Combination therapy with lipid prodrug liposomes reshapes disease-associated neutrophils to promote the cancer-immunity cycle [0.03%]
含有类脂前药的脂质体组合疗法重塑与疾病相关中性粒细胞以促进癌症免疫循环
Dezhi Sui,Yanzhi Song,Yihui Deng
Dezhi Sui
Neutrophils play a critical role in the cancer-immunity cycle and are associated with poor clinical outcomes. Recent research has primarily focused on the targeted delivery, phenotypic reversal, and reprogramming of tumor-associated neutrop...
Targeting GDF15 to enhance immunotherapy efficacy in glioblastoma through tumor microenvironment-responsive CRISPR-Cas9 nanoparticles [0.03%]
通过肿瘤微环境响应性CRISPR-Cas9纳米颗粒靶向GDF15以提高胶质母细胞瘤免疫疗法的疗效
Cheng Zou,Xiao Liu,Weizhong Wang et al.
Cheng Zou et al.
Despite the outstanding clinical success of immunotherapy, its therapeutic efficacy in glioblastoma (GBM) is still limited. To identify critical regulators of GBM immunity, we constructed a mouse single-guide RNA (sgRNA) library correspondi...
Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy [0.03%]
针对somatostatin受体的聚合物纳米平台实现高效的CRISPR / Cas9基因编辑以增强肝细胞癌的协同治疗
Suqin Zhang,Meng Li,Jingyi Zeng et al.
Suqin Zhang et al.
The CRISPR/Cas9 system-based gene therapy can fundamentally address the issues of cancer occurrence, development, progression, and metastasis. However, the lack of targeting and effectiveness hinders gene therapy from entering clinical appl...
Metal-organic framework nanoparticles activate cGAS-STING pathway to improve radiotherapy sensitivity [0.03%]
金属有机框架纳米颗粒通过激活cGAS-STING通路提高放疗敏感性
Xinyao Hu,Hua Zhu,Yang Shen et al.
Xinyao Hu et al.
Tumor immunotherapy aims to harness the immune system to identify and eliminate cancer cells. However, its full potential is hindered by the immunosuppressive nature of tumors. Radiotherapy remains a key treatment modality for local tumor c...
Injectable platelet-mimicking silk protein-peptide conjugate microspheres for hemostasis modulation and targeted treatment of internal bleeding [0.03%]
用于止血调节和内部出血靶向治疗的可注射仿血小板丝蛋白-肽接枝微球
Yajun Shuai,Yu Qian,Meidan Zheng et al.
Yajun Shuai et al.
Uncontrolled deep bleeding, commonly encountered in surgical procedures, combat injuries, and trauma, poses a significant threat to patient survival and recovery. The development of effective hemostatic agents capable of precisely targeting...
Correction: Neutrophil-macrophage hybrid membrane-coated prussian blue nanozyme for ulcerative colitis treatment and mechanistic insights [0.03%]
校正：中性粒细胞-巨噬细胞杂合膜包裹的普鲁士蓝纳米酶在溃疡性结肠炎治疗中的应用及机制探索
Chunli Hu,Yanhui Wang,Shengtao Liao et al.
Chunli Hu et al.
Published Erratum
Journal of nanobiotechnology. 2025 Feb 20;23(1):125. DOI:10.1186/s12951-025-03207-2 2025
New horizons for the therapeutic application of nanozymes in cancer treatment [0.03%]
纳米酶在癌症治疗中治疗应用的新视野
Pravanjan Malla,Yu-Ming Wang,Chia-Hao Su
Pravanjan Malla
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations of conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilit...
Extracellular vesicle-mediated gene therapy targets BRAFV600E-mutant colorectal cancer by inhibiting the MEK1/2-ERK1/2 pathway [0.03%]
通过抑制MEK1/2-ERK1/2通路，胞外囊泡介导的基因治疗靶向BRAFV600E突变结肠癌
Di Wang,Liwei Wang,Wei Zhang et al.
Di Wang et al.
Background: Patients with colorectal cancer (CRC) harboring BRAF mutation have a poor prognosis. The median survival time for patients with advanced BRAFV600E-mutant CRC is only approximately one year. Owing to the insens...
Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells [0.03%]
生物纳米复合物干扰铁稳态诱导癌细胞发生非典型性铁死亡
Xin Wang,Tianyi Zhang,Shuai Wang et al.
Xin Wang et al.
The targeted elevation of the labile iron pool (LIP) represents the most direct and effective strategy to induce ferroptosis in cancer cells. However, the efficiency of increasing LIP to induce ferroptosis via iron supplementation is contro...
A wearable enzyme sensor enabled by the floating-gate OECT with poly(benzimidazobenzophenanthroline) as the catalytic layer [0.03%]
采用聚(苯并咪唑苯并菲仁)作为催化层的浮栅OECT使能的可穿戴酶传感器
Jianlong Ji,Jing Xiao,Fan Zhang et al.
Jianlong Ji et al.
With the advantages of miniaturization, simple device structure, and fast response, the organic electrochemical transistor (OECT) has become an emerging platform for developing wearable enzyme sensors for real-time health monitoring. The fl...