De novo strategy of organic semiconducting polymer brushes for NIR-II light-triggered carbon monoxide release to boost deep-tissue cancer phototheranostics [0.03%]
用于近红外光触发一氧化碳释放的从头设计有机半导体聚合物刷子以增强深层组织癌症光诊疗
Caijun Zhu,Mingdian Yu,Jingqi Lv et al.
Caijun Zhu et al.
The integration of photoacoustic imaging (PAI) and photothermal therapy (PTT) within the second near-infrared (NIR-II) window, offering a combination of high-resolution imaging and precise non-invasive thermal ablation, presents an attracti...
Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach [0.03%]
定制用于RNA疗法靶向递送的脂质纳米颗粒的体内旅程的质量设计方法导航
Elahe Haghighi,Samira Sadat Abolmaali,Ali Dehshahri et al.
Elahe Haghighi et al.
RNA therapeutics, such as mRNA, siRNA, and CRISPR-Cas9, present exciting avenues for treating diverse diseases. However, their potential is commonly hindered by vulnerability to degradation and poor cellular uptake, requiring effective deli...
Metal-phenolic nanoparticles enhance low temperature photothermal therapy for bacterial biofilm in superficial infections [0.03%]
金属酚纳米粒子增强低体温光热疗法治疗浅表感染的细菌生物膜
Yang Ye,Qinqin Zheng,Ziqi Wang et al.
Yang Ye et al.
Bacterial infections, especially induced by multidrug-resistant pathogens, have become a significant global health concern. In the infected tissues, biofilms not only serve as a source of nutrients but also act as protective barriers that i...
Succinate exacerbates mastitis in mice via extracellular vesicles derived from the gut microbiota: a potential new mechanism for mastitis [0.03%]
琥珀酸通过来源于肠道微生物的外泌体加重小鼠乳腺炎：乳腺炎的新机制研究
Min Qiu,Cong Ye,Xiaotong Zhao et al.
Min Qiu et al.
Background: A high grain diet causes an ecological imbalance in the gut microbiota and serves as an important endogenous trigger of mastitis in dairy cows, but the underlying mechanisms are unclear. Our previous study rev...
Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment [0.03%]
一种用于银屑病治疗的新型微针贴片及其制备方法
Jun Li,Zhiguo Yuan,Shuyu Shi et al.
Jun Li et al.
Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (...
Zihan Feng,Yuexin Guo,Yicong Zhang et al.
Zihan Feng et al.
As novel multifunctional materials that merge enzyme-like capabilities with the distinctive traits of nanomaterials, nanozymes have made significant strides in interdisciplinary research areas spanning materials science, bioscience, and bey...
Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization [0.03%]
靶向谷氨酰胺合成酶的AS1411修饰的外泌体-脂质体杂合纳米颗粒抑制脉络膜新生血管形成
Miaomiao Zhang,Xinyue Lu,Lifu Luo et al.
Miaomiao Zhang et al.
Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularizatio...
A novel multifunctional nanocomposite hydrogel orchestrates the macrophage reprogramming-osteogenesis crosstalk to boost bone defect repair [0.03%]
一种新型多功能纳米复合水凝胶可调节巨噬细胞重编-骨发生交叉对话以促进骨缺损修复
Ying Wang,Yedan Chen,Tao Zhou et al.
Ying Wang et al.
Repairing bone defects is a complex cascade reaction process, as immune system regulation, vascular growth, and osteogenic differentiation are essential. Thus, developing a tissue-engineered biomaterial that caters to the complex healing pr...
Inflammation-targeted delivery of Urolithin A mitigates chemical- and immune checkpoint inhibitor-induced colitis [0.03%]
靶向递送备孕期孕妇补充叶酸与子代儿童期哮喘的关系：基于父母的队列研究
Sweta Ghosh,Rajbir Singh,Tanu Jain Goap et al.
Sweta Ghosh et al.
Inflammatory bowel disease (IBD) treatment often involves systemic administration of anti-inflammatory drugs or biologics such as anti-TNF-α antibodies. However, current drug therapies suffer from limited efficacy due to unresponsiveness a...
Reduced graphene oxide loaded with tetrahedral framework nucleic acids for combating orthodontically induced root resorption [0.03%]
四面体框架核酸负载还原氧化石墨烯结合牙齿矫正引起牙根吸收
Wenxiu Yuan,Maotuan Huang,Wenqian Chen et al.
Wenxiu Yuan et al.
Root resorption occurs outside the root or within the root canal. Regardless of its region, root resorption is irreversible and in severe cases, may even cause tooth loss. Clinically, the external surface root resorption is usually a side e...