Dual-engineered Treg-Exosome-IKVAV nanovesicles spatiotemporally sequentially regulate neuro-immune microenvironment to promote spinal cord injury repair [0.03%]
双工程Treg-外泌体-IKVAV纳米囊泡时空序贯调节神经免疫微环境促进脊髓损伤修复
Su Xinjin,Gu Changjiang,Zeng Feihui et al.
Su Xinjin et al.
Spinal cord injury (SCI) repair remains a significant clinical challenge due to the imbalance of inflammatory microenvironment and insufficient neural regenerative ability. Current therapeutic approaches, such as pharmaceuticals, stem cell ...
Lung-targeted RNA delivery systems: strategies and therapeutic applications [0.03%]
肺部靶向RNA传递系统：策略与治疗应用
Shenrui Xu,Min Li,Tingting Wang et al.
Shenrui Xu et al.
Pulmonary diseases, encompassing asthma, lung cancer, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis, constitute major contributors to global morbidity and mortality, imposing substantial burdens on healthcare systems ...
Pathology-tailored nanotherapy via Galectin-3-targeted and triple-responsive nanoparticles enables multimodal therapy against aortic dissection [0.03%]
通过Galectin-3靶向和三重刺激响应型纳米颗粒实现针对主动脉夹层的多模式治疗病理学指导的纳米疗法
Chi Lin,Min-Lang Tsai,Hsin-Yi Chao et al.
Chi Lin et al.
Aortic dissection (AD) is a life‑threatening vascular disorder with high mortality and no effective pharmacological treatment. Addressing its multicellular and dynamic pathology requires strategies that precisely modulate inflammatory and ...
pH-responsive and dual-dynamically crosslinked metal-phenolic hydrogel for synergistic macrophage and Th17/Treg reprogramming in diabetic wounds [0.03%]
用于糖尿病伤口的PH响应型和双动态交联金属酚类水凝胶，可协同巨噬细胞和Th17/Treg重编程
Yuheng Liao,Yanzhi Zhao,Chenyan Yu et al.
Yuheng Liao et al.
In recent years, there has been a progressive increase in the cumulative number of individuals afflicted with diabetic wounds, elevating this condition to a global public health concern of significant magnitude. The disruption of the immune...
Degradable scaffold-mediated synergistic matrix formation by endogenous cells: an in vivo manufacturing strategy for off-the-shelf vascular grafts to address clinical shortages [0.03%]
可降解支架介导的内源性细胞协同基质形成：现货血管移植物的体内制造策略，以解决临床短缺问题
Yijie He,Yunfei Mo,Xiaoyan Shen et al.
Yijie He et al.
Tumor-homing cerium nanozyme platform enables coordinated drug release and STING activation for bladder cancer treatment [0.03%]
肿瘤靶向铈纳米酶平台用于协同药物释放和STING活化以治疗膀胱癌
Zhiming Wu,Jiamin Zeng,Longbao Feng et al.
Zhiming Wu et al.
Non-muscle-invasive bladder cancer (NMIBC) carries 70% incidence yet remains plagued by high recurrence because single-modality chemotherapy or immunotherapy is crippled by rapid urinary clearance, poor tumor specificity, and narrow therape...
Gated MoS2/SiN nanochannel for tunable ion transport and protein translocation [0.03%]
具有可调离子传输和蛋白质转运功能的MoS2 / SiN纳米通道的大门
Shukun Weng,Ali Douaki,Makusu Tsutsui et al.
Shukun Weng et al.
Porphyromonas gingivalis-derived outer membrane vesicles promote vascular endothelial glycocalyx injury via the PPAD/CitH3/B3GAT1 pathway [0.03%]
牙龈卟啉单胞菌来源的外泌体通过PPAD/CitH3/B3GAT1途径促进血管内皮细胞糖萼损伤
Shoucheng Yin,Qihui Qiao,Zhaorong Li et al.
Shoucheng Yin et al.
Background: The glycocalyx serves as the skeletal structure of the outer layer of endothelial cells and regulates the function of endothelial cells. Porphyromonas gingivalis (P. gingivalis) outer membrane vesicles (OMVs) ...
In situ encapsulation of Cu-MOF in wax gourd sponge for integrated smart treatment of diabetic wounds [0.03%]
冬瓜海绵中Cu-MOF的原位封装技术在糖尿病伤口智能治疗中的应用研究
Qiliang Zhai,Xiaoling Deng,Yubo Gao et al.
Qiliang Zhai et al.
Unraveling the structure-activity relationship of alloying in nanozyme design for synergistic tumor metabolic-immunotherapy [0.03%]
解密纳米酶设计中合金结构活性关系的协同肿瘤代谢免疫疗法研究
Chaoran Liu,Wenyu Zhang,Qingbin He et al.
Chaoran Liu et al.
Catalyzing the glucose cascade reaction to impair tumor cell energy metabolism represents a promising strategy for tumor therapy. However, the application of natural enzymes as therapeutic agents remains limited by various challenges. Altho...