Remodeling tumor microenvironment using prodrug nMOFs for synergistic cancer therapy [0.03%]
使用前药纳米多孔金属有机框架重构肿瘤微环境以实现协同癌症治疗
Junliang Dong,Jindong Ding,Shifan Luo et al.
Junliang Dong et al.
Metal-organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them to serve as nanocarriers for biopharmaceuticals and nanoreactors for organizing cascad...
Tungsten-based polyoxometalate nanoclusters as ferroptosis inhibitors modulating S100A8/A9-mediated iron metabolism pathway for managing intracerebral haemorrhage [0.03%]
基于钨的聚氧金属簇作为通过调节S100A8/A9介导的铁代谢通路来管理脑出血的铁死亡抑制剂
Yang Yang,Mingzhu Lv,Ruihong Liu et al.
Yang Yang et al.
Background: Intracerebral haemorrhage (ICH) is a devastating neurological disorder with high morbidity and mortality rates, largely owing to the lack of effective therapeutic strategies. Growing evidence has underscored t...
Enzymatically responsive nanocarriers targeting PD-1 and TGF-β pathways reverse immunotherapeutic resistance and elicit robust therapeutic efficacy [0.03%]
酶响应型纳米载体靶向PD-1和TGF-β信号通路逆转免疫治疗抵抗并产生强大的疗效
Ying-Tzu Yen,Zhifan Zhang,Anni Chen et al.
Ying-Tzu Yen et al.
Immune checkpoint inhibitors (ICIs) have revolutionized lung cancer treatment, yet resistance remains a challenge. Co-inhibition of PD-1/PD-L1 and TGF-β shows promise but faces limited efficacy and systemic toxicity. We developed gelatinas...
Modulating metal-organic frameworks by surface engineering of stearic acid modification for follicular drug delivery and enhanced hair growth promotion [0.03%]
通过硬脂酸修饰的表面工程调制金属有机框架用于毛囊药物传递和促进头发生长
Zehui He,Zhenda Liu,Yongtai Zhang et al.
Zehui He et al.
Cyclodextrin metal-organic frameworks (CD-MOF) as delivery carriers have gained great attention in the biomedical field. However, limited by challenges of moisture-sensitive nature, the design and application of CD-MOF-based hair follicle d...
Epitope-focused vaccine immunogens design using tailored horseshoe-shaped scaffold [0.03%]
使用定制的蹄铁形支架设计以表位为重点的疫苗免疫原
Fangxin Zhao,Yue Zhang,Zhiling Zhang et al.
Fangxin Zhao et al.
The continuous emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants highlights the need to update coronavirus 2019 disease (COVID-19) vaccine components. Epitope-based vaccine designs targeting conserved and im...
Surface-engineered bio-manufactured gas vesicles for multimodal imaging of glioma [0.03%]
表面工程生物制造气体囊泡用于胶质瘤的多模式成像
Juanjuan Li,Yutong Cui,Xiaoli Jiang et al.
Juanjuan Li et al.
Integrated imaging techniques offer enhanced medical insights into the central nervous system by combining different modalities. In glioma diagnosis, the challenge often lies in delivering contrast agents effectively across the blood-brain ...
Retraction Note: Structure based innovative approach to analyze aptaprobe-GPC3 complexes in hepatocellular carcinoma [0.03%]
撤稿说明：基于结构的分析肝细胞癌中适配体探针-GPC3复合物的创新方法
Woo-Ri Shin,Dae-Young Park,Ji Hun Kim et al.
Woo-Ri Shin et al.
Intraperitoneal administration of mRNA encoding interleukin-12 for immunotherapy in peritoneal carcinomatosis [0.03%]
腹腔内注射编码白细胞介素-12的mRNA用于腹膜癌病的免疫治疗
Leire Arrizabalaga,Claudia Augusta Di Trani,Myriam Fernández-Sendin et al.
Leire Arrizabalaga et al.
Peritoneal carcinomatosis is an advanced stage of cancer with very limited treatment options. Locoregional immunotherapy is being evaluated as a way to improve efficacy and limit toxicity. This study assessed the efficacy of a cationic poly...
Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways [0.03%]
炎症记忆激活的生物仿生纳米囊通过靶向miR-193a-5p/TLR4/JNK/P38 MAPK通路调节中性粒细胞可塑性和代谢重编程以实现快速糖尿病伤口愈合
Yunlong Fan,Jiaman Yang,Yulin Xie et al.
Yunlong Fan et al.
Diabetic wound therapy faces significant challenges due to the complexity of the wound microenvironment, especially dysregulated immune cell responses and persistent pro-inflammatory sate. Targeting immune cells to reverse pathological woun...
Production of minicell-like structures by Escherichia coli biosynthesizing cadmium fluorescent nanoparticles: a novel response to heavy metal exposure [0.03%]
大肠杆菌生产镉荧光纳米粒样的小型细胞结构：对重金属暴露的一种新型响应
Felipe Valenzuela-Ibaceta,Sergio A Álvarez,José M Pérez-Donoso
Felipe Valenzuela-Ibaceta
The bacterial synthesis of fluorescent semiconductor nanoparticles or quantum dots (QDs), presents a sustainable method for producing nanomaterials with customized optical properties and significant technological potential. However, the und...