru Quan et al.
mRNA vaccine technology platform has evolved rapidly in recent years, which has emerged as an important direction in vaccine development. Establishing a quality control platform based on its Critical Quality Attributes (CQAs) is fundamental...