Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failure [0.03%]
单细胞多组学分析揭示了一种新型抗氧化聚苯酚纳米粒加载的STAT3激动剂介导心肌细胞铁死亡改善年龄相关性心力衰竭的作用机制
Haoyuan Zheng,Yuan Tian,Dongyu Li et al.
Haoyuan Zheng et al.
Background: Heart failure (HF) is a prevalent and critical cardiac condition that leads to profound structural and functional changes in the heart. Although traditional treatments have shown partial efficacy, the long-ter...
IgM has a better relative distribution in inflammation sites and tumor tissues than IgG [0.03%]
IgM在炎症部位和肿瘤组织中的相对分布优于IgG
Abdulaziz M Aldayel,Mohammad Bosaeed,Sarah Almansour et al.
Abdulaziz M Aldayel et al.
Immunoglobulins (Igs) play a crucial role in host's defense and in developing therapies against inflammatory diseases and cancer. Herein, we first studied the relative distribution of IgM and IgG in mouse models with acute or chronic inflam...
Autologous platelet delivery of siRNAs by autologous plasma protein self-assembled nanoparticles for the treatment of acute kidney injury [0.03%]
自体血浆蛋白自组装纳米颗粒介导的自体血小板siRNA递送，用于急性肾损伤的治疗
Jiafan Wang,Hai Huang,Meng Jia et al.
Jiafan Wang et al.
Acute kidney injury (AKI) involves the activation of intrarenal hemostatic and inflammatory pathways. Platelets rapidly migrate to affected sites of AKI and release extracellular vesicles (EVs) laden with bioactive mediators that regulate i...
Scalable ion concentration polarization dialyzer for peritoneal dialysate regeneration [0.03%]
可扩展的离子浓度极化透析器用于再生腹膜透析液
Wonseok Kim,Seongjun Hong,Kihong Kim et al.
Wonseok Kim et al.
A wearable artificial kidney (WAK) stands poised to offer dialysis treatment with maximal temporal and spatial flexibility for end-stage renal disease (ESRD) patients, while portability has not yet been achieved due to difficulties in porta...
Dual-pathway tumor radiosensitization strategy based on engineered bacteria capable of targeted delivery of AuNPs and specific hypoxia alleviation [0.03%]
基于工程菌实现金纳米颗粒靶向递送和特定组织缺氧缓解的肿瘤放疗增敏方法
Lingling Lei,Haonan Xu,Mingjie Li et al.
Lingling Lei et al.
Background: Radiotherapy efficacy remains constrained by two key challenges: dose-dependent toxicity to healthy tissues at high radiation doses and hypoxia-mediated tumor radioresistance. While radiosensitizers like gold ...
5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia [0.03%]
5-氟尿嘧啶@HFn联合地西他滨诱导焦亡并增强慢性粒细胞白血病的抗肿瘤免疫治疗
Zuowei Yuan,Guoyun Jiang,Ying Yuan et al.
Zuowei Yuan et al.
Background: Tyrosine kinase inhibitors (TKIs) constitute the primary treatment for chronic myeloid leukemia (CML). However, resistance to TKIs often leads to treatment failure. Pyroptosis, a form of programmed cell death,...
Correction: MSC microvesicles loaded G-quadruplex-enhanced circular single-stranded DNA-9 inhibits tumor growth by targeting MDSCs [0.03%]
纠正：负载G-四链体增强的环状单链DNA-9的MSC微囊泡通过作用于MDSCs发挥抑制肿瘤生长的作用
Jingxia Han,Rong Qin,Shaoting Zheng et al.
Jingxia Han et al.
Published Erratum
Journal of nanobiotechnology. 2025 Mar 26;23(1):250. DOI:10.1186/s12951-025-03313-1 2025
Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol [0.03%]
通过脂质体传递7-脱氢胆固醇辐射诱导的铁死亡
Jianwen Li,Shuyue Zhan,Wei Yang et al.
Jianwen Li et al.
Background: Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge. ...
Extracellular vesicles: a new frontier in diagnosing and treating graft-versus-host disease after allogeneic hematopoietic cell transplantation [0.03%]
胞外囊泡：同种异体造血细胞移植后诊断和治疗移植物抗宿主病的新领域
Peipei Wu,Zhangfei Wang,Yongping Sun et al.
Peipei Wu et al.
Graft-versus-host disease (GvHD) is a prevalent complication following allogeneic hematopoietic stem cell transplantation (HSCT) and is characterized by relatively high morbidity and mortality rates. GvHD can result in extensive systemic da...
Correction: Near-infrared light triggered in situ release of CO for enhanced therapy of glioblastoma [0.03%]
修正：近红外光触发原位释放一氧化碳增强胶质母细胞瘤治疗效果
Juan Ge,Miaomiao Zuo,Qirong Wang et al.
Juan Ge et al.
Published Erratum
Journal of nanobiotechnology. 2025 Mar 25;23(1):245. DOI:10.1186/s12951-025-03162-y 2025