Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models [0.03%]
用于治疗小鼠心肌缺血再灌注损伤的铁螯合心肌细胞线粒体靶向纳米酶系统
Ke Zhu,Kun Wang,Rongting Zhang et al.
Ke Zhu et al.
Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI), posing a significant clinical challenge. Nanoenzymes like cerium oxide (CeO2) hold promise for mitigating oxidative damage and inhibiting ferroptosis, but t...
A shark-derived broadly neutralizing nanobody targeting a highly conserved epitope on the S2 domain of sarbecoviruses [0.03%]
靶向sarbecovirus S2区域的高度保守表位的广谱中和纳米体
Bo Feng,Cuiyun Li,Zhaoyong Zhang et al.
Bo Feng et al.
The continuously evolving Omicron subvariants has diminished the effectiveness of almost all RBD-targeted antibodies in neutralizing these subvariants. The development of broad-spectrum neutralizing antibodies is desired for addressing both...
Carrier-free nanoparticles-new strategy of improving druggability of natural products [0.03%]
无载体纳米颗粒-提高天然产物成药性的新策略
Yaqi Yao,Zhenna Xu,Haoran Ding et al.
Yaqi Yao et al.
There are abundant natural products resources and extensive clinical use experience in China. However, the active components of natural products generally have problems such as poor water solubility and low bioavailability, which limit thei...
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity [0.03%]
姜黄素-顺铂纳米药物协同促进骨肉瘤细胞铁死亡及化疗敏感性
Zili Lin,Yusheng Li,Ziyi Wu et al.
Zili Lin et al.
The ever-increasing chemoresistance of osteosarcoma (OS) has been observed in the recent decades, impeding OS therapeutic improvement and posing an urgency to exploit to the alternative and/or supplementary therapies for the optimization of...
Biomaterial-based vascularization strategies for enhanced treatment of peripheral arterial disease [0.03%]
基于生物材料的血管化策略增强外周动脉疾病的治疗效果
Haojie Wang,Fuxin Lin,Yibin Zhang et al.
Haojie Wang et al.
Peripheral arterial disease (PAD) poses a global health challenge, particularly in its advanced stages known as critical limb ischemia (CLI). Conventional treatments often fail to achieve satisfactory outcomes. Patients with CLI face high r...
Bacterial membrane-modified cerium oxide nanoboosters enhance systemic antitumor effects of radiotherapy in metastatic triple-negative breast cancer [0.03%]
细菌膜修饰的铈基纳米药物增强放射治疗转移性三阴乳腺癌的全身抗肿瘤效应
Shuo-Fu Chen,Pui-Lam Ng,Chen-Wei Lai et al.
Shuo-Fu Chen et al.
Background: Radiotherapy plays an important role in the treatment of triple-negative breast cancer, yet its ability to trigger systemic responses against distant tumors remains limited. ...
Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding [0.03%]
负载铜离子介孔生物活性玻璃的冷冻凝胶在急性和难治性出血中的增效止血效果
Qixiu Hou,Xu He,Mengting Guo et al.
Qixiu Hou et al.
Uncontrolled acute and persistent bleeding, as well as with infection, is a great challenge because of the high mortality during treating the patients with injuries, complex surgery or bone marrow failure. Here, we develop an external form ...
Integrating synthetic polypeptides with innovative material forming techniques for advanced biomedical applications [0.03%]
结合创新材料成型技术的合成多肽在先进生物医学应用中的集成研究
Dandan Kang,Yu Zhang,Deng-Guang Yu et al.
Dandan Kang et al.
Polypeptides are highly valued in biomedical science for their biocompatibility and biodegradability, making them valuable in drug delivery, tissue engineering, and antibacterial dressing. The diverse design of polymer chains and self-assem...
Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair [0.03%]
用于有效促进衰老骨修复的具有序贯细胞募集和成骨功能的工程外泌体
Lei Qi,Jing Wang,Jinge Yan et al.
Lei Qi et al.
Senescent mandibular bone repair poses a formidable challenge without a completely satisfactory strategy. Endogenous cell recruitment and osteogenic differentiation are two sequential stages in bone regeneration, and disruptions in these tw...
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin [0.03%]
携带氧气和胆囊收缩素的靶向超声分子探针在体早期评估和治疗心室重构
Can Wang,Hongfeng Cheng,Xiaoying Dong et al.
Can Wang et al.
Early identification and treatment of ventricular remodeling (VR) are crucial for delaying the progression of heart failure after myocardial infarction. This study aims to develop a dual-responsive phase-shift molecular probe loaded with a ...